The Nature and Function of the Alpha Cells of the Pancreas: Their Possible Role in the Production of Glucagon

Korp, W; LeCompte, Philip M.

doi:10.2337/diab.4.5.347

Cited by 26 publications

(2 citation statements)

References 33 publications

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“…The way in which the Islets are Formned.-Previous work on the development of the pancreatic islets has been summarized by Burkl [1951] and by Korp and Lecompte [1955].…”

mentioning

confidence: 99%

The Development of the Islets of Langerhans in the Human Fœtus

Robb

1961

Exp Physiol

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A hiistological study was made of the pancreatic islets of thirty-seven lhuman fcetuses, with weights ranging from 28 to 3600 g. (10 weeks' gestation to full term), using Gomori's methods of differential staining for the alpha and beta cells. Five stages of development of the islets were observed. These are described and illustrated by photomicrographs. The way in which these results supplement or differ from those of previous workers is discussed, and some experimental work concerning the influence of anterior pituitary hormones on the development of the pancreatic islets in other species is briefly reviewed.

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“…The way in which the Islets are Formned.-Previous work on the development of the pancreatic islets has been summarized by Burkl [1951] and by Korp and Lecompte [1955].…”

mentioning

confidence: 99%

The Development of the Islets of Langerhans in the Human Fœtus

Robb

1961

Exp Physiol

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“…Bensley (1938) later reported the alpha granules to be water-soluble and the beta granules to be re moved by 70% alcohol. In most species the beta cells are the greatest in number and tend to be concentrated toward the cen ter of the islet, while the alpha cells assume a more peripheral location, although there are exceptions (Thomas, 1937;Korp and LeCompte, 1955;Bjorkman et a2., 1963). In the dog the ratio of beta to alpha to other cell types is 75%, 20%, and 5%, respectively (Hunt, 1936).…”

Section: General Histologymentioning

confidence: 99%

Age changes in the canine pancreas: histomorphological, electron microscopic, and biochemical study

Saladino¹,

Charles²

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Studies in the Relationship of Amino Acids to Infantile Hypoglycemia

Cochrane¹

1960

Arch Pediatr Adolesc Med

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Spontaneous hypoglycemia is not a disease but an indication of a defect in the metabolism of glucose in the organism. Excellent reviews by Skillern,1 Conn,2 and McQuarrie3,4 have indicated the large number of possible etiologic factors. Several authors have emphasized that hypoglycemia occurring in infants and children is not an uncommon condition. In McQuarrie's 3 report, 26 of 43 cases of hypoglycemia of infancy were classified as idiopathic and the author referred to these as "idiopathic infantile hypoglycemosis."In 1956, Cochrane et al.5 observed that certain hypoglycemic infants treated with a high-protein diet had an increased frequency of hypoglycemic attacks. This clinical observation that protein aggravates some cases of infantile hypoglycemia was supported by the finding of a marked fall in blood sugar in three cases after the administration of the amino acid L-leucine.5 The selection of this particular amino acid was partly fortuitous circumstance and partly the observation from reports in the literature that glucose administration to normal men results in a fall in blood amino acid, leucine being depressed more than other amino acids.6,7 Leucine was administered to observe if a reciprocal rela¬ tionship existed, i.e., feeding leucine would lower blood glucose. Two of the cases were siblings whose father gave a history of convulsions as an infant. There was no apparent cause for their hypoglycemia. The third infant was found to have an elevated plasma level of insulin-like activity and histological evidence of /?-cell hyperplasia of the pancreas after laparotomy. The oral administration of the amino acid L-leucine and of isovaleric acid produced a profound lowering of the blood glucose in all three in¬ fants and the father of the two siblings. No similar fall in blood sugar occurred when normal infants and adults were tested with L-leucine. Further studies of the role of amino acids in the hypoglycemia of infants have now been carried out. The experimental work and results, divided into three parts, are here presented. Part I describes observations made in 12 hypoglycémie infants and children after the oral administration of various amino acids. Part II describes the results of in vivo investigations in normal rabbits, rats, and dogs after the intravenous administration of L-leucine. Part III outlines the results of in vitro experiments of the effect of various amino acids on glucose uptake by isolated rat dia¬ phragm. A review of the literature relative to the topic is given, with a discussion of possible explanations for the hypoglycémie effect of L-leucine.A description of the treatment prescribed in the hypoglycémie infants is given to illus¬ trate the practical application of the investi¬ gative findings.Part I: Hypoglycémie Infants Six patients ranging in age from \% to 8"/> years and previously diagnosed as idiopathic hypo-

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The Nature and Function of the Alpha Cells of the Pancreas: Their Possible Role in the Production of Glucagon

Cited by 26 publications

References 33 publications

The Development of the Islets of Langerhans in the Human Fœtus

The Development of the Islets of Langerhans in the Human Fœtus

Age changes in the canine pancreas: histomorphological, electron microscopic, and biochemical study

Studies in the Relationship of Amino Acids to Infantile Hypoglycemia

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