The field of human factors engineering (HFE), also known as ergonomics, is concerned with understanding the capabilities and characteristics of humans and applying this knowledge to improve the tools, machines, and systems with which humans interact. 1 HFE seeks to improve human performance and safety by focusing on the cognitive and physical capabilities of the "user" as they operate in their work environment, and using this information to inform system design. Knowledge of cognitive capabilities includes understanding attention processes, memory demands, perception, information processing, and decision-making. Physical capabilities include understanding the anatomy, physiology, and biomechanics of the user. Given the focus on both cognitive and physical capabilities, HFE is a multidisciplinary field that draws from psychology, engineering, and anthropometry.This chapter reviews common methods used in HFE and the application of HFE to health care with a focus on emergency medicine. Specific topics covered include workflow, overcrowding, teamwork, health information technology, task interruptions, and clinical decision-making. While HFE has an extensive history in domains such as aviation and nuclear energy, the application of HFE in health care is still in its early stages.