The Nature and Problem of Dental Caries in Man

Silverstone, Leon M.; Johnson, N. W.; Hardie, J. M.; Williams, Ruth

doi:10.1007/978-1-349-16547-6_1

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Although chemical acid dissolves the mineral phase of dentine, it does not have a major effect on the matrix because the surface is protected by apatite crystallites. During biofilm challenge, proteolytic enzymes that are liberated by oral bacteria then destroy the organic matrix so that apatite crystals became detached and dentine’s structure collapses 31,32 . In this way, cariogenic biofilm challenge would weaken dentine and generate caries‐like lesions.…”

Section: Discussionmentioning

confidence: 99%

Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms

Chu

Mei

Seneviratne

2011

Int J Paed Dentistry

183

145

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BACKGROUND. Silver diamine fluoride (SDF) has been shown to be a successful treatment for arresting caries. However, the mechanism of SDF is to be elucidated. AIM. To characterize the effects of SDF on dentine carious induced by Streptococcus mutans and Actinomyces naeslundii. DESIGN. Thirty-two artificially demineralized human dentine blocks were inoculated: 16 with S. mutans and 16 with A. naeslundii. Either SDF or water was applied to eight blocks in each group. Biofilm morphology, microbial kinetics and viability were evaluated by scanning electron microscopy, colony forming units, and confocal microscopy. The crosssection of the dentine carious lesions were assessed by microhardness testing, scanning electron microscopy with energy-dispersive x-ray spectroscopy and Fourier transform infrared spectroscopy. RESULTS. Biofilm counts were reduced in SDF group than control (P < 0.01). Surfaces of carious lesions were harder after SDF application than after water application (P < 0.05), in S. mutans group, Ca and P weight percentage after SDF application than after water application (P < 0.05). Lesions showed a significantly reduced level of matrix to phosphate after SDF treatment (P < 0.05). CONCLUSION. Present study showed that SDF posses an anti-microbial activity against cariogenic biofilm of S. mutans or A. naeslundii formed on dentine surfaces. SDF slowed down demineralization of dentine. This dual activity could be the reason behind clinical success of SDF.

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Section: Discussionmentioning

confidence: 99%

Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms

Chu

Mei

Seneviratne

2011

Int J Paed Dentistry

183

145

View full text Add to dashboard Cite

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“…Demineralination and erosion of enamel by organic acid are major factors in caries development (6). Plaque bacteria produce organic acid as a product of carbohydrate metabolism (7).…”

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confidence: 99%

“…Plaque bacteria produce organic acid as a product of carbohydrate metabolism (7). In contrast, nitrogenous substances are metabolized by plaque to form ammonia which has an alkalinizing effect on plaque (7,8 6.67). The contribution of salivary pH to variability in plaque pH is 20-fold less than that of SalUN.…”

mentioning

confidence: 99%

Caries Resistance in Children with Chronic Renal Failure: Plaque pH, Salivary pH, and Salivary Composition

1985

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ABSTRACT. W e studied properties of saliva and of dental plaque which affect the caries process in an effort to understand the low prevalence of caries in patients with chronic renal failure. Plaque pH, before and following carbohydrate exposure, saliva pEI, and saliva composition were evaluated in children and adolescents with chronic renal failure (n = 10) and successful renal transplantation (n = 1 I), and in two comparison groups of healthy children with few caries (n = 15) and numerous caries (n = 15).Salivary urea nitrogen concentration was elevated in all subjects with elevated serum urea nitrogen concentration. Chronic renal failure subjects had significantly higher salivary urea nitrogen concentration than transplanted subjects. Plaque p H correlated directly with salivary urea nitrogen concentration and was significantly more alkaline in chronic renal failure than transplant or comparison groups. Salivary urea nitrogen concentration accounted for the majority of variability in plaque pH, salivary p H and salivary phosphorous contributed negligibly. Absolute p H drop following carbohydrate exposure did not differ among groups, but because baseline plaque p H was elevated for chronic renal failure subjects, minimum p H did not attain Received February 5, 1985; accepted March 13,1985. cariogenic levels. Our data support the hypothesis that the relative paucity of caries in patients with chronic renal failure results from alteration of plaque by metabolic end products of urea metabolism. Our data further suggest that transplanted patients whose renal function is normal may be a t increased risk of caries, especially if enamel hypoplasia is present and oral hygiene is poor. (Pediatr Res 19: 796-799,1985)Abbreviations CRF, chronic renal failure SalUN, salivary urea nitrogen concentration Children with CRF have relatively few dental caries (1, 2) despite common occurrence of conditions which should increase risk of caries. Poor oral hygiene (3,4) and enamel hypoplasia (1, 2) are prevalent in CRF, and dietary supplementation of calories (5) results in cariogenic diets for many CRF patients. In an effort to explain low caries prevalence we designed a study to evaluate properties of plaque and saliva which might affect the caries process.Demineralination and erosion of enamel by organic acid are major factors in caries development (6). Plaque bacteria produce organic acid as a product of carbohydrate metabolism (7). In

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The Nature and Problem of Dental Caries in Man

Cited by 2 publications

References 17 publications

Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms

Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms

Caries Resistance in Children with Chronic Renal Failure: Plaque pH, Salivary pH, and Salivary Composition

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