The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function

Curtis, Vivienne; Thompson, Jessica; Seal, Marc L.; Monks, P J; Lloyd, Adrian J.; Harrison, Louise; Brammer, Michael; Williams, Steven; Murray, Robin M.; Young, Allan H.; Ferrier, I. Nicol

doi:10.1111/j.1399-5618.2007.00422.x

Cited by 35 publications

(30 citation statements)

References 63 publications

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“…We could not verify a similar effect in our present sample, but we note that the region previously reported was centered in left dorsolateral prefrontal cortex and extended only marginally to the most apical part of Broca's area. Importantly for the specificity of our findings, neither that report [Curtis et al, 2007] nor an earlier one by our group [Curtis et al, 2001] found significant differences between bipolar subjects and controls in right inferior frontal areas. Current evidence, however, increasingly supports an overlap in genetic risk factors between schizophrenia and bipolar disorder [Cardno et al, 2002;Owen et al, 2007].…”

Section: Discussioncontrasting

confidence: 65%

“…Because of a relative scarcity of functional neuroimaging studies in bipolar disorder, it is more difficult to place our results in context. However, using a similar overt letter fluency task in a sample of 12 bipolar subjects, Curtis et al [2007] found increased activation in left frontal areas for bipolar subjects relative to healthy controls. We could not verify a similar effect in our present sample, but we note that the region previously reported was centered in left dorsolateral prefrontal cortex and extended only marginally to the most apical part of Broca's area.…”

Section: Discussionmentioning

confidence: 94%

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Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

Costafreda¹,

Fu²,

Picchioni³

et al. 2009

Human Brain Mapping

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During verbal-fluency tasks, impairments in performance and functional abnormalities in the inferior frontal cortex have been observed in both schizophrenia patients and their unaffected relatives. We sought to examine whether such functional abnormalities are a specific marker of genetic vulnerability to schizophrenia. We studied a sample of 132 subjects, comprising 39 patients with schizophrenia, 10 unaffected monozygotic (MZ) cotwins of schizophrenia probands, 28 patients with bipolar disorder, 7 unaffected MZ cotwins of bipolar disorder probands and 48 healthy controls. Blood oxygen level-dependent response was measured using functional magnetic resonance imaging during the performance of an overt verbal-fluency task with two levels of task difficulty, in a cytoarchitectonic region of interest encompassing Brodmann areas 44 and 45 bilaterally. Patients with schizophrenia and the unaffected MZ cotwins of schizophrenia probands showed increased activation in the inferior frontal cortex relative to healthy controls and bipolar patients. Increased engagement of the inferior frontal cortex during verbal-fluency may thus be a marker of genetic vulnerability to schizophrenia.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 94%

Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

Costafreda¹,

Fu²,

Picchioni³

et al. 2009

Human Brain Mapping

View full text Add to dashboard Cite

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“…This has led to neurobiological theories that attribute cognitive deficits and emotional changes to a disconnect between cognitive top-down centers in the ventrolateral and dorsolateral PFC with emotional bottom-up centers in medial and orbitofrontal PFC and limbic regions (23, 24). Supporting these theories, fMRI studies of WM in inter-episode patients with BD have primarily found attenuated activation patterns in dorsolateral and ventrolateral PFC compared to healthy participants (21), though this is not always the case (25, 26). Additionally, studies demonstrate decreased activation in other brain regions underlying WM including the supramarginal gyrus (5).…”

mentioning

confidence: 98%

Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder

et al. 2013

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Objectives Individuals with bipolar disorder (BD) have trait-like deficits in attention and working memory (WM). A fundamental dissociation for most verbal WM theories involves the separation of sensory-perceptual encoding, reliant upon attention, from the maintenance of this information in WM proper. The present paper examined if patients with BD demonstrate differential neural changes in encoding and maintenance WM processes that underlie cognitive impairment. Methods Event-related functional magnetic resonance imaging during a delayed match-to-sample WM paradigm was employed with 23 inter-episode medicated patients with BD and 23 demographically similar healthy comparison participants. We examined brain regions during encoding and maintenance task intervals to identify regions that demonstrated differential effects between groups. Medication effects and functional connectivity between prefrontal cortex and basal ganglia/thalamus were examined during the encoding interval due to the importance of these regions and the connection among them for encoding into WM. Results Patients with BD exhibited deficits in task accuracy and attenuated brain response during the encoding interval in areas of the prefrontal cortex, caudate, thalamus, and posterior visual regions. In contrast, patients with BD exhibited hyperactivation in posterior sensory regions during the maintenance interval. Among the BD group, those with greater medication load exhibited the greatest brain response within the prefrontal cortex. Conclusions Reduction in activation during the encoding interval suggests that attentional deficits underlie WM deficits in patients with BD. These deficits appear to be trait-like in so far as they were observed during periods of euthymia in patients with BD. Medication effects remain to be further explored as there was evidence of prefrontal changes dependent on medication load.

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“…N = number in sample. BD = Euthymic bipolar patients; CON = Healthy comparison subjects; PFC = prefrontal cortex; ↑ = increase brain response in euthymic bipolar patients relative to healthy comparison subjects; ↓ = decrease brain response in euthymic bipolar patients relative to healthy comparison subjects; --- = no performance change or prefrontal region identified. Citations: Adler, Holland, Schmithorst, Tuchfarber, & Strakowski, 2004; Allin et al, 2010; Costafreda et al, 2009; Curtis et al, 2001; Curtis et al, 2007; Drapier et al, 2008; Frangou, Kington, Raymont, & Shergill, 2007; Glahn et al, 2010; Gruber, Rogowska, & Yurgelun-Todd, 2004; Hamilton et al, 2009; Hassel et al, 2008; Jogia, Dima, Kumari, & Frangou, 2011; Kaladjian et al, 2009; Kronhaus et al, 2006; Lagopoulos, Ivanovski, & Malhi, 2007; Lagopoulos & Malhi, 2007; Malhi, Lagopoulos, Owen et al, 2007; Malhi, Lagopoulos, Sachdev et al, 2007; Malhi et al, 2005; Monks et al, 2004; Pompei, Dima, Rubia, Kumari, & Frangou, 2011; Pompei, Jogia et al, 2011; Robinson et al, 2009; Robinson et al, 2008; Strakowski et al, 2005; Surguladze et al, 2010; Thermenos et al, 2010; Wessa et al, 2007; Yurgelun-Todd et al, 2000. …”

Section: Figurementioning

confidence: 99%

Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: A review of functional neuroimaging studies

McKenna

Eyler

2012

Clinical Psychology Review

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Prefrontal cortex (PFC) mediated cognitive and emotional processing deficits in bipolar disorder lead to functional limitations even during periods of mood stability. Alterations of sleep and circadian functioning are well-documented in bipolar disorder, but there is little research directly examining the mechanistic role of sleep and/or circadian rhythms in the observed cognitive and emotional processing deficits. We systematically review the cognitive and emotional processing deficits reliant upon PFC functioning of euthymic patients with bipolar disorder and in healthy individuals deprived of sleep. The evidence from two parallel lines of investigation suggests that sleep and circadian rhythms may be involved in the cognitive and emotional processing deficits seen in bipolar disorder through overlapping neurobiological systems. We discuss current models of bipolar highlighting the PFC-limbic connections and discuss inclusion of sleep-related mechanisms. Sleep and circadian dysfunction is a core feature of bipolar disorder and models of neurobiological abnormalities should incorporate chronobiological measures. Further research into the role of sleep and circadian rhythms in cognition and emotional processing in bipolar disorder is warranted.

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The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function

Abstract: We have demonstrated abnormal prefrontal activation in bipolar patients across a range of language tasks with varying task demands.

Cited by 35 publications

References 63 publications

Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder

Overlapping prefrontal systems involved in cognitive and emotional processing in euthymic bipolar disorder and following sleep deprivation: A review of functional neuroimaging studies

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