The nature of allorosette-forming cells in rats

Abstract

ARFC appear in the spleen after transplantation of organs or tissues and immunization with nucleated cells between isohistogenic rat strains. The allorosette formation of rat spleen cells and T cells, isolated by an Ig-anti-Ig column, was examined. It has been demonstrated that 90% of ARFC are B cells and 10% are T cells. The allorosette phenomenon can therefore be considered an immune reaction concerning predominantly the B-cell system. Allorosette-forming T cells are discussed to be SD-antigen-recognizing cytotoxic T cells.