The nature of measles virus

The ultrastructure of canine distemper virus

“…The inner component of distemper virus particles seems to be a helical structure of the same appearance and size as that found in large myxoviruses (16) as well as in measles and rinderpest virus (3,4). The diameter of this type of helix (180 ~) is distinct from that present in members of the influenza virus subgroup (90 ~).…”

“…b) The particles exhibit characteristic features similar to those of the immunologieally related measles and rinderpest virus (3,4) and thus also to members of the group of large myxoviruses (10--13). c) After equilibrium eentrifugation in CsC1 gradients there is a positive correlation between infectivity of fractions and their content of relatively intact particles as found in the electron microscope (Norrby, to be published).…”

“…More recently the ultrastructure of the two latter viruses has been revealed (3,4) and tin:ned out to be similar to that of the members of the group of large myxoviruses. In those analyses the extremely useful negative staining technique of Brenner and Home (5) was used.…”

Studies on Hemagglutination by NDV.

“…Flux rate od cholesterol from plasma to aorta was calculated by the method of Newman and Zilversrnit( 7 ) as previously described (8). Plasma lipoproteins were separated in the ultracentrifuge (9). The adventitia was stripped from the aorta.…”

Influence of Actinomycin D, Aurantine and 5-Bromdeoxyuridine on Production of Nucleic Acid and Protein in Measles Virus

“…However, according to electron microscopic studies, the structure of measles virus has been shown to be similar to that of the RNA-containing myxoviruses ( 14) and, furthermore, inhibitors of DNA synthesis do not prevent reproduction of measles virus ( 10,12) nor of other RNA-containing viruses. Inhibition by S-fluordeoxyuridine and by actinomycin D of the RNA-containing Rous sarcoma virus is explained by the influence of the viral RNA The purpose of the present study was to investigate some aspects of measles virus synthesis.…”