The Nature of Proteins

Ekambaram, Rajasekaran; Vinobha, C. S.; Vijayasarathy, Marimuthu; Senthil, Renganathan; Sankarganesh, P.

doi:10.1109/iacsit-sc.2009.46

Cited by 10 publications

(10 citation statements)

References 3 publications

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“…The carbon distribution along the sequence was analysed using CARBANA program available online [3]. A outer length of 700 atoms are chosen here to have broader view on carbon distribution.…”

Section: Methodsmentioning

confidence: 99%

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Study on Carbon Distribution at Protein Regions of Disorder

Akila¹,

Sneha²,

Ekambaram³

2012

IJBBB

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Abstract-Hydrophobic interaction is the dominant force in proteins that arises due to carbon. The content and distribution of this carbon make a protein to fold in some form to have a specific function. Diseased proteins are expectedly differing from this carbon distribution pattern. This is taken as focus of this work by taking neurodegenerative protein, the SOD for study. The carbon distribution analysis program is able to identify the disordered region clearly. A long stretch of hydrophilic/hydrophobic regions with different combination of amino acid is considered as disordered regions. This disorder is due to unfolding or misfolding. The program developd for this purpose can further analysis the proteins for identification of mutational sites for stabilisation.

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Section: Methodsmentioning

confidence: 99%

“…Recently it is reported that globular proteins prefer to have 31.45% of carbon for its stability and can be used as standard for carbon distribution analysis [3].…”

Section: Introductionmentioning

confidence: 99%

Study on Carbon Distribution at Protein Regions of Disorder

Akila¹,

Sneha²,

Ekambaram³

2012

IJBBB

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“…Proteins evolve based on carbon content and may influence the code in genes. It is reported that proteins prefers to have 31.45% of carbon for its stability [2], [3]. Depending upon the carbon content, the protein and the corresponding mRNA survive and passed to next generation.…”

Section: Resultsmentioning

confidence: 99%

Adenine in Viral mRNAs Manipulate the Carbon in Proteins

Ekambaram¹,

Akila²

2011

IJBBB

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Proteins function is determined by the nature of carbon along its sequence. This carbon along the protein is determined by the nucleotides in the gene. The adenine in viral genetic material and carbon distribution along its proteins are the focus of this study. The results reveal that the presence of higher adenine content in viral material add adequate number of large number of hydrophobic residues in its proteins. The natural way of adding different sequences during development and evolution is better understood based on this carbon distribution analysis. Appropriate mutation that changes in carbon content and distribution in viral proteins might improve the functionality of the protein.

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“…Our idea of conversion of arrangement of carbon profile may be of useful from nearing the untold answer to the human sufferings. Our idea was to go back a decade of carbon analysis finding maintenance of carbon value within the system of biologically important protein molecule which was analyzed after careful observation that protein attempting to maintain fraction of carbon 0.3144 at all level [1]. Arrangements are in such a way that aminoacid composition arranged according to the need based of carbon profile of law of rule.…”

Section: Introductionmentioning

confidence: 99%

Existence of Nano Level Force in Protein Plays Applications of Maximum Untold Understanding of Life Form

Ekambaram,

Meenal,

Indupriya

2019

IJEAT

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There are many interactive forces between atoms applied to solve the problem of nature of molecules. One would go on applying this to several diseases and sufferings. On doing so, we have discovered that a new dimension of atomic arrangements playing a role in existence of force of interaction at nano level say at 1.6 nm. Arrangements are in such way that it maintains a carbon fraction of 0.3144 in the structure of biologically important molecule called protein. Arrangements are important from maintaining structure and another way of interaction due to the deficiency of this domain formation. All our analysis conclude that there is new kind of force of attraction available for advancing the science here in biology and other field as well as other elements possess this nano level forces of attraction. Our results are validated with crystal availability because of force existence. Otherwise other may have to be studied accordingly. Bond of all atoms involved in domain formation are altered from original value of bond formation but increased or decreased according to the type of bonds. Alteration can be a measure of this newly identified nano level force of interaction. Our analysis can be extended to other problems in our science of untold answer

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The Nature of Proteins

Cited by 10 publications

References 3 publications

Study on Carbon Distribution at Protein Regions of Disorder

Study on Carbon Distribution at Protein Regions of Disorder

Adenine in Viral mRNAs Manipulate the Carbon in Proteins

Existence of Nano Level Force in Protein Plays Applications of Maximum Untold Understanding of Life Form

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