1976
DOI: 10.1042/bj1550637
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The nature of the 5'-linked 5' nucleotide sequence at the 5' end of rabbit globin messenger ribonucleic acid

Abstract: Poly(A)-containing messenger RNA isolated from rabbit reticulocytes as estimated by periodate oxidation and condensation with [3H]isoniazid has two oxidizable end groups per molecule of mol. wt. 220000. When the mRNA is subjected to stepwise degradation by beta-elimination, only one oxidizable end-group is found. This indicates that one of the 2',3' hydroxyl end-groups is linked through the normal 3'--5' phosphodiester bond, but that the other is linked in such a way that after stepwise degradation no new 2',3… Show more

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Cited by 13 publications
(1 citation statement)
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“…In addition, formulation of a culture medium specially designed to favor high incorporation of a given precursor may introduce serious deviations from normalcy in the nature and types of mRNAs synthesized. For example, attempts to increase the specific activity of methionine in culture medium by decreasing the total concentration of this amino acid has been shown to result in mRNAs with undermethylated caps (Hunt and Oakes, 1976).…”
mentioning
confidence: 99%
“…In addition, formulation of a culture medium specially designed to favor high incorporation of a given precursor may introduce serious deviations from normalcy in the nature and types of mRNAs synthesized. For example, attempts to increase the specific activity of methionine in culture medium by decreasing the total concentration of this amino acid has been shown to result in mRNAs with undermethylated caps (Hunt and Oakes, 1976).…”
mentioning
confidence: 99%