The Nature of the Association Between Childhood ADHD and the Development of Bipolar Disorder: A Review of Prospective High-Risk Studies

Duffy, Anne

doi:10.1176/appi.ajp.2012.11111725

Cited by 90 publications

(83 citation statements)

References 52 publications

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“…66 However, in the offspring of lithium nonresponders, attention deficit, learning disabilities, and cluster A traits were also frequent childhood risk antecedents. 77 Findings regarding the evolution of psychopathology from this Canadian longitudinal high-risk study have been replicated in other independent longitudinal high-risk studies. 41,60,71 These collective observations were recently distilled into a clinical staging model that was tested using multi-state models.…”

Section: Clinical Staging: Prospective High-risk Studiessupporting

confidence: 58%

Toward a Comprehensive Clinical Staging Model for Bipolar Disorder: Integrating the Evidence

Duffy

2014

Can J Psychiatry

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Objectives: To describe key findings relating to the natural history and heterogeneity of bipolar disorder (BD) relevant to the development of a unitary clinical staging model. Currently proposed staging models are briefly discussed, highlighting complementary findings, and a comprehensive staging model of BD is proposed integrating the relevant evidence.Method: A selective review of key published findings addressing the natural history, heterogeneity, and clinical staging models of BD are discussed. Results:The concept of BD has broadened, resulting in an increased spectrum of disorders subsumed under this diagnostic category. Different staging models for BD have been proposed based on the early psychosis literature, studies of patients with established BD, and prospective studies of the offspring of parents with BD. The overarching finding is that there are identifiable sequential clinical phases in the development of BD that differ in important ways between classical episodic and psychotic spectrum subtypes. In addition, in the context of familial risk, early risk syndromes add important predictive value and inform the staging model for BD. Conclusions:A comprehensive clinical staging model of BD can be derived from the available evidence and should consider the natural history of BD and the heterogeneity of subtypes. This model will advance both early intervention efforts and neurobiological research. W W WVers un modèle complet de staification clinique du trouble bipolaire : intégrant l'évidence Objectifs : Décrire les principaux résultats concernant l'histoire naturelle et l'hétérogénéité du trouble bipolaire (TB) qui se rapportent à l'élaboration d'un modèle unitaire de stades cliniques. Les modèles de staification présentement proposés sont brièvement présentés, de même que les résultats complémentaires, et un modèle complet de staification du TB est proposé qui intègre les données probantes pertinentes.Méthode : Est présentée une revue sélective des principaux résultats publiés sur l'histoire naturelle, l'hétérogénéité, et les modèles de staification clinique du TB.Résultats : Le concept du TB s'est élargi, ce qui a donné un spectre accru de troubles classés dans cette catégorie diagnostique. Différents modèles de staification du TB ont été proposés d'après la littérature sur la psychose précoce, les études de patients souffrant d'un TB établi, et les études prospectives des enfants de parents souffrant de TB. Le résultat déterminant est qu'il y a des phases cliniques séquentielles identifiables dans le développement du TB qui diffèrent de manière importante entre les sous-types épisodiques classiques et ceux du spectre psychotique. En outre, dans le contexte du risque familial, les syndromes de risque précoce ajoutent une valeur prédictive importante et éclairent le modèle de stadification du TB.Conclusions : Un modèle complet de stadification clinique du TB peut être déduit des données probantes disponibles et devrait tenir compte de l'histoire naturelle du TB et de l'hétérogénéité des sous-types. Ce ...

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Section: Clinical Staging: Prospective High-risk Studiessupporting

confidence: 58%

Toward a Comprehensive Clinical Staging Model for Bipolar Disorder: Integrating the Evidence

Duffy

2014

Can J Psychiatry

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“…In more recent reports, the rates of comorbid ADHD in samples of bipolar children [21••] and bipolar high-risk cohorts are not elevated, except in offspring of adults with BD that were lithium non-responders [35].…”

Section: Epidemiologymentioning

confidence: 99%

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

Marangoni¹,

Chiara²,

Faedda

2015

Curr Psychiatry Rep

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Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) are neurodevelopmental disorders with onset in childhood and early adolescence, and common persistence in adulthood. Both disorders are often undiagnosed, misdiagnosed, and sometimes over diagnosed, leading to high rates of morbidity and disability. The differentiation of these conditions is based on their clinical features, comorbidity, psychiatric family history course of illness, and response to treatment. We review recent relevant findings and highlight epidemiological, clinical, family history, course, and treatment-response differences that can aid the differential diagnosis of these conditions in an outpatient pediatric setting.

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“…However, in general population cohorts the relationship between subthreshold symptoms and clinical outcomes has modest contemporaneous specificity and predictive value. This is because childhood subthreshold manic symptoms in the general population are common (5-25%) (Shankman et al, 2009;Tijssen et al, 2010a), they are present in children with a variety of disruptive disorders and are associated with multiple adult diagnoses, most commonly BD, anxiety, depression and substance abuse disorders (Brietzke et al, 2012;Duffy, 2012;Faedda et al, 2015;Tijssen et al, 2010b;Tijssen et al, 2010c). …”

Section: Introductionmentioning

confidence: 99%

The predictive value of childhood subthreshold manic symptoms for adolescent and adult psychiatric outcomes

Papachristou

Oldehinkel

Ormel

et al. 2017

Journal of Affective Disorders

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The Nature of the Association Between Childhood ADHD and the Development of Bipolar Disorder: A Review of Prospective High-Risk Studies

Abstract: While childhood ADHD does not appear to be part of the typical developmental illness trajectory of bipolar disorder, subjective problems with attention can form part of the early course, while neurodevelopmental abnormalities may be antecedents in a subgroup of high-risk children.

Cited by 90 publications

References 52 publications

Toward a Comprehensive Clinical Staging Model for Bipolar Disorder: Integrating the Evidence

Toward a Comprehensive Clinical Staging Model for Bipolar Disorder: Integrating the Evidence

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

The predictive value of childhood subthreshold manic symptoms for adolescent and adult psychiatric outcomes

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