The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis

Hogervorst, Eef; Williams, Jonathan; Budge, Marc; Riedel, Wim J.; Jolles, J.

doi:10.1016/s0306-4522(00)00410-3

Cited by 400 publications

(297 citation statements)

References 174 publications

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“…However, not all studies find beneficial effects of E 2 . Hormone therapy that results in very high or very low levels of E 2 produces impaired spatial ability, whereas mid-level E 2 is associated with improvement on tests of verbal, visual, and semantic memory compared to that of post-menopausal women given placebo [1,34,45]. Thus, beneficial effects of E 2 among women seem to be most readily observed in aging individuals that receive replacement with moderate E 2 concentrations.…”

Section: Introductionmentioning

confidence: 99%

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

2005

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Although 17β-Estradiol (E 2 ) improves cognitive performance of aged female mice, its mnemonic effects when administered post-training to aged male mice have not been examined. E 2 (10 µg, SC) or oil vehicle was administered to intact, 24-month-old female or male congenic (primarily C57BL/6 background) mice immediately after training in the inhibitory avoidance or water maze tasks. Following behavioral testing, effects of 1 or 24 h of E 2 exposure on hippocampal levels of E 2 and brain-derived neurotrophic factor (BDNF) were examined. Female and male mice administered E 2 showed significantly better performance in the inhibitory avoidance task than did vehicle-administered mice. When tested 24 h after training, mice that received E 2 had significantly longer latencies to cross-over to the shock-associated side of the chamber than did vehicleadministered mice. Female or male mice administered E 2 showed significantly better performance in the reference memory aspect of the spatial water maze task. When tested 30 min after training, mice administered E 2 had shorter latencies to, and spent longer swimming in, the quadrant that the hidden platform had previously been located in. E 2 administration produced physiological levels of E 2 in the hippocampus 1 and 24 h after E 2 . BDNF levels in the hippocampus were decreased following 1 h of E 2 exposure compared to vehicle. These findings suggest that E 2 to female and male mice may overcome age-related deficits in reference memory in an emotional or spatial learning task.

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Section: Introductionmentioning

confidence: 99%

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

2005

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“…Differences in estrogen response are possible depending on how recently the menopause took place. Although reviews and meta-analyses suggest a positive, albeit modest, effect of menopausal hormone therapy (HT) on verbal memory, attention, and reasoning, and associate it with a decreased risk of dementia (eg, Hogervorst et al, 2000;Rice and Morse, 2003), most reports also cite methodological differences across studies. For example, there may be adverse effects depending on the type of HT or timing of HT use (Espeland et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women

Amin

Gueorguieva

Cappiello

et al. 2006

Neuropsychopharmacol

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Despite an abundance of data in animals, there is little research in humans regarding how estrogen and serotonin (5-HT) may interact to influence cognition. Through the use of estrogen treatment (ET) and tryptophan depletion (TRP-D) in a within-subject design involving healthy menopausal women, we have manipulated both estrogen and 5-HT in order to evaluate their individual and joint effects. Although neither manipulation influenced visuospatial learning, a significant interaction suggested that estrogen exerted a protective effect on verbal memory, such that TRP-D impaired performance to a greater extent before the administration of ET. In consonance with this finding, ET was associated with a small, but positive mood effect on the day following active TRP-D. In addition, ET significantly improved letter-cued verbal fluency with and without TRP-D. Finally, time since last menstrual period was significantly associated with verbal memory scores, such that longer length of hypogonadism resulted in decreased verbal memory performance. These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition.

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“…In the Cache County, women with hormone use at any age exhibit slower rates of cognitive decline, particularly the women aged 85 years or older [15] . Meta analyses further suggest that hormone use induces a decrease in the rate of cognitive decline by 1/3 [16,17] . Moreover, longterm use of hormone induces a greater reduction in AD risk than short-term use [1] .…”

Section: Discussionmentioning

confidence: 99%

Effects of synaptic plasticity regulated by 17β-estradiol on learning and memory in rats with Alzheimer’s disease

et al. 2010

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Objective To investigate whether estrogen modulates learning and memory and long-term potentiation (LTP) in the hippocampus of rats with Alzheimer's disease (AD). Methods The rats were divided into ovariectomy (OVX) and estrogen replacement therapy (ERT) groups. Rats in the ERT group received OVX, followed by ERT, while rats in the OVX group received only OVX. The rat model of AD was established by injection of 1 μL (10 μg/μL) amyloid-beta peptide 1-40(Aβ 1-40 ) into the hippocampus. The learning and memory ability and LTP were determined by Morris water maze and electrophysiological method, respectively. Results The escape latency in Morris water maze significantly decreased in ERT group compared with that in OVX group (P < 0.05). Besides, rats in ERT group exhibited a significant enhancement of the magnitude of LTP at 30 min after high-frequency stimulation (HFS), compared with that in OVX group (P < 0.01). Conclusion ERT can attenuate the cognitive deficits in the rat model of AD, and estrogen can regulate LTP and synaptic remodeling in AD rats.

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The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis

Cited by 400 publications

References 174 publications

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

Estradiol to aged female or male mice improves learning in inhibitory avoidance and water maze tasks

Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women

Effects of synaptic plasticity regulated by 17β-estradiol on learning and memory in rats with Alzheimer’s disease

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