The Gaza Strip is in a chronic state of water shortage and the coastal aquifer as the only freshwater source is increasingly depleted and polluted, especially by nitrate. Assessment of groundwater vulnerability to pollution is essential for adequate protection and management. In this study, the assessment of the aquifer vulnerability to contamination is derived by applying the DRASTIC procedure, firstly with original default weights and ratings and, secondly, improved by estimating rating values by multiple linear regression of observed log-transformed nitrate concentration in groundwater, with DRASTIC factors extended to land-use. The results are very different because high and low vulnerability areas shift considerably. Subsequently, a geostatistical analysis of the spatial distribution of the nitrate concentration is performed, firstly by ordinary kriging interpolation of the observed nitrate concentration and secondly by regression kriging using DRASTIC factors and land-use as indicators of the spatial variation in nitrate occurrence. These maps differ because the map obtained by regression kriging interpolation shows much more details of environmental factors such as dunes, ridges, soil types and built-up areas that affect the presence of nitrate in groundwater. The results of this study can be used by the Palestinian authorities concerned with sustainable groundwater management in the Gaza Strip.