The near-infrared fluorescent dye IR-780 was coupled with cabazitaxel for castration-resistant prostate cancer imaging and therapy

Zheng, Yu; Hou, Guoqing; Zhang, Geng; Lan, Ting; Yuan, Jiarui; Zhang, Lei; Yan, Fei; Wang, Fuli; Meng, Ping; Dun, Xinlong; Li, Xian; Guo, Cheng; Zhu, Zheng; Wei, Di; He, Wei; Yuan, Jianlin

doi:10.1007/s10637-020-00934-1

Cited by 3 publications

(5 citation statements)

References 42 publications

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“…Previous reports have shown that the enhanced outcomes of combinational treatment with PTX and IR780 were associated with the promotion of tumor cell apoptosis via a prolonged G2 phase of the cell cycle and ROS-mediated PDT, which were in agreement with our findings [ 38 , 39 ]. Following exposure to NIR, PTX/IR780-HA&RBCm-LCNPs successfully induced A549 cells to produce a large amount of ROS, whereas without NIR irradiation, no obvious ROS production was observed (Fig.…”

Section: Resultssupporting

confidence: 93%

“…Photochemotherapy produced by the combination of PTX and IR780 has been shown to enhance antitumor effects [ 38 ]. For example, the cure rate of primary melanoma-bearing mice with intratumoral injection was 100% within 30 days [ 39 ]; IR780 was able to exert photothermal therapeutic effects on pancreatic ductal adenocarcinoma and expanded the tumor interstitial space to promote paclitaxel delivery to deep tumor tissues [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

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A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy

Zhang

Xia

et al. 2021

J Nanobiotechnol

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Background A red blood cell membrane (RBCm)-derived drug delivery system allows prolonged circulation of an antitumor treatment and overcomes the issue of accelerated blood clearance induced by PEGylation. However, RBCm-derived drug delivery systems are limited by low drug-loading capacities and the lack of tumor-targeting ability. Thus, new designs of RBCm-based delivery systems are needed. Results Herein, we designed hyaluronic acid (HA)–hybridized RBCm (HA&RBCm)-coated lipid multichambered nanoparticles (HA&RBCm-LCNPs) to remedy the limitations of traditional RBCm drug delivery systems. The inner core co-assembled with phospholipid-regulated glycerol dioleate/water system in HA&RBCm-LCNPs met the required level of blood compatibility for intravenous administration. These newly designed nanocarriers had a honeycomb structure with abundant spaces that efficiently encapsulated paclitaxel and IR780 for photochemotherapy. The HA&RBCm coating allowed the nanocarriers to overcome the reticuloendothelial system barrier and enhanced the nanocarriers specificity to A549 cells with high levels of CD44. These properties enhanced the combinatorial antitumor effects of paclitaxel and IR780 associated with microtubule destruction and the mitochondrial apoptotic pathway. Conclusions The multifunctional HA&RBCm-LCNPs we designed expanded the functionality of RBCm and resulted in a vehicle for safe and efficient antitumor treatment. Graphical abstract

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy

Zhang

Xia

et al. 2021

J Nanobiotechnol

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“…These strategies also endow CTX properties including active targeting, self-assembly, increased water solubility, and low systemic toxicity. Also, the novel connection of the NIR dye with CTX enables drug delivery monitoring in tissue (Zheng et al, 2019(Zheng et al, , 2020. In particular, the physical and chemical properties of some representative emerging CTX drug delivery systems are summarized in Table 1, and the anti-tumor efficacy in vitro and in vivo are listed in Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…Small‐molecule cabazitaxel prodrugs aim to improve drug solubility, chemical stability, bioavailability, targeting efficacy, and imaging properties (T. Li, Chen, et al, 2021; T. Liu et al, 2021; Lu et al, 2018; Shi et al, 2022; H. Wang et al, 2017; B. Xie et al, 2020; Z. Yang et al, 2020; Zheng et al, 2019, 2020). With the deep penetration ability at the emission wavelength of 700–1000 nm, near‐infrared (NIR) dyes have been widely used as tumor theranostic agents (E. Zhang et al, 2014).…”

Section: The Development Of Cabazitaxel Formulationsmentioning

confidence: 99%

“…With the deep penetration ability at the emission wavelength of 700-1000 nm, near-infrared (NIR) dyes have been widely used as tumor theranostic agents (E. Zhang et al, 2014). Zheng et al reported IR-780 dye coupled with cabazitaxel and explored its suitability for the imaging and chemotherapy of cancer (Zheng et al, 2019(Zheng et al, , 2020. They found the coupled-molecule was more efficiently up-taken in cancer cells than dyes or cabazitaxel alone.…”

Section: Small-molecule Prodrugsmentioning

confidence: 99%

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Current development of cabazitaxel drug delivery systems

Sun

Lovell

Zhang

2022

WIREs Nanomed Nanobiotechnol

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The second-generation taxane cabazitaxel has been clinically approved for the treatment of metastatic castration-resistant prostate cancer after docetaxel failure. Compared with the first-generation taxanes paclitaxel and docetaxel, cabazitaxel has potent anticancer activity and is less prone to drug resistance due to its lower affinity for the P-gp efflux pump. The relatively high hydrophobicity of cabazitaxel and the poor aqueous colloidal stability of the commercial formulation, following its preparation for injection, presents opportunities for new cabazitaxel formulations with improved features. This review provides an overview of cabazitaxel drug formulations and hydrophobic taxane drug delivery systems in general, and particularly focuses on emerging cabazitaxel delivery systems discovered in the past 5 years.

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Oxygen‐sufficient lipid nanobubbles combined with UTMD for enhanced sonodynamic therapy of Hep‐G2 cells

et al. 2021

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Sonodynamic therapy (SDT) is an emerging noninvasive therapeutic approach, which could penetrate deep‐seated tissues and activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS). Nevertheless, the hypoxic tumor microenvironment significantly limits the efficiency of SDT due to its oxygen‐consumption treatment principle. To break hypoxia‐induced resistance and improve the efficacy of SDT, we developed shell‐core structured oxygen‐sufficient nanobubbles(NBs), which were designed with a lipid shell loaded the sonosensitizer IR780 and a gas core loaded with oxygen. With the aid of ultrasound‐targeted microbubble destruction (UTMD), IR780@O2 NBs not only make sonosensitizers more effectively enriched at the tumor site in a controlled manner, but also directly mediate oxygen release and provide sufficient oxygen for producing more ROS to induce cell apoptosis. Thus, IR780@O2 NBs can efficiently inhibit the proliferation of Hep‐G2 cells under ultrasound exposure. What is more, IR780@O2 NBs have a potential for contrast enhanced ultrasound (CEUS) imaging. We believe that our oxygen‐sufficient NBs trigged by UTMD could be an ideal therapeutic and imaging system for hepatocellular carcinoma.

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The near-infrared fluorescent dye IR-780 was coupled with cabazitaxel for castration-resistant prostate cancer imaging and therapy

Cited by 3 publications

References 42 publications

A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy

A novel multi-functionalized multicellular nanodelivery system for non-small cell lung cancer photochemotherapy

Current development of cabazitaxel drug delivery systems

Oxygen‐sufficient lipid nanobubbles combined with UTMD for enhanced sonodynamic therapy of Hep‐G2 cells

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