The need for a consensus in the use of assessment tools for Alzheimer's disease: the Feasibility Study (assessment tools for dementia in Alzheimer Centres across Europe), a European Alzheimer's Disease Consortium's (EADC) survey

Díaz, S.P. Ramírez; Gregório, Pedro Gil; Casado, José Manuel Ribera; Reynish, Emma; Ousset, Pierre Jean; Vellas, Bruno; Salmon, Eric

doi:10.1002/gps.1355

Cited by 39 publications

(22 citation statements)

References 29 publications

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“…Harmonisation recommendations have been proposed in the case of vascular cognitive impairment [3]. In the case of NDD, surveys of assessment tools for the most common NDD, Alzheimer’s disease (AD), used across Europe have been published by the European AD consortium [4] and by a task force of the European Federation of Neurological Societies [5], demonstrating a wide variety in assessment tools. In the last few years, the development of new diagnostic criteria for AD [6, 7], posterior cortical atrophy [8], frontotemporal dementia - behavioural variant [9], and primary progressive aphasia [10] all include a consideration of recommended, disease-specific testing procedures aiming at early diagnosis—although precise details of specific tests are often lacking, meaning that test selection is open to interpretation and, therefore, to potential inconsistency.…”

Section: Introductionmentioning

confidence: 99%

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

et al. 2017

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Cognitive, behavioural, and functional assessment is crucial in longitudinal studies of neurodegenerative dementias (NDD). Central issues, such as the definition of the study population (asymptomatic, at risk, or individuals with dementia), the detection of change/decline, and the assessment of relevant outcomes depend on quantitative measures of cognitive, behavioural, and functional status.Currently, we are far from having available reliable protocols and tools for the assessment of dementias in Europe. The main problems are the heterogeneity of the tools used across different European countries, the lack of standardisation of administration and scoring methods across centres, and the limited information available about the psychometric properties of many tests currently in widespread use. This situation makes it hard to compare results across studies carried out in different centres, thus hampering research progress, in particular towards the contribution to a “big data” common data set.We present here the results of a project funded by the Joint Program for Neurodegenerative Diseases (JPND) and by the Italian Ministry of Health. The project aimed at providing a consensus framework for the harmonisation of assessment tools to be applied to research in neurodegenerative disorders affecting cognition across Europe. A panel of European experts reviewed the current methods of neuropsychological assessment, identified pending issues, and made recommendations for the harmonisation of neuropsychological assessment of neurodegenerative dementias in Europe.A consensus was achieved on the general recommendations to be followed in developing procedures and tools for neuropsychological assessment, with the aim of harmonising tools and procedures to achieve more reliable data on the cognitive-behavioural examination. The results of this study should be considered as a first step to enhancing a common view and practise on NDD assessment across European countries.

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Section: Introductionmentioning

confidence: 99%

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

et al. 2017

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“…Specific drugs are only modestly effective in preventing functional decline and do not obviate the need for caregiving [3,4] . The Katz and Lawton scales are widely used for assessment of functional decline in AD, and the average yearly decline is 2 points out of 14 on the Lawton scale [5,6] . Activities of daily living (ADL) are divided into basic (BADL) and more complex activities called instrumental ADL (IADL).…”

Section: Introductionmentioning

confidence: 99%

Patterns of Loss of Basic Activities of Daily Living in Alzheimer Patients: A Cross-Sectional Study of the French REAL Cohort

Lechowski

Pradelles²,

Crane³

et al. 2010

Dement Geriatr Cogn Disord

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Background/Aims: To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer’s disease (AD) community-dwelling patients included in the French REAL cohort. Methods: Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion using the Lawton scale. Results: With 6 binary BADL scores, each patient presented at inclusion a set of losses. For 53% of women, the sets of losses were included within each other or were identical, adding losses in physical ambulation, grooming, bathing, dressing, toilet and feeding, respectively. For 47% of men, a similar sequence was identified, with loss of dressing occurring secondly. A global cohesion of sets of losses was found for 87% of women and 86% of men. The Lawton scale is very useful for the assessment of AD patients.

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“…In a review of European centers, for example, 40-50% of sites used the CDR and an ADL measure and 20% used the NPI [46]. In a review of European centers, for example, 40-50% of sites used the CDR and an ADL measure and 20% used the NPI [46].…”

Section: Site-related Factors To Be Considered In Globalized Trialsmentioning

confidence: 99%

Challenges and Opportunities to Conduct Global Alzheimer’s Disease Clinical Trials

Cummings

Zhong

2014

Global Clinical Trials for Alzheimer's Disease

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The need for a consensus in the use of assessment tools for Alzheimer's disease: the Feasibility Study (assessment tools for dementia in Alzheimer Centres across Europe), a European Alzheimer's Disease Consortium's (EADC) survey

Cited by 39 publications

References 29 publications

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group

Patterns of Loss of Basic Activities of Daily Living in Alzheimer Patients: A Cross-Sectional Study of the French REAL Cohort

Challenges and Opportunities to Conduct Global Alzheimer’s Disease Clinical Trials

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