The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disorders

Singer, Harvey S.; Hong, John J; Rippel, Christopher A.; Pardo, C A

doi:10.1136/adc.2003.046847

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…39 The entity of PANDAS remains an intriguing but controversial clinical syndrome. [40][41][42][43][44][45] Several findings raise concerns about PANDAS being an autoimmune-mediated process, including the failure to detect specific antibodies in this and other 13 studies, methodologic issues with the single immunomodulatory treatment study, 46,47 and the failure of microinfused PANDAS sera into ventral and ventrolateral rodent striatum to produce changes in animal behavior. 48 …”

Section: Discussionmentioning

confidence: 99%

Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls

et al. 2005

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“…11 Thus, anti-basal antibodies should not be used yet for diagnostic purposes. 12 Our patient fits the original description of von Economo Encephalitis. Actually, the clinical onset may well correspond to the less common ''amyostaticakinetic'' form and the last clinical picture to the ''somnolent-ophthalmoplegic'' form of this disease.…”

Section: Discussionmentioning

confidence: 76%

From juvenile parkinsonism to encephalitis lethargica, a new phenotype of post-streptococcal disorders: Case report

Beleza

Soares-Fernandes

Jordão

et al. 2008

European Journal of Paediatric Neurology

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a b s t r a c tWe report the case of a 16-year-old boy presented with a mild akinetic-rigid parkinsonism shortly after a post-streptococcal infection. After stopping corticoids, he had a rapid neurological deterioration to a fatal encephalitis lethargica-like syndrome. Serum analysis demonstrated consistently elevated anti-streptolysin-O. This case illustrates a new severe phenotype in the spectrum of the post-streptococcal disorders. This etiology should be considered in the differential diagnosis of a movement disorder with a rapid detrimental evolution.

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“…Antibasal ganglia antibodies (ABGA) have been detected in 100% and 69% of patients with acute and convalescent SC, respectively, compared to 12% in patients with RF without chorea, and 0% of healthy controls 17. However, the role of these antibodies as pathogenic or simply epiphenomenon is yet to be established 18, 19. Anti‐tubulin β antibodies have been recently identified in patients with SC 20.…”

Section: Autoimmune Neuropsychiatric Disorders Associated With Streptmentioning

confidence: 99%

Movement disorders in autoimmune diseases

2012

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Movement disorders have been known to be associated with a variety of autoimmune diseases, including Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, systemic lupus erythematosus, antiphospholipid syndrome, gluten sensitivity, paraneoplastic and autoimmune encephalopathies. Tremors, dystonia, chorea, ballism, myoclonus, parkinsonism, and ataxia may be the initial and even the only presentation of these autoimmune diseases. Although antibodies directed against various cellular components of the central nervous system have been implicated, the pathogenic mechanisms of these autoimmune movement disorders have not yet been fully elucidated. Clinical recognition of these autoimmune movement disorders is critically important as many improve with immunotherapy or dietary modifications, particularly when diagnosed early. We discuss here the clinical features, pathogenic mechanisms, and treatments of movement disorders associated with autoimmune diseases, based on our own experience and on a systematic review of the literature.

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The need for caution in considering the diagnostic utility of antibasal ganglia antibodies in movement disorders

Cited by 13 publications

References 19 publications

Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls

Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls

From juvenile parkinsonism to encephalitis lethargica, a new phenotype of post-streptococcal disorders: Case report

Movement disorders in autoimmune diseases

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