The need for registry‐based studies in diabetes and stroke: A unique opportunity to understand whether diabetic treatments improve post‐stroke outcome

Darsalia, Vladimer; Vercalsteren, Ellen; Karampatsi, Dimitra; Romanitan, Mihaela Oana; Mazya, Michael V.; Nyström, Thomas; Patrone, Cesare

doi:10.1111/dom.15577

Diabetes Obesity Metabolism

2024

DOI: 10.1111/dom.15577

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The need for registry‐based studies in diabetes and stroke: A unique opportunity to understand whether diabetic treatments improve post‐stroke outcome

Vladimer Darsalia,

Ellen Vercalsteren,

Dimitra Karampatsi

et al.

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Comparing clinical outcomes in patients with type 2 diabetes mellitus after ischaemic stroke: Sodium–glucose cotransporter 2 inhibitors users versus non‐users. A propensity score matching National Cohort Study

Chen,

Lee,

Chan

et al. 2024

Diabetes Obesity Metabolism

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AimThis nationwide cohort study evaluated the impact of sodium–glucose co‐transporter‐2 inhibitors (SGLT2i) on patients with type 2 diabetes mellitus (T2DM) after ischaemic stroke (IS), aiming to compare clinical outcomes between SGLT2i‐treated patients and those not receiving SGLT2i.Materials and MethodsUtilizing Taiwan's National Health Insurance Research Database, we identified 707 patients with T2DM treated with SGLT2i and 27 514 patients not treated with SGLT2i after an IS, respectively, from 1 May 2016 to 31 December 2019. Propensity score matching was applied to balance baseline characteristics. The follow‐up period extended from the index date (3 months after the index acute IS) until the independent occurrence of the study outcomes, 6 months after discontinuation of the index drug, or the end of the study period (31 December 2020), whichever came first.ResultsAfter propensity score matching, compared with the non‐SGLT2i group (n = 2813), the SGLT2i group (n = 707) exhibited significantly lower recurrent IS rates (3.605% per year vs. 5.897% per year; hazard ratio: 0.55; 95% confidence interval: 0.34–0.88; p = 0.0131) and a significant reduction in all‐cause mortality (5.396% per year vs. 7.489% per year; hazard ratio: 0.58; 95% confidence interval: 0.39–0.85; p = 0.0058). No significant differences were observed in the rates of acute myocardial infarction, cardiovascular death, heart failure hospitalization, or lower limb amputation.ConclusionsOur findings indicate significantly lower risks of recurrent IS and all‐cause mortality among patients with T2DM receiving SGLT2i treatment. Further studies are required to validate these results and investigate the underlying mechanisms behind the observed effects.

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Comparing clinical outcomes in patients with type 2 diabetes mellitus after ischaemic stroke: Sodium–glucose cotransporter 2 inhibitors users versus non‐users. A propensity score matching National Cohort Study

Chen,

Lee,

Chan

et al. 2024

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

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The need for registry‐based studies in diabetes and stroke: A unique opportunity to understand whether diabetic treatments improve post‐stroke outcome

Cited by 1 publication

References 25 publications

Comparing clinical outcomes in patients with type 2 diabetes mellitus after ischaemic stroke: Sodium–glucose cotransporter 2 inhibitors users versus non‐users. A propensity score matching National Cohort Study

Comparing clinical outcomes in patients with type 2 diabetes mellitus after ischaemic stroke: Sodium–glucose cotransporter 2 inhibitors users versus non‐users. A propensity score matching National Cohort Study

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