The negative impact of most relevant infections on fertility and assisted reproduction technology

Carbone, Luigi; Conforti, Alessandro; Marca, Antonio La; Cariati, Federica; Vallone, Roberta; Raffone, Antonio; Buonfantino, Cira; Palese, Michela; Mascia, Marika; Girolamo, Raffaella Di; Capuzzo, Martina; Esteves, Sandro C.

doi:10.23736/s2724-606x.21.04870-3

Cited by 19 publications

(10 citation statements)

References 253 publications

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“…Interestingly, during the lockdown period, a significant decrease in admissions to the emergency units was also found for obstetric-gynecological conditions [16][17][18][19][20][21], and even for important tests, such as invasive prenatal diagnosis, a drop in the number of procedures was noted [22], clearly showing that pregnant women were more concerned than others of contracting the infection and suffering from the COVID-19 disease [23,24]. Moreover, reproductive medicine had to cease treatment unless for fertility preservation due to oncologic reasons, with consequences also on fertility and natality rates, opening a debate on the urgency to reduce time to pregnancy in women with poor prognosis [25][26][27][28][29]. Very soon, it appeared clear that pregnant women should have been considered a population at increased risk for severe forms of infection and therefore adverse maternal and perinatal outcomes [30][31][32][33][34][35][36][37].…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Guida¹,

Carbone²,

Ferrara³

et al. 2022

It Journ Gyn Obs

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Background:The aim of this study was to evaluate maternal and perinatal outcomes of pregnant women affected by COVID-19 during the first pandemic wave in a third level university hospital of southern Italy. Methods:This was a single-center, cohort study on SARS-CoV-2 in pregnancy. Pregnant women with laboratory-confirmed SARS-COV-2 from August 1, 2020 to January 1, 2021 from University of Naples Federico II were included in the study. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was the incidence preterm birth.Results: 249 singleton pregnancies, positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab, were included in the study. Mean gestational age at diagnosis was 31.0 ± 6.7 weeks, with 2.4% of women being diagnosed in the first, 14.1% in the second and 83.5% in the third trimester of pregnancy. The vast majority of the women received therapy with low molecular weight heparin (88.8%). 47 women (18.9%) required oxygen therapy. The rate of admission to the maternal intensive care unit was 2.8%. There was one case of maternal death, accounting for a maternal mortality rate of 0.4%. Out of the 249 ended pregnancies, we reported two spontaneous abortions and two stillbirths. Among the 245 live-born babies, no neonatal deaths were recorded. All babies were tested negative at RT-PCR nasal and pharyngeal swab. The incidence of preterm delivery before 37 weeks was 10%.Conclusion: SARS-COV-2 infection in pregnant women during the first pandemic wave in the South of Italy was associated with relative low rates of maternal and perinatal adverse outcome.

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Guida¹,

Carbone²,

Ferrara³

et al. 2022

It Journ Gyn Obs

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“…On the other hand, pelvic infections, such as chlamydia, mycoplasma, and ureaplasma, seem to be related to a longer period to achieve pregnancy and increased rates of pregnancy loss [17,18]. Bacterial vaginosis has also been considered an obstetrical and gynecological issue, and the link between bacterial vaginosis and preterm birth has been intensely studied.…”

Section: Discussionmentioning

confidence: 99%

Report of Two Cases of Pelvic Inflammatory Disease Complicating Transcervical Frozen Embryo Transfer

Vielba¹,

Sierra²,

Molina³

et al. 2023

Clin. Exp. Obstet. Gynecol.

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Background: Pelvic inflammatory disease (PID) complicating transcervical embryo transfer, not related to previous oocyte aspiration, is an extremely rare event. However, it can lead to severe complications. Case: We report two cases of pelvic infection related to transcervical frozen embryo transfer. The case of one patient was complicated by a pelvic abscess, which required percutaneous drainage, and the case of the other patient was complicated by ascites, which was positive for chlamydia. Conclusions: Despite there not being enough evidence to recommend cervical cultures or antibiotic prophylaxis in all cases of embryo transfer, it would be advisable in those cases with a personal history of PID.

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“…The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that was first identified in December 2019 remains a major public health issue [ 1 , 2 ]. Obstetrics and gynecology practice has undergone many changes during the last 2 years [ 3 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Do Anti-SARS-CoV-2 Monoclonal Antibodies Have an Impact on Pregnancy Outcome? A Systematic Review and Meta-Analysis

et al. 2023

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Monoclonal antibodies (mAbs) have been used as a rescue strategy for pregnant women affected by COVID-19. To explore its impact on maternal-fetal health, we included all observational studies reporting maternal, fetal, delivery and neonatal outcomes in women who underwent mAbs infusion for COVID-19. Primary outcome was the percentage of preterm delivery. We used meta-analyses of proportions to combine data for maternal, fetal, delivery and neonatal outcome of women treated with mAbs for COVID-19 and reported pooled proportions and their 95% confidence intervals (CIs) for categorical variables or mean difference (MD) with their 95% confidence intervals for continuous variables. Preterm birth was observed in 22.8% of cases (95% CI 12.9–34.3). Fetal distress was reported in 4.2% (95% CI 1.6–8.2). Gestational hypertension and pre-eclampsia were observed in 3.0% (95% CI 0.8–6.8) and 3.4% (95% CI 0.8–7.5) of cases, respectively. Fetal growth restriction was observed in 3.2% of fetuses (95% CI 0.8–7.0). Secondary prophylaxis with mAbs is currently considered the best treatment option for people with mild to moderate COVID-19 disease. More attention should be paid to infants born from mothers who were treated with mAbs, for the risk of immunosuppression.

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The negative impact of most relevant infections on fertility and assisted reproduction technology

Cited by 19 publications

References 253 publications

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Report of Two Cases of Pelvic Inflammatory Disease Complicating Transcervical Frozen Embryo Transfer

Do Anti-SARS-CoV-2 Monoclonal Antibodies Have an Impact on Pregnancy Outcome? A Systematic Review and Meta-Analysis

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