The negative impact of pain catastrophising on disease activity: analyses of data derived from patient-reported outcomes in psoriatic arthritis and axial spondyloarthritis

Currado, Damiano; Biaggi, Alice; Pilato, Andrea; Marino, Annalisa; Ruscitti, Piero; Pantano, Ilenia; Donato, Stefano Di; Vomero, Marta; Berardicurti, Onorina; Pavlych, Viktoriya; Vico, Claudio Di; Caso, Francesco; Costa, Luisa; Tasso, Marco; Camarda, Federica; Misceo, Francesca; Vincenzo, Francesco De; Corrado, Addolorata; Cantatore, Francesco Paolo; Perosa, Federico; Guggino, Giuliana; Scarpa, Raffaele; Cipriani, Paola; Ciccia, Francesco; Giacomelli, Roberto; Navarini, Luca

doi:10.55563/clinexprheumatol/r0kgp8

Cited by 6 publications

(5 citation statements)

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“…It was observed that a high level of the Pain Catastrophizing Scale was associated with a high level of disease activity (89). This study suggests that many psychometric variables that are independent of the inflammatory process are able to influence patients' perception of the disease (and related patient outcome measures), significantly impacting the achievement of remission or LDA in inflammatory arthritis (89). Further studies (e.g., mediation analysis) are needed to confirm this hypothesis.…”

Section: Pain In Axspamentioning

confidence: 80%

“…In another multicenter observational study, the negative impact of pain catastrophizing on disease activity in patients with psoriatic arthritis (N = 135) and axSpA (N = 71) was evaluated. It was observed that a high level of the Pain Catastrophizing Scale was associated with a high level of disease activity (89). This study suggests that many psychometric variables that are independent of the inflammatory process are able to influence patients' perception of the disease (and related patient outcome measures), significantly impacting the achievement of remission or LDA in inflammatory arthritis (89).…”

Section: Pain In Axspamentioning

confidence: 83%

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Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Selmi,

Chimenti,

Novelli

et al. 2024

Front. Immunol.

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Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that is characterized by new bone formation in the axial musculoskeletal system, with X-ray discriminating between radiographic and non-radiographic forms. Current therapeutic options include non-steroidal anti-inflammatory drugs in addition to biological disease-modifying anti-rheumatic drugs that specifically target tumor necrosis factor-alpha (TNFα) or interleukin (IL)-17. Pain is the most critical symptom for axSpA patients, significantly contributing to the burden of disease and impacting daily life. While the inflammatory process exerts a major role in determining pain in the early phases of the disease, the symptom may also result from mechanical and neuromuscular causes that require complex, multi-faceted pharmacologic and non-pharmacologic treatment, especially in the later phases. In clinical practice, pain often persists and does not respond further despite the absence of inflammatory disease activity. Cytokines involved in axSpA pathogenesis interact directly/indirectly with the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling cascade, a fundamental component in the origin and development of spondyloarthropathies. The JAK/STAT pathway also plays an important role in nociception, and new-generation JAK inhibitors have demonstrated rapid pain relief. We provide a comprehensive review of the different pain types observed in axSpA and the potential role of JAK/STAT signaling in this context, with specific focus on data from preclinical studies and data from clinical trials with JAK inhibitors.

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Section: Pain In Axspamentioning

confidence: 80%

Section: Pain In Axspamentioning

confidence: 83%

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Selmi,

Chimenti,

Novelli

et al. 2024

Front. Immunol.

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“…In study by Currado et al [ 67 ], the impact of pain catastrophizing was investigated in a cohort of 135 PsA patients, with 29.6% having concomitant fibromyalgia. Participants with a Disease Activity in Psoriatic Arthritis (DAPSA) score greater than 14 (the cut-off score between low and moderate activity) demonstrated notably higher scores related to pain catastrophizing.…”

Section: Search Methodologymentioning

confidence: 99%

“…Other studies have indicated a correlation between PCS and elevated composite disease activity scores, such as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), emphasising the impact of maladaptive cognitive pain perception on achieving low disease activity and remission [ 54 , 67 ]. Despite effective treatment of inflammation, individuals with possible central sensitisation may retain high disease activity scores.…”

Section: Search Methodologymentioning

confidence: 99%

Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications

Wilk,

Zimba,

Haugeberg

et al. 2024

Rheumatol Int

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Pain is a crucial factor in rheumatic disorders, and reducing it is a primary goal of successful treatment. Adaptive pain-coping strategies can enhance this improvement, but maladaptive approaches such as pain catastrophizing may worsen overall patient well-being. This narrative review aims to provide a concise overview of the existing knowledge on pain catastrophizing in the most prevalent specific rheumatic disorders. The objective of this study was to improve understanding of this phenomenon and its implications, as well as to pinpoint potential directions for future research. We conducted searches in the MEDLINE/PubMed, SCOPUS, and DOAJ bibliography databases to identify articles related to pain catastrophizing in rheumatoid arthritis, psoriatic arthritis, axial spondylarthritis, systemic sclerosis, systemic lupus erythematosus, Sjögren’s syndrome, juvenile idiopathic arthritis, and osteoarthritis (non-surgical treatment). Data extraction was performed on November 1, 2023. The investigators screened the identified articles to determine their relevance and whether they met the inclusion criteria. Following a bibliography search, which was further expanded by screening of citations and references, we included 156 records in the current review. The full-text analysis centred on pain catastrophizing, encompassing its prevalence, pathogenesis, and impact. The review established the role of catastrophizing in amplifying pain and diminishing various aspects of general well-being. Also, potential treatment approaches were discussed and summarised across the examined disorders. Pain catastrophizing is as a significant factor in rheumatic disorders. Its impact warrants further exploration through prospective controlled trials to enhance global patient outcomes.

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“…Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases involving the joints, characterized by shared genetic background as well as similar clinical manifestations and comorbidities [1]. Both PsA and axSpA are associated with decreased quality of life, loss of workability, and significant impairment of physical, psychological, and social functioning [2,3].…”

Section: Introductionmentioning

confidence: 99%

Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study

Marino,

Currado,

Altamura

et al. 2024

Biomedicines

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Background: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) are inflammatory diseases with shared genetic backgrounds and clinical comorbidities. Headache, a common global health issue, affects over 50% of adults and encompasses various types, including migraine, tension-type, and cluster headaches. Migraine, the most prevalent, recurrent, and disabling type, is often associated with other medical conditions such as depression, epilepsy, and psoriasis, but little is known about the relationship between autoimmune disease and the risk of migraine. Methods: A cross-sectional study was conducted from July to November 2022, enrolling 286 participants, including 216 with PsA, 70 with axSpA, and 87 healthy controls. Results: Headache prevalence was significantly higher in the PsA (39.81%) and axSpA (45.71%) patients compared to the healthy controls. The prevalence of migraine without aura was also significantly higher in both the PsA (18.52%) and axSpA (28.57%) groups compared to the healthy controls. Conclusions: These findings underscore the high burden of headache and migraine in PsA and axSpA participants, highlighting the need for improved management and treatment strategies for these patients.

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The negative impact of pain catastrophising on disease activity: analyses of data derived from patient-reported outcomes in psoriatic arthritis and axial spondyloarthritis

Cited by 6 publications

References 0 publications

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications

Increased Prevalence of Headaches and Migraine in Patients with Psoriatic Arthritis and Axial Spondyloarthritis: Insights from an Italian Cohort Study

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