The Negative Syndrome as a Dimension: Factor Analyses of PANSS in Major Depressive Disorder and Organic Brain Disease Compared With Negative Syndrome Structures Found in the Schizophrenia Literature

Milak, Matthew S.; Aniskin, Dmitry B.; Eisenberg, Daniel; Prikhojan, Alexander; Cohen, Lisa J.; Yard, Samantha; Galynker, Igor

doi:10.1097/wnn.0b013e3180653c35

Cited by 16 publications

(17 citation statements)

References 48 publications

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“…However, given that 39% of participants had a primary diagnosis of schizophrenia, while 34% had a diagnosis of bipolar disorder and 27% had a diagnosis of major depressive disorder, the fact that the HRQoL preference weights were developed for schizophrenic health states identified via the PANSS is a limitation, as is the fact that, to the best of our knowledge, the mapping function has only been applied to and tested on individuals with a primary diagnosis of schizophrenia (Heeg et al, 2008; Järbrink et al, 2009; Lenert et al, 2005; Rabinowitz et al, 2013). Although, as discussed above, studies have shown similarities between schizophrenia and bipolar and major depressive disorders with regard to the psychotic symptom domains identified by the PANSS (Daneluzzo et al, 2002; Eisenberg et al, 2009; Lindenmayer et al, 2007, 2004; Milak et al, 2007; Purnine et al, 2000). Moreover, we only observed significant group differences on PANSS ratings related to mood lability, rather than psychotic symptoms, in a sample that was primarily mood disordered.…”

Section: Discussionmentioning

confidence: 96%

“…The PANSS was originally developed to measure symptom severity among individuals with schizophrenia, but it is also commonly used as a psychotic symptom assessment tool for individuals with mood disorders given that it assesses symptoms associated with such disorders, such as mood lability, depressed mood and hostility. Studies have shown the PANSS to identify similar psychotic symptom domains between patients with schizophrenia and bipolar disorder (Daneluzzo et al, 2002; Lindenmayer et al, 2007, 2004), and between schizophrenia and major depressive disorder (Eisenberg et al, 2009; Milak et al, 2007; Purnine et al, 2000) – the three serious mental disorders with which participants had been diagnosed. However, before the PANSS scores can be used to weight life years, they must be linked to a measure of utility and converted to the aforementioned 0-1 health-utility index.…”

Section: Methodsmentioning

confidence: 99%

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An economic evaluation of a contingency-management intervention for stimulant use among community mental health patients with serious mental illness

Murphy¹,

McDonell²,

McPherson³

et al. 2015

Drug and Alcohol Dependence

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Background This study examines the cost-effectiveness of contingency-management (CM) for stimulant dependence among community mental health patients with serious mental illness (SMI). Methods Economic evaluation of a 12-week randomized controlled trial investigating the efficacy of CM added to treatment-as-usual (CM+TAU), relative to TAU without CM, for treating stimulant dependence among patients with a SMI. The trial included 176 participants diagnosed with SMI and stimulant dependency who were receiving community mental health and addiction treatment at one community mental health center in Seattle, Washington. Participants were also assessed during a 12-week follow-up period. Positive and negative syndrome scale (PANSS) scores were used to calculate quality-adjusted life-years (QALYs) for the primary economic outcome. The primary clinical outcome, the stimulant-free year (SFY) is a weighted measure of time free from stimulants. Two perspectives were adopted, those of the provider and the payer. Results At 12-weeks neither the provider ($2,652, p=.74) nor the payer ($2,611, p=.99) cost differentials were statistically significant. This was also true for the payer at 24-weeks (-$125, p=1.00). QALYs gained were similar across groups, resulting in small, insignificant differences (0.04, p=0.23 at 12-weeks; .01, p=0.70 at 24 weeks). CM+TAU experienced significantly more SFYs, 0.24 (p<0.001) at 12 weeks and 0.20 (p=0.002) at 24 weeks, resulting in at least an 85% chance of being considered cost-effective at a threshold of $200,000/SFY. Conclusion Contingency management appears to be a wise investment for both the provider and the payer with regard to the clinical outcome of time free from stimulants.

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Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

An economic evaluation of a contingency-management intervention for stimulant use among community mental health patients with serious mental illness

Murphy¹,

McDonell²,

McPherson³

et al. 2015

Drug and Alcohol Dependence

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“…The PANSS is widely used in patients with neuropsychiatric symptoms, and it has been found to have good sensitivity and specificity for psychosis and schizophrenia 25–27,29…”

Section: Methodsmentioning

confidence: 99%

“…A commonly used and validated clinical scale was used to find psychosis and schizophrenia symptoms (the Positive and Negative Symptom Scale [PANSS]), which quantifies the broad spectrum of psychotic symptoms including positive and negative psychotic symptoms and formal thought disorders 23,24. As the PANSS is originally developed to prospectively evaluate psychotic symptomatology over time, it also includes a general subscale, wherein symptoms such as tension and anxiety are included 25–27. The aim of the present study was to define psychotic symptoms in patients with probable and definite bvFTD in comparison with patients with a psychiatric disorder, all exhibiting a late-onset frontal lobe (LOF) syndrome.…”

Section: Introductionmentioning

confidence: 99%

Psychosis in behavioral variant frontotemporal dementia

Gossink¹,

Vijverberg²,

Krudop³

et al. 2017

NDT

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BackgroundDementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer’s disease. However, for behavioral variant of frontotemporal dementia (bvFTD), studies on the broad spectrum of psychotic symptoms are still lacking. The aim of this study was to systematically and prospectively subtype the wide spectrum of psychotic symptoms in probable and definite bvFTD.MethodsIn this study, a commonly used and validated clinical scale that quantifies the broad spectrum of psychotic symptoms (Positive and Negative Symptom Scale) was used in patients with probable and definite bvFTD (n=22) and with a primary psychiatric disorder (n=35) in a late-onset frontal lobe cohort. Median symptom duration was 2.8 years, and the patients were prospectively followed for 2 years.ResultsIn total, 22.7% of bvFTD patients suffered from delusions, hallucinatory behavior, and suspiciousness, although the majority of the patients exhibited negative psychotic symptoms such as social and emotional withdrawal and blunted affect (95.5%) and formal thought disorders (81.8%). “Difficulty in abstract thinking” and “stereotypical thinking” (formal thought disorders) differentiated bvFTD from psychiatric disorders. The combined predictors difficulty in abstract thinking, stereotypical thinking, “anxiety”, “guilt feelings,” and “tension” explained 75.4% of variance in the diagnosis of bvFTD versus psychiatric diagnoses (P<0.001).ConclusionDelusions, hallucinatory behavior, and suspiciousness were present in one-fifth of bvFTD patients, whereas negative psychotic symptoms such as social and emotional withdrawal, blunted affect, and formal thought disorders were more frequently present. This suggests that negative psychotic symptoms and formal thought disorders have an important role in the psychiatric misdiagnosis in bvFTD; misdiagnosis in bvFTD might be reduced by systematically exploring the broad spectrum of psychiatric symptoms.

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“…We chose a measure of negative symptoms as this concept encompasses areas that are highly relevant for MT: the ability (or its absence) to express oneself emotionally (affective flattening), the ability to form and sustain satisfactory relationships (anhedonia/asociality) and general motivation (avolition/apathy). Although negative symptoms are usually associated with schizophrenia, there is evidence that they are relevant for other disorders as well, notably for affective disorders [33,34,35,36,37]. Negative symptoms in themselves are strongly predictive of a need for care, irrespective of the primary diagnosis or whether the negative symptoms are considered primary or secondary [38].…”

Section: Methodsmentioning

confidence: 99%

Individual Music Therapy for Mental Health Care Clients with Low Therapy Motivation: Multicentre Randomised Controlled Trial

Gold

Mössler

Grocke

et al. 2013

Psychother Psychosom

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Background: Music therapy (MT) has been shown to be efficacious for mental health care clients with various disorders such as schizophrenia, depression and substance abuse. Referral to MT in clinical practice is often based on other factors than diagnosis. We aimed to examine the effectiveness of resource-oriented MT for mental health care clients with low motivation for other therapies. Method: This was a pragmatic parallel trial. In specialised centres in Norway, Austria and Australia, 144 adults with non-organic mental disorders and low therapy motivation were randomised to 3 months of biweekly individual, resource-oriented MT plus treatment as usual (TAU) or TAU alone. TAU was typically intensive (71% were inpatients) and included the best combination of therapies available for each participant, excluding MT. Blinded assessments of the Scale for the Assessment of Negative Symptoms (SANS) and 15 secondary outcomes were collected before randomisation and after 1, 3 and 9 months. Changes were analysed on an intention-to-treat basis using generalised estimating equations in longitudinal linear models, controlling for diagnosis, site and time point. Results: MT was superior to TAU for total negative symptoms (SANS, d = 0.54, p < 0.001) as well as functioning, clinical global impressions, social avoidance through music, and vitality (all p < 0.01). Conclusion: Individual MT as conducted in routine practice is an effective addition to usual care for mental health care clients with low motivation.

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The Negative Syndrome as a Dimension: Factor Analyses of PANSS in Major Depressive Disorder and Organic Brain Disease Compared With Negative Syndrome Structures Found in the Schizophrenia Literature

Cited by 16 publications

References 48 publications

An economic evaluation of a contingency-management intervention for stimulant use among community mental health patients with serious mental illness

An economic evaluation of a contingency-management intervention for stimulant use among community mental health patients with serious mental illness

Psychosis in behavioral variant frontotemporal dementia

Individual Music Therapy for Mental Health Care Clients with Low Therapy Motivation: Multicentre Randomised Controlled Trial

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