The neglected role of Blastocystis sp. and Giardia lamblia in development of irritable bowel syndrome: A systematic review and meta-analysis

Abedi, Seyed Hasan; Fazlzadeh, Aylar; Mollalo, Abolfazl; Sartip, Behnam; Mahjour, Sanaz; Bahadory, Saeed; Taghipour, Ali; Rostami, Ali

doi:10.1016/j.micpath.2021.105215

Cited by 26 publications

(25 citation statements)

References 82 publications

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“…Some reports show that Blastocystis can colonize human intestines for many years without causing any discomfort [ 12 ], while others suggest that Blastocystis may be a causative agent of intestinal and skin disorders (diarrhea, flatulence, abdominal pain, urticaria) of varying severity and recurrence rates [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The interaction between Blastocystis and irritable bowel syndrome (IBS) is also a subject of ongoing debate [ 22 ]. Although Blastocystis isolated from humans and animals are morphologically indistinguishable, in fact, both human and animal isolates show high genetic variability [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Rare Occurrence of Blastocystis in Pet Animals and Their Owners in the Pomeranian Voivodeship in Poland in the Light of Literature Data

Rudzińska

Kowalewska

Kurpas

et al. 2022

JCM

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Blastocystis is an intestinal microeukaryote with ambiguous pathogenicity, commonly detected in human feces worldwide. It comprises at least 28 genetically diverse subtypes (STs), 12 of which also occur in a wide range of animal species, giving rise to suspicion of zoonotic transmission. To investigate this, we conducted a molecular study of 145 stool samples of pet animals, and 67 of their owners, living in an urban area in Poland. Blastocystis was detected in only three (2.1%) animal samples (of two bearded agamas and a leopard gecko), while all dogs, cats, and pet rodents were Blastocystis-negative. Blastocystis was also present in three (4.5%) owners of animals, but they were cat owners, not reptile owners, and the subtypes identified in them differed significantly from those of reptiles. Additionally, the frequency of Blastocystis in different groups of dogs (depending on how they were kept) was analyzed. This work is the first to find Blastocystis in pet reptiles, and we encourage further investigation of Blastocystis in this poorly examined group of animals, as well as continued study on the transmission of this microorganism between humans and animals.

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Section: Introductionmentioning

confidence: 99%

Rare Occurrence of Blastocystis in Pet Animals and Their Owners in the Pomeranian Voivodeship in Poland in the Light of Literature Data

Rudzińska

Kowalewska

Kurpas

et al. 2022

JCM

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“…Also, the role of Blastocystis in causing inflammatory bowel disease and variations in the intestinal microbial flora is proposed [ 23 ]. In recent years, a relatively high prevalence of Giardia and Blastocystis infection has been reported in people with various disorders, including IBS [ 24 , 25 ]. High prevalence of these two protozoan infections among intellectually disabled individuals in the current study might be linked to the IBS disorder.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Parasitic Infections among Intellectually Disabled Individuals in Bandar Abbas County, Southern Iran

Pakmehr

Omidian

Turki

et al. 2022

Journal of Parasitology Research

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Intellectually disabled individuals are more prone to parasitic infections due to their unusual behaviors, immune and nutrient deficiencies, and living conditions. The current study is aimed at evaluating the prevalence of intestinal parasites in institutionalized intellectually disabled individuals in Bandar Abbas County in the south of Iran. Subjects of the study were 119 individuals, living in an intellectually disabled individual care center. Demographic features of the subjects including age, sex, intellectual disability type, and duration of their stay in the center were recorded. A stool sample was taken from each subject and evaluated by direct wet mount and formalin-ethyl-acetate concentration methods. Samples were also examined, using trichrome and modified acid-fast permanent staining. The mean age of the subjects was 27.6 (±2.24), ranging from 4 to 60 years old. Of the 119 participants, 55 (46.2%) were male, and 64 cases (53.8%) were female. Overall, 31 individuals (26.1%, 95% CI: 18.4-34.9) were found to be infected with at least one type of intestinal parasite. Blastocystis hominis, as the most common detected parasite, was detected in 13 (10.1%), Entamoeba coli in 12 (10.1%), Giardia lamblia in 5 (4.2%), Cryptosporidium in 2 (1.7%), Iodamoeba butchlii in 2 (1.7%), and Endolimax nana in 1 (0.8%) of participants. Three cases had coinfection with Blastocystis hominis and Entamoeba coli, one case was infected with Blastocystis hominis and Giardia lamblia, and one case was coinfected with Giardia lamblia and Entamoeba coli. There were no statistically significant associations between intestinal parasitic infection and gender, age, type of intellectual disability, or duration of stay in the care center ( P > 0.05 ). The findings of the present study indicate a relatively high prevalence of parasitic infections in people with intellectual disabilities in Bandar Abbas, southern Iran. Noteworthy is the high prevalence of Blastocyst and also the presence of Cryptosporidium infection in these people. Periodic treatment of these people and improvement of their maintenance conditions can be considered for the prevention and control of intestinal parasitic infection in these people.

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“…Dientamoeba fragilis is an intestinal protozoan, which, together with Blastocystis sp., are the most prevalent protozoa reported in patients with IBS ( 24 – 26 ). The probable correlation between D. fragilis and IBS was first reported by Borody et al ( 27 ) who showed that eradication of the protozoan led to amelioration of IBS-like symptoms.…”

Section: Parasites and Ibsmentioning

confidence: 99%

Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role of Blastocystis sp.

et al. 2022

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Irritable bowel syndrome (IBS) is a chronic disorder, which its causative agent is not completely clear; however, the interaction between microorganisms and gastrointestinal (GI) epithelial cells plays a critical role in the development of IBS and presenting symptoms. During recent decades, many studies have highlighted the high prevalence of Blastocystis sp. in patients with IBS and suggested a probable role for this protist in this disease. Recent studies have documented changes in the gut microbiota composition in patients with IBS regarding the presence of Blastocystis sp., but it is not clear that either disturbance of the gut during GI disorders is a favorable condition for Blastocystis sp. colonization or the presence of this protist may lead to alteration in the gut microbiota in IBS patients. In this review, we comprehensively gather and discuss scientific findings covering the role of Blastocystis sp. in IBS via gut microbiota shifting.

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The neglected role of Blastocystis sp. and Giardia lamblia in development of irritable bowel syndrome: A systematic review and meta-analysis

Cited by 26 publications

References 82 publications

Rare Occurrence of Blastocystis in Pet Animals and Their Owners in the Pomeranian Voivodeship in Poland in the Light of Literature Data

Rare Occurrence of Blastocystis in Pet Animals and Their Owners in the Pomeranian Voivodeship in Poland in the Light of Literature Data

Intestinal Parasitic Infections among Intellectually Disabled Individuals in Bandar Abbas County, Southern Iran

Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role of Blastocystis sp.

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