The NEK family of serine/threonine kinases as a biomarker for cancer

Panchal, Nagesh Kishan; Sabina, Evan Prince

doi:10.1007/s10238-021-00782-0

Cited by 26 publications

(27 citation statements)

References 76 publications

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“…Therefore, NEK6 has potential diagnostic value for HNSCC. Previews researches showed in liver cancer, breast cancer and gastric cancer the high expression of NEK6 is associated with poor prognosis of patients ( 6 , 11 , 17 , 18 ). Combined with previous studies and our findings, we speculate that high expression of NEK6 may predict poor prognosis in HNSCC patients in the real world.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that cell cycle-related proteins promote tumor cell proliferation by regulating cell mitosis and promote invasion and therapy resistance (5). NEK6 (Never In Mitosis A (NIMA) related kinases 6), a cyclin, promotes the invasion and metastasis of various cancers by regulating cell proliferation and apoptosis (6). NEK6 is highly expressed in colorectal cancer, breast cancer, gastric cancer, prostate cancer, liver cancer, ovarian cancer, and thyroid cancer (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…NEK6 (Never In Mitosis A (NIMA) related kinases 6), a cyclin, promotes the invasion and metastasis of various cancers by regulating cell proliferation and apoptosis (6). NEK6 is highly expressed in colorectal cancer, breast cancer, gastric cancer, prostate cancer, liver cancer, ovarian cancer, and thyroid cancer (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma

et al. 2022

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Head and neck squamous cell carcinoma (HNSCC), as one of the common malignant tumors, seriously threatens human health. NEK6 (Never in Mitosis A (NIMA) related kinases 6), as a cyclin, promotes cancer cell proliferation and cancer progression. However, the prognostic value of NEK6 and its correlation with immune cell infiltration in HNSCC remain unclear. In this study, we comprehensively elucidated the prognostic role and potential function of NEK6 expression in HNSCC. The expression of NEK6 was significantly up-regulated by immunohistochemistry in HNSCC. Upregulation of NEK6 expression in gene expression studies predicts poor prognosis in HNSCC patients. The results of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene set variation analysis indicated that NEK6 is mainly involved in extracellular matrix metabolism and EMT processes. The expression of NEK6 increased with the level of immune cell infiltration and the expression of various immune checkpoints. In conclusion, NEK6 may serve as a candidate prognostic predictor and may predict the response of HNSCC patients to immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma

et al. 2022

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“…Nek2 can regulate the ERK/MAPK pathway, thus promoting the proliferation of gastric cancer cells and the development of gastric cancer. In addition, some scholars pointed out that Nek2 and Nek9 jointly promote the development of tumor diseases, but the mechanism of action of Nek9 in breast cancer is not clear yet [13]. In this study, Nek9 is highly expressed in breast cancer patients and is closely related to breast cancer development, lymphatic metastasis, and TNM staging, suggesting that Nek9, as an essential substance for cell mitosis and maintenance of normal proliferation, can be activated and phosphorylated in cell mitosis to combine with Nek6 and 7 [14].…”

Section: Related Workmentioning

confidence: 99%

Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q‐PCR Technology and Its Relationship with the Disease

Zhu

Huanyu

Zhao

et al. 2022

Contrast Media & Molecular Imaging

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To reveal the relationship between the expression and disease progression, the expression of long noncoding RNA ATB (lncRNA ATB) and related protein kinase 9 (Nek 9) in serum of breast cancer patients by real-time fluorescence quantitative PCR (Q-PCR) is analyzed. The patients treated in our hospital from April 2021 to February 2022 are selected and grouped into several groups. Among them, 73 patients diagnosed with breast cancer and 44 patients with benign breast disease are divided into groups A and B, respectively. In addition, 50 healthy subjects are chosen for group C. The expressions of lncRNA ATB and Nek9 in serum of patients are detected by Q-PCR, and the relationship between different pathological parameters and lncRNA ATB and Nek9 in group A is analyzed. Spearman correlation coefficient is used to evaluate the correlation between lncRNA ATB and Nek9 and disease. The experimental results show that lncRNA ATB and Nek9 in 3 groups are significantly different, and group A> group B> group C (all P < 0.05 ). The expression of lncRNA ATB and Nek9 is closely associated with lymph node metastasis and TNM stage in breast cancer patients P < 0.05 . Besides, the Spearman correlation coefficient shows that lncRNA ATB and Nek9 are positively correlated with breast cancer incidence P < 0.05 . It is evident that lncRNA ATB and Nek9 are expressed at high levels in breast cancer patients and are positively correlated with the occurrence and development of the disease.

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“…The functions of NEK9 in the spindle assembly and centrosome separation ( Kaneta and Ullrich, 2013 ) are essential in the regulation of mitosis. Dysfunction of NEK9 leads to multiple system impairments, including ocular, skeletal, and central nervous system anomalies and various tumors ( Sheppard et al, 2020 ; Panchal and Evan Prince, 2022 ). Pathogenic variants in NEK9 were identified in the fetus with lethal congenital contracture syndrome 10 (OMIM: 617022) and in children with arthrogryposis, Perthes disease, and upward gaze palsy (APUG and OMIM: 614262).…”

Section: Introductionmentioning

confidence: 99%

Novel variants of NEK9 associated with neonatal arthrogryposis: Two case reports and a literature review

Liu

Dai²,

Li³

et al. 2023

Front. Genet.

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Objective: Pathogenic variants in NEK9 (MIM: 609798) have been identified in patients with lethal congenital contracture syndrome 10 (OMIM: 617022) and arthrogryposis, Perthes disease, and upward gaze palsy (APUG and OMIM: 614262). The shared core phenotype is multiple joint contractures or arthrogryposis. In the present study, three novel variants of NEK9 associated with neonatal arthrogryposis were reported.Methods: The clinical data of two premature infants and their parents were collected. The genomic DNA was extracted from their peripheral blood samples and subjected to trio-whole-exome sequencing (trio-WES) and copy number variation analysis.Results: Using trio-WES, a total of three novel pathogenic variants of NEK9 were detected in the two families. Patient 1 carried compound heterozygous variations of c.717C > A (p. C239*741) and c.2824delA (p.M942Cfs*21), which were inherited from his father and mother, respectively. Patient 2 also carried compound heterozygous variations of c.61G > T (p. E21*959) and c. 2824delA (p. M942Cfs*21), which were inherited from his father and mother, respectively. These variants have not been previously reported in the ClinVar, HGMD, or gnomAD databases.Conclusion: This is the first report about NEK9-related arthrogryposis in neonatal patients. The findings from this study suggest that different types of mutations in NEK9 lead to different phenotypes. Our study expanded the clinical phenotype spectrum and gene spectrum of NEK9-associated arthrogryposis.

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The NEK family of serine/threonine kinases as a biomarker for cancer

Cited by 26 publications

References 76 publications

Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma

Predictive Role of NEK6 in Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma

Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q‐PCR Technology and Its Relationship with the Disease

Novel variants of NEK9 associated with neonatal arthrogryposis: Two case reports and a literature review

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