The Nervous System as a Critical Regulator of Immune Responses Underlying Allergy

Forsythe, Paul

doi:10.2174/138161212800165951

Cited by 15 publications

(10 citation statements)

References 206 publications

(275 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the MPTP-mouse model of Parkinsonism [24,25], it was observed the milmed-physical exercise combination restored repeatedly both functional motor activity and dopamine concentrations, as well as increasing markedly the levels of brain-derived neurotrophic factor (BDNF) in motor cortex regions. The antiinflammatory effects of probiotic therapies have been documented [32,33]. Under laboratory conditions, as opposed to providing sufferers with the probiotic compound to-be-ingested in the home environment, both immunologically stabilizing and anti-allergy alleviation was observed [34,35].…”

Section: (Iii)mentioning

confidence: 99%

Milmed Treatment Alleviates Symptoms of Allergy and Improves General Health

Archer¹

2021

J Immuno Allerg

View full text Add to dashboard Cite

The effects of the patented treated-yeast, Saccharomyces cerevisiae, a probiotic suspension which was shown earlier to present neuroprotective and neurorestorative properties, upon allergies presented by a group (n=8) of patients, that were compared with a matched group of patients administered untreated yeast cells (n=8). Treated yeast cells were subjected to millimeter-wave exposure as outlined in patented documents. The patients who administered themselves treated Milmed, over periods extending from four-to-thirteen weeks, completed subjective self-report ratings of their allergy symptoms that indicated marked ameliorative effects; additionally, they rated their general health situations to be markedly improved. Those patients who had taken the untreated yeast did not report these improvements. Correlational analyses between the number of weeks treated Milmed was taken by patients and (i) alleviation of allergy symptoms, and (ii) improvement in general health status, indicated significant relationships in each case. The significant correlations between symptom improvements and general health status, on one hand, and the number of weeks treated Milmed was ingested imply that complete treatments are required for the optimal therapeutic benefits. As observed previously, 8-to-13-week episodes of treated Milmed self-administration provides a lasting amelioration from allergy symptoms and an improved general health status.

show abstract

Section: (Iii)mentioning

confidence: 99%

Milmed Treatment Alleviates Symptoms of Allergy and Improves General Health

Archer¹

2021

J Immuno Allerg

View full text Add to dashboard Cite

show abstract

“…Among these, NGF‐sequestering antibodies have exhibited the most promise in clinical trials. However, in 2012 the US Food and Drug Administration placed a hold on all clinical trials involving anti‐NGF antibodies due to adverse changes in the sympathetic nervous system of mature animals including Pfizer's Tanezumab, a humanized monoclonal antibody that prevents NGF binding to both TrkA and P75 LNTR and was more effective than placebo in reducing pain. In 2009 the latter entered a Phase III trial for knee pain due to osteoarthritis; another phase III trial for hip pain in osteoarthritis was halted in June 2010 when some patients required hip replacement.…”

Section: Inflammation: Ngf and Mast Cellsmentioning

confidence: 99%

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

2017

View full text Add to dashboard Cite

Summary Neurotrophic factors comprise a broad family of biomolecules – most of which are peptides or small proteins – that support the growth, survival and differentiation of both developing and mature neurons. The prototypical example and best‐characterized neurotrophic factor is nerve growth factor (NGF), which is widely recognized as a target‐derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurons and basal forebrain cholinergic nuclei during development and maturation. In addition to being active in a wide array of non‐nervous system cells, NGF is also synthesized by a range of cell types not considered as classical targets for innervation by NGF‐dependent neurons; these include cells of the immune‐haematopoietic lineage and populations in the brain involved in neuroendocrine functions. NGF concentrations are elevated in numerous inflammatory and autoimmune states such as multiple sclerosis, chronic arthritis, systemic lupus erythematosus and mastocytosis, in conjunction with increased accumulation of mast cells. Intriguingly, NGF seems to be linked also with diabetic pathology and insulin homeostasis. Mast cells and NGF appear involved in neuroimmune interactions and tissue inflammation. As mast cells are capable of producing and responding to NGF, this suggests that alterations in mast cell behaviour could provoke maladaptive neuroimmune tissue responses, including those of an autoimmune nature. Moreover, NGF exerts a modulatory role on sensory nociceptive nerve physiology in the adult, which appears to correlate with hyperalgesic phenomena occurring in tissue inflammation. NGF can therefore be viewed as a multifactorial modulator of neuro–immune–endocrine functions.

show abstract

“…The nervous and immune systems have been found to interact closely in host defense and stress responses 17 . Although the relationship of the hypothalamus-pituitary-adrenal (HPA) axis and cortisol has been well studied 18,19 , the natural role of the sympathetic nervous system in regulating immune responses is not fully understood 20,21 . Sympathetic and parasympathetic nerves are found innervating immune organs and near immune cells throughout the body.…”

Section: Introductionmentioning

confidence: 99%

Manipulating Stress Receptor Signaling to Enhance Immunosuppression and Prolong Survival of Vascularized Composite Tissue

Kim¹,

Fisher²,

Bogner³

et al. 2021

Preprint

View full text Add to dashboard Cite

Vascularized composite tissue allotransplantation (VCA) can replace severely damaged body parts but the unavoidable toxicity of high doses of immunosuppressive drugs, such as tacrolimus, required results in significant morbidity. Here we tested whether we could suppress immune activity in a mouse model of VCA by mimicking the natural immune suppression generated by nervous system-induced signaling of adrenergic receptors (AR) by using a safe and well-studied β-AR agonist (terbutaline). Using wild-type and β2-AR-knockout (KO) mice, we found that increased β2-AR signaling results in delayed rejection in VCA recipients, even with subtherapeutic doses of tacrolimus, and this was associated with changes in immune contexture, expression of pro-inflammatory cytokines and chemokines, and function of endothelial adhesion molecules. We propose that β-AR agonists can be used safely to mimic the natural suppression of immune responses generated by adrenergic stress signaling and thereby reduce the dose needed of other more toxic immunosuppressive drugs.

show abstract

The Nervous System as a Critical Regulator of Immune Responses Underlying Allergy

Cited by 15 publications

References 206 publications

Milmed Treatment Alleviates Symptoms of Allergy and Improves General Health

Milmed Treatment Alleviates Symptoms of Allergy and Improves General Health

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

Manipulating Stress Receptor Signaling to Enhance Immunosuppression and Prolong Survival of Vascularized Composite Tissue

Contact Info

Product

Resources

About