The neural correlates of cognitive behavioral therapy: Recent progress in the investigation of patients with panic disorder

Yang, Yunbo; Kircher, Tilo; Straube, Benjamin

doi:10.1016/j.brat.2014.07.011

Cited by 27 publications

(20 citation statements)

References 65 publications

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“…Viele dieser Studien sind innerhalb der großen Multizenterstudie Panik-Netz durchgeführt worden [43]. Veränderungen regionaler Aktivierungen und Konnektivitätsmuster in Verbindung mit Psychotherapieeffekten werden für Amygdala, Mittelhirn, Hippocampus, ACC und frontale Regionen beschrieben, was weitgehend mit dem beschriebenen Furchtnetzwerk überlappt (für Effekte einer psychodynamischen Therapie [44], für Effekte in einem Konditionierungsparadigma [33,45]; für eine Übersicht [46].…”

Section: Therapiestudienunclassified

Angst und Panik

Feldker¹,

Notzon²

2019

Nervenheilkunde

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ZUSAMMENFASSUNGGegenstand und Ziel: Die Forschung zu den neuronalen Korrelaten von Angst und Panik hat sich im letzten Jahrzehnt weiterentwickelt. Seit 1989 Gormans Hypothese zur Neuroanatomie der Panikstörung erschien, wurden viele Studien in den Bereichen Bildgebung und Neurochemie durchgeführt.Material und Methoden: Wir geben eine Übersicht über die Datenlage zu funktionellen Netzwerken bei Angst und Panik mit einem Schwerpunkt auf funktionellen Bildgebungsstudien.Ergebnisse: Für das Verständnis der Panikstörung ist von einem komplexen Modell multipler neuronaler Netzwerke mit Beteiligung von weitaus mehr Hirnregionen als zunächst angenommen auszugehen. Ein mögliches erweitertes neuroanatomisches Netzwerkmodell der Panikstörung umfasst den präfrontalen Kortex, den zingulären Kortex, Thalamus, Hypothalamus, Insel, Hirnstamm, Hippocampus, Amygdala und den Bed Nucleus der Stria Terminalis. Neurochemisch ist eine Vielzahl von Neurotransmittern an der Entstehung der Panikstörung beteiligt.Schlussfolgerungen: Für das Verständnis der funktionellen Netzwerke bei Angst und Panik sind interdisziplinäre Forschung sowie eine dimensionale und transdiagnostische Herangehensweise essenziell.

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Section: Therapiestudienunclassified

Angst und Panik

Feldker¹,

Notzon²

2019

Nervenheilkunde

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“…Modulation of brain activity with cognitive behavioral therapy (CBT) has been reported in panic disorder using a variety of neuroscience methods (Kircher et al, 2013;Prasko et al, 2004;Sakai et al, 2006;Seo, Choi, Chung, Rho, & Chae, 2014;Straube, Glauer, Dilger, Mentzel, Miltner, 2006;Mansson et al, 2016-for a review of studies completed through 2014 see Yang, Kircher, & Straube 2014). Three studies using resting state paradigms found converging evidence that CBT modulates brain activity in frontal regions in individuals with panic disorder (Prasko et al, 2004;Sakai et al, 2006;Seo et al, 2014).…”

Section: Anxiety Disordersmentioning

confidence: 99%

Using neuroscience as an outcome measure for behavioral interventions in Autism spectrum disorders (ASD): A review

Stavropoulos

2017

Research in Autism Spectrum Disorders

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A B S T R A C TThough medications have proven effective in improving associated symptoms of autism spectrum disorder (ASD), behavioral interventions remain the most effective method of improving core symptoms (e.g. social communication, restricted and repetitive behaviors) in this population. Although the cause remains unknown, research provides evidence that ASD is a neurologically based disorder, with differences in brain activity contributing to observed social difficulties. Given the above, along with recent publications underscoring the importance of utilizing neuroscience to measure changes associated with intervention in ASD, it is surprising that studies that measure neurological changes in response to behavioral interventions remain quite rare. Using systematic searches of the PsychINFO and MEDLINE databases, the current review summarizes the extant literature on neural changes in response to behavioral interventions in ASD, and compares the state of the literature in ASD with other disorders such as anxiety, depression, and schizophrenia. We conclude that research utilizing neuroscience to measure changes in response to behavioral interventions in ASD is lacking, and suggest that future research make integrating these two lines of research a priority.

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“…Of note, research dedicated to unravel the neural mechanisms by which psychotherapy acts on the brain is recently complemented by approaches that are able to predict treatment response using innovative techniques such as multivariate pattern recognition within a machine learning framework [9]. Both directions ultimately aim to increase treatment response, but they differ in the strategy chosen: The mechanistic approach informs neurobiological models of disease and mechanisms of treatment, including component analyses and moderator studies [10] to optimize treatments based on an improved understanding of those brain circuits targeted by psychotherapy [11]. The predictor approach aims to provide prognostic information for the individual patient and to improve response rates by stratifying patients to a particular treatment [12].…”

Section: Introductionmentioning

confidence: 99%

Functional neuroimaging of psychotherapeutic processes in anxiety and depression

Lueken

Hahn

2016

Current Opinion in Psychiatry

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Present findings encourage the search for predictors providing clinically meaningful information for single patients. However, independent validation as a crucial prerequisite for clinical use is still needed. Identifying nonresponders a priori creates the need for alternative treatment options that can be developed based on an improved understanding of those neural mechanisms underlying effective interventions.

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The neural correlates of cognitive behavioral therapy: Recent progress in the investigation of patients with panic disorder

Cited by 27 publications

References 65 publications

Angst und Panik

Angst und Panik

Using neuroscience as an outcome measure for behavioral interventions in Autism spectrum disorders (ASD): A review

Functional neuroimaging of psychotherapeutic processes in anxiety and depression

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