The neural correlates of discrete gait characteristics in ageing: A structured review

Wilson, J.; Allcock, Liesl M.; Ardle, Ríona Mc; Taylor, John‐Paul; Rochester, Lynn

doi:10.1016/j.neubiorev.2018.12.017

Cited by 96 publications

(110 citation statements)

References 88 publications

(557 reference statements)

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Motor control requires proper integration of various inputs and accurate communication between different brain regions, such as the motor cortex, somatosensory cortex, and basal ganglia 27 , 29 . Disrupted white matter integrity could dampen the communication efficiency and result in poor motor performance.…”

Section: Discussionmentioning

confidence: 99%

“…Motor control requires receiving and processing various input information, including visual, proprioceptive, vestibular, and sensorimotor information. To properly integrate these inputs and accurately plan and control the movement, many cortical and subcortical regions interact delicately with each other through white matter networks 2 , 27 – 29 . Damage to white matter tracts possibly impedes communication between these networks, which might result in motor impairment 7 , 8 , 18 , 30 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Disrupted white matter integrity and network connectivity are related to poor motor performance

Zhai

Liu

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Motor impairment is common in the elderly population. Disrupted white matter tracts and the resultant loss of connectivity between cortical regions play an essential role in motor control. Using diffusion tensor imaging (DTI), we investigated the effect of white matter microstructure on upper-extremity and lower-extremity motor function in a community-based sample. A total of 766 participants (57.3 ± 9.2 years) completed the assessment of motor performance, including 3-m walking speed, 5-repeat chair-stand time, 10-repeat hand pronation-supination time, and 10-repeat finger-tapping time. Fractional anisotropy (FA), mean diffusivity (MD), and structural network connectivity parameters were calculated based on DTI. Lower FA and higher MD were associated with poor performance in walking, chair-stand, hand pronation-supination, and finger-tapping tests, independent of the presence of lacunes, white matter hyperintensities volume, and brain atrophy. Reduced network density, network strength, and global efficiency related to slower hand pronation-supination and finger-tapping, but not related to walking speed and chair-stand time. Disrupted white matter integrity and reduced cerebral network connectivity were associated with poor motor performance. Diffusion-based methods provide a more in-depth insight into the neural basis of motor dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Disrupted white matter integrity and network connectivity are related to poor motor performance

Zhai

Liu

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The neural mechanisms associated with age-and disease-related gait changes have been investigated using neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), near-infrared spectroscopy (NIRS) and electroencephalography (EEG). Studies using these imaging techniques have shown that gait-related brain activity differs in older adults and people with PD (Maillet et al 2012, Bohnen & Jahn 2013, Herman et al 2013, Hamacher et al 2015, Stuart et al 2018, Wilson et al 2018. For example, older adults exhibit greater activity in various cortical regions including motor, somatosensory, visual and frontal cortices than young individuals during gait imagery as revealed by fMRI (Wai et al 2012, Zwergal et al 2012, Allali et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Corticomuscular control of walking in older people and people with Parkinson’s disease

Roeder

Boonstra

Kerr

2019

Preprint

View full text Add to dashboard Cite

Changes in human gait that result from ageing or neurodegenerative diseases are multifactorial. Here we assess the effects of age and Parkinson’s disease (PD) on corticospinal control in electrophysiological activity recorded during treadmill and overground walking. Electroencephalography (EEG) from 10 electrodes and electromyography (EMG) from two leg muscles were acquired from 22 healthy young, 24 healthy older and 20 adults with PD. Event-related power, corticomuscular coherence (CMC) and inter-trial coherence were assessed for EEG from bilateral sensorimotor cortices and EMG from tibialis anterior muscles during the double support phase of the gait cycle. CMC and EMG power in the low beta band (13-21 Hz) was significantly decreased in older and PD participants compared to young people, but there was no difference between older and PD groups. Older and PD participants spent shorter time in the swing phase than young individuals. These findings indicate age-related changes in the temporal coordination of gait. The decrease in beta CMC suggests reduced cortical input to spinal motor neurons in older people during the double support phase. We also observed multiple changes in electrophysiological measures at high beta and low gamma frequencies during treadmill compared to overground walking, indicating task-dependent differences in corticospinal locomotor control.

show abstract

“…Emerging evidence shows that a decline in gait speed can predict cognitive decline by more than a decade (Verghese et al, 2013;Kikkert et al, 2016;Dumurgier et al, 2017;Montero-Odasso et al, 2018). The brain areas for gait control involve regions responsible for attentional, executive, and visuospatial functions as well as the cerebellum, basal ganglia, and motor cortex (Verghese et al, 2013;Holtzer et al, 2014;Kikkert et al, 2016;Demnitz et al, 2017;Wilson et al, 2019). Evidence is accumulating that proves there is an overlap between brain areas related to cognitive and gait decline (Verghese et al, 2013;Kikkert et al, 2016;Wilson et al, 2019).…”

Section: Age-related Relationship Between Gait and Cognitionmentioning

confidence: 99%

“…The brain areas for gait control involve regions responsible for attentional, executive, and visuospatial functions as well as the cerebellum, basal ganglia, and motor cortex (Verghese et al, 2013;Holtzer et al, 2014;Kikkert et al, 2016;Demnitz et al, 2017;Wilson et al, 2019). Evidence is accumulating that proves there is an overlap between brain areas related to cognitive and gait decline (Verghese et al, 2013;Kikkert et al, 2016;Wilson et al, 2019). One of the important questions at present, originates from the complexity of cognition.…”

Section: Age-related Relationship Between Gait and Cognitionmentioning

confidence: 99%

Mobility in Older Community-Dwelling Persons: A Narrative Review

2020

View full text Add to dashboard Cite

Due to the demographic changes and the increasing awareness of the role of physical function, mobility in older age is becoming an important topic. Mobility limitations have been reported as increasingly prevalent in older persons affecting about 35% of persons aged 70 and the majority of persons over 85 years. Mobility limitations have been associated with increased fall risk, hospitalization, a decreased quality of life, and even mortality. As concepts of mobility are multifactorial and complex, in this narrative review, definitions, physical factors, and their age-related changes associated with mobility will be presented. Also, areas of cognitive decline and their impact on mobility, as well as neuromuscular factors related to mobility will be addressed. Another section will relate psychological factors such as Fall-related psychological concerns and sedentary behavior to mobility. Assessment of mobility as well as effective exercise interventions are only shortly addressed. In the last part, gaps and future work on mobility in older persons are discussed.

show abstract

The neural correlates of discrete gait characteristics in ageing: A structured review

Cited by 96 publications

References 88 publications

Disrupted white matter integrity and network connectivity are related to poor motor performance

Disrupted white matter integrity and network connectivity are related to poor motor performance

Corticomuscular control of walking in older people and people with Parkinson’s disease

Mobility in Older Community-Dwelling Persons: A Narrative Review

Contact Info

Product

Resources

About