The neural correlates of verbal encoding and retrieval in monozygotic twins at low or high risk for depression and anxiety

Wolfensberger, Saskia P.A.; Veltman, Dick J.; Hoogendijk, Witte J.G.; Ruiter, Michiel B. de; Boomsma, Dorret I.; Geus, Eco J. C. de

doi:10.1016/j.biopsycho.2008.01.002

Cited by 23 publications

(19 citation statements)

References 48 publications

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“…This discovery is in agreement with previous findings about the importance of a family history of depression in diagnosis [1][2][3][4]43 and neuroimaging 6,8,9 of individuals with MDD. As predicted, neural mechanisms of emotion processing and attention shifting from the said processing are affected by the aforementioned modulation.…”

Section: Discussionsupporting

confidence: 93%

“…Such was also the case in previous studies of behavioural and functional correlates of family vulnerability to the disease. 9 With regards to the neural correlates of relative resilience, when compared with the MDD-FHP group, the HC-FHP group displayed greater activation during emotion processing in the visual cortex and the left SuMG, which is involved in associating somatosensory information with verbal categories and lexical knowledge. 59 One can conclude that in the resilient HC-FHP group, greater attention resources are devoted to observing external emotional stimuli than in the MDD-FHP group.…”

Section: Figmentioning

confidence: 96%

“…8 Also, healthy monozygotic twins of patients with MDD showed greater activation in the left infer ior frontal gyrus during verbal encoding and retrieval. 9 These neural differences were discovered in spite of the absence of negative bias on a behavioural level, suggesting that susceptibility and associated changes can manifest themselves without behavioural signals. Also, acute tryptophan depletion triggered depressive moods in relatives of patients with MDD, but not in healthy controls.…”

Section: Introductionmentioning

confidence: 99%

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Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Lisiecka

Carballedo

Fagan

et al. 2013

J Psychiatry Neurosci

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IntroductionIndividuals with a first-degree relative who has major depressive disorder (MDD) are at a 2-to 3-fold greater risk for depression than those without a family history of MDD. 1 Rela tives of depressed patients, compared with individuals without family history of psychiatric disorders, are characterized by elevated neuroticism, depressive cognitions and rigidity 2 and by stability of these traits over time.3 Patients with MDD who had relatives with an affective disorder display greater neuroticism 4 and have an earlier age of onset of MDD. 5 Evidently, family history of MDD alters susceptibility to depression and to an acute MDD episode. The factor is clinically important since it involves mechanisms of elevated risk for MDD (relatives of patients with MDD compared with healthy controls), suggests relative resilience to the disease (relatives of patients with MDD compared with the patients themselves) and points to different endophenotypes of healthy controls and patients with MDD. A good understanding of these mechanisms should not be underestimated if diagnosis, therapy and prevention of the disorder are to be enhanced. Background: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions altered by MDD and family history of the disease; therefore, it is important to recognize the neural correlates of these functions in association with both factors. Methods: Our study determines neural correlates of emotion processing and attention shifting for healthy individuals and patients with MDD with and without family history of depression. We compared the performance and neural activity in a functional magnetic resonance imaging experiment examining emotion processing and attention shifting in all participants. Results: Our sample included 4 study groups: healthy controls without family history of depression (n = 25), patients with MDD without family history of the disease (n = 20), unaffected healthy first-degree relatives of patients with MDD (n = 21) and patients with MDD with family history of MDD (n = 30). Compared with healthy controls, unaffected first-degree relatives overactivate the somatosensory cortex and the attention controlling areas during both emotion processing and attention shifting. Patients with family history of MDD have stronger neural activation in subcortical areas during shifting attention from negative stimuli. Patients without family history of MDD have less activation in the paralimbic regions and more activation in core limbic areas, especially during emotion processing. Limitations: The conclusions about the intergroup differences in activation can be drawn only about neural areas engaged in the task. Conclusion: Unaffected first-degree relatives of patients with MDD overreact to external emotional cues and compensate for the vulnerability with increased involvement of executive control. Patients with a family history of MDD have le...

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Section: Discussionsupporting

confidence: 93%

Section: Figmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Lisiecka

Carballedo

Fagan

et al. 2013

J Psychiatry Neurosci

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“…For example, depressed patients show increased amygdala activity during successful memory formation for faces and negative pictures [Hamilton and Gotlib, 2008;Roberson-Nay et al, 2006]. Furthermore, increased prefrontal activity during verbal emotional memory formation has been observed in individuals at risk for mood disorders, such as anxiety and depression [Wolfensberger et al, 2008]. This suggests that the larger contribution of these brain regions during emotional memory formation in deletion carriers might indicate a marker of vulnerability in the development of mood disorders.…”

Section: Discussionmentioning

confidence: 96%

Genetic variation of the α2b‐adrenoceptor affects neural correlates of successful emotional memory formation

Urner

Wingen

Franke

et al. 2011

Human Brain Mapping

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“…Other research suggests interesting potential neural links to rumination and difficulties with perseverating on negative emotional material (e.g., Berman et al, 2011; Cooney, Joormann, Eugene, Dennis, & Gotlib, 2011; Eugene, Joormann, Cooney, Atlas, & Gotlib, 2009). Last, a handful of other studies have investigated neural activation in relation to depression-related categorization and memory biases (Chan, Harmer, Goodwin, & Norbury, 2008; Ramel et al, 2007; Wolfensberger et al, 2008) as well as selective attention (Mannie et al, 2008). …”

Section: A Multiple Levels Of Analysis Model Integrating Vulnerabilitmentioning

confidence: 99%

Future Directions in Vulnerability to Depression Among Youth: Integrating Risk Factors and Processes Across Multiple Levels of Analysis

Hankin

2012

Journal of Clinical Child & Adolescent Psychology

102

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Depression is a developmental phenomenon. Considerable progress has been made in describing the syndrome, establishing its prevalence and features, providing clues as to its etiology, and developing evidence-based treatment and prevention options. Despite considerable headway in distinct lines of vulnerability research, there is an explanatory gap in the field ability to more comprehensively explain and predict who is likely to become depressed, when, and why. Still, despite clear success in predicting moderate variance for future depression, especially with empirically rigorous methods and designs, the heterogeneous and multi-determined nature of depression suggests that additional etiologies need to be included to advance knowledge on developmental pathways to depression. This paper advocates for a multiple levels of analysis approach to investigating vulnerability to depression across the lifespan and providing a more comprehensive understanding of its etiology. One example of a multiple levels of analysis model of vulnerabilities to depression is provided that integrates the most accessible, observable factors (e.g., cognitive and temperament risks), intermediate processes and endophenotypes (e.g., information processing biases, biological stress physiology, and neural activation and connectivity), and genetic influences (e.g., candidate genes and epigenetics). Evidence for each of these factors as well as their cross-level integration is provided. Methodological and conceptual considerations important for conducting integrative, multiple levels of depression vulnerability research are discussed. Finally, translational implications for how a multiple levels of analysis perspective may confer additional leverage to reduce the global burden of depression and improve care are considered.

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The neural correlates of verbal encoding and retrieval in monozygotic twins at low or high risk for depression and anxiety

Cited by 23 publications

References 48 publications

Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Genetic variation of the α2b‐adrenoceptor affects neural correlates of successful emotional memory formation

Future Directions in Vulnerability to Depression Among Youth: Integrating Risk Factors and Processes Across Multiple Levels of Analysis

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