The neuroactive neurosteroid Dehydroepiandrosterone Sulfate (DHEAS) modulates the serotonergic system within the dorsal Raphe nucleus and the cerebrospinal fluid release of Reissner’s fiber in rat

Hiba, Omar El; Draoui, Ahmed; Gamrani, Halima

doi:10.5802/crbiol.3

Cited by 1 publication

(1 citation statement)

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“…In addition, the SCO is a highly innervated organ, receiving different inputs carrying monoamines, acetylcholine, neuropeptides, and GABA. Some findings suggest that serotonin and other monoamines may modulate SCO secretory activity, perhaps driven by signals generated from the neural tube itself ( Rodríguez et al, 1992 ; Richter et al, 2004 ; El Hiba et al, 2020 ).…”

Section: Hypotheses About Rf’s Functionsmentioning

confidence: 99%

The Enigmatic Reissner’s Fiber and the Origin of Chordates

Aboitiz

Montiel

2021

Front. Neuroanat.

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Reissner’s fiber (RF) is a secreted filament that floats in the neural canal of chordates. Since its discovery in 1860, there has been no agreement on its primary function, and its strong conservation across chordate species has remained a mystery for comparative neuroanatomists. Several findings, including the chemical composition and the phylogenetic history of RF, clinical observations associating RF with the development of the neural canal, and more recent studies suggesting that RF is needed to develop a straight vertebral column, may shed light on the functions of this structure across chordates. In this article, we will briefly review the evidence mentioned above to suggest a role of RF in the origin of fundamental innovations of the chordate body plan, especially the elongation of the neural tube and maintenance of the body axis. We will also mention the relevance of RF for medical conditions like hydrocephalus, scoliosis of the vertebral spine and possibly regeneration of the spinal cord.

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Section: Hypotheses About Rf’s Functionsmentioning

confidence: 99%