The neurobiological correlates of cognitive outcomes in adolescence and adulthood following very preterm birth

Hadaya, Laila; Nosarti, Chiara

doi:10.1016/j.siny.2020.101117

Cited by 18 publications

(9 citation statements)

References 60 publications

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“…Despite this, little is known about the impact of birth weight variation on white matter microstructure in late life. Below the normal range birth weight is linked to a range of neurobiological correlates that extend into adolescence including reduced white matter microstructural integrity, and deviations in cortical thickness (both region dependent thickening and thinning), and volumetric alterations that may be associated with reduced cognitive function ( Bjuland et al, 2013 , De Bie et al, 2011 , Eikenes et al, 2011 , Hadaya and Nosarti, 2020 , Karolis et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

Wheater

Shenkin

Maniega

et al. 2021

NeuroImage: Clinical

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Section: Introductionmentioning

confidence: 99%

Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

Wheater

Shenkin

Maniega

et al. 2021

NeuroImage: Clinical

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“…However, little is known about the impact of birth weight variation on white matter microstructure in later life. Below the normal range birth weight is linked to a range of neurobiological correlates that extend into adolescence including reduced white matter microstructural integrity (19), and deviations in cortical thickness (both region dependent thickening and thinning) (20,21), and volumetric alterations (22) that may be associated with reduced cognitive function (Hadaya and Nosarti, 2020).…”

Section: Introductionmentioning

confidence: 99%

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

Wheater

Shenkin

Maniega

et al. 2020

Preprint

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Birth weight, an indicator of fetal growth, is associated with cognitive outcomes in early life and risk of metabolic and cardiovascular disease across the life course. Cognitive ability in early life is predictive of cognitive ability in later life. Brain health in older age, defined by MRI features, is associated with cognitive performance. However, little is known about how variation in normal birth weight impacts on brain structure in later life. In a community dwelling cohort of participants in their early seventies we tested the hypothesis that birthweight is associated with the following MRI features: total brain (TB), grey matter (GM) and normal appearing white matter (NAWM) volumes; whiter matter hyperintensity (WMH) volume; a general factor of fractional anisotropy (gFA) and peak width skeletonised mean diffusivity (PSMD) across the white matter skeleton. We also investigated the associations of birthweight with cortical surface area, volume and thickness. Birthweight was positively associated with TB, GM and NAWM volumes in later life (β ≥ 0.194), and with regional cortical surface area but not gFA, PSMD, WMH volume, or cortical volume or thickness. These positive relationships appear to be explained by larger intracranial volume rather than by age-related tissue atrophy, and are independent of body height and weight in adulthood. This suggests that larger birthweight is linked to increased brain tissue reserve in older life, rather than a resilience to age-related changes in brain structure, such as tissue atrophy or WMH volume.Significance StatementCognitive brain ageing carries a high personal, societal and financial cost and understanding its developmental origins is important for identifying possible preventative strategies. In a sample of older participants from the Lothian Birth Cohort 1936 we were able to explore the neurobiological correlates of birth weight, which is indicative of the fetal experience. We find that higher birth weight is related to larger brain tissue volumes in later life, but does not modify the trajectory of age-related change. This suggests that early life growth confers preserved differentiation, rather than differential preservation with regards to brain reserve. That these effects are detectable into later life indicates that this variable may be valuable biomarker in the epidemiology of ageing.

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“…VPT birth is associated with widespread alterations in neonatal structural and functional brain development, including decreased global and regional brain volumes, smaller cortical surfaces with less complex gyral and sulcal development, aberrant white matter microstructure, and reduced functional network connectivity ( 4 , 8 ). Neonatal reductions in frontal, temporal, parietal, and occipital brain volumes as well as smaller thalami and amygdala have been linked to neurodevelopmental and socioemotional impairments in VPT children ( 4 , 8 ). However, conventional structural magnetic resonance imaging (MRI) findings have only explained a modest proportion of variance in outcome.…”

mentioning

confidence: 99%

“…Thus, more novel approaches are needed to increase the predictive utility of neonatal structural MRI to identify VPT infants who are at greatest risk of poor outcome. As such, recent investigations have begun to leverage network-based approaches to reveal the neuropathological basis for later cognitive and behavioral impairments ( 4 , 5 , 8 ). Little is known about the ways in which VPT birth disrupts the coordinated growth of spatially distributed sets of brain regions.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Neonatal Brain Structure and Cognitively Stimulating Parenting Differentially Relate to Cognitive and Behavioral Outcomes of Children Born Very Preterm

Lean

Ortinau

2021

Biological Psychiatry Global Open Science

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The neurobiological correlates of cognitive outcomes in adolescence and adulthood following very preterm birth

Cited by 18 publications

References 60 publications

Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

Neonatal Brain Structure and Cognitively Stimulating Parenting Differentially Relate to Cognitive and Behavioral Outcomes of Children Born Very Preterm

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