The neurobiology of schizotypy: Fronto-striatal prediction error signal correlates with delusion-like beliefs in healthy people

Abstract

Healthy people sometimes report experiences and beliefs that are strikingly similar to the symptoms of psychosis in their bizarreness and the apparent lack of evidence supporting them. An important question is whether this represents merely a superficial resemblance or whether there is a genuine and deep similarity indicating, as some have suggested, a continuum between odd but healthy beliefs and the symptoms of psychotic illness. We sought to shed light on this question by determining whether the neural marker for prediction error - previously shown to be altered in early psychosis – is comparably altered in healthy individuals reporting schizotypal experiences and beliefs. We showed that non-clinical schizotypal experiences were significantly correlated with aberrant frontal and striatal prediction error signal. This correlation related to the distress associated with the beliefs. Given our previous observations that patients with first episode psychosis show altered neural responses to prediction error and that this alteration, in turn, relates to the severity of their delusional ideation, our results provide novel evidence in support of the view that schizotypy relates to psychosis at more than just a superficial descriptive level. However, the picture is a complex one in which the experiences, though associated with altered striatal responding, may provoke distress but may nonetheless be explained away, while an additional alteration in frontal cortical responding may allow the beliefs to become more delusion-like: intrusive and distressing.

Varieties of Voice-Hearing: Psychics and the Psychosis Continuum

“…1 The impact of these observations on research practice has been extensive. [2][3][4][5][6][7][9][10][11][12] However, these observations have not yet changed clinical practice. 13 Indeed, some are skeptical whether they even can.…”

Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis

“…Only recently, researchers have begun to shed light on this important question, but data are still very limited. 22,[32][33][34] Importantly, with respect to individuals with schizotypal traits no study has ever investigated reward anticipation to identify neural correlates of symptom expression.…”

Studying Delusions Within Research Domain Criteria: The Challenge of Configural Traits When Building a Mechanistic Foundation for Abnormal Beliefs

“…13 In this sense, the work based on prediction error is worthy of attention but remains incomplete. One important clue, though, may be evidence of concurrent failures in other systems, such as more cognitive frontoparietal networks, 14 where we turn to next. In the context of the day-to-day formation of strong superstitious beliefs, Risen 15 has argued that superstitious beliefs will endure following any failure to (1) detect that a potential error has occurred from emotional reasoning, (2) resolve to reject the resulting emotional-driven belief, or (3) correct the resulting emotional-driven belief.…”