The neurobiology of social play behavior in rats

Vanderschuren, Louk J. M. J.; Niesink, Raymond; Ree, Jan M. van

doi:10.1016/s0149-7634(96)00020-6

Cited by 514 publications

(493 citation statements)

References 234 publications

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“…The frequency of a number of social activities from the ethogram of each test subject was analyzed from the video recordings [36,38]. Overall social activity was scored as the sum of the frequencies of the following social behaviors: social investigation (sniffing of any part of the body of the partner), contact (crawling over and under the partner and social grooming), and play behavior (pouncing or playful nape attack, chasing, and pinning).…”

Section: Behavioral Observationmentioning

confidence: 99%

Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats

Varlinskaya

Spear

2007

Neurotoxicology and Teratology

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Section: Behavioral Observationmentioning

confidence: 99%

Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats

Varlinskaya

Spear

2007

Neurotoxicology and Teratology

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“…Single housing may influence animals' behavior (Douglas et al, 2003;Vanderschuren et al, 1997), however, it allowed for accurate measurement of fluid intake/nicotine consumption for each animal. Animals were exposed to nicotine and/or ethanol from PN30 to PN45, the approximate age range during which animals of both genders and most breeding stock exhibit adolescent-typical behavioral characteristics and particular neurochemical and endocrine patterns when compared to adulthood and prepubertal periods (Spear, 2000).…”

Section: Animal Treatment and Behavioral Testingmentioning

confidence: 99%

Combined Exposure to Nicotine and Ethanol in Adolescent Mice Differentially Affects Anxiety Levels during Exposure, Short-Term, and Long-Term Withdrawal

Abreu‐Villaça

Nunes

Queiroz-Gomes

et al. 2007

Neuropsychopharmacol

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Smoking and consumption of alcoholic beverages are frequently associated during adolescence. This association could be explained by the cumulative behavioral effects of nicotine and ethanol, particularly those related to anxiety levels. However, despite epidemiological findings, there have been few animal studies of the basic neurobiology of the combined exposure in the adolescent brain. In the present work we assessed, through the use of the elevated plus maze, the short-and long-term anxiety effects of nicotine (NIC) and/or ethanol (ETOH) exposure during adolescence (from the 30th to the 45th postnatal day) in four groups of male and female C57BL/6 mice: (1) Concomitant NIC (nicotine free-base solution (50 mg/ml) in 2% saccharin to drink) and ETOH (ethanol solution (25%, 2 g/kg) i.p. injected every other day) exposure; (2) NIC exposure; (3) ETOH exposure; (4) Vehicle. C57BL/6 mice were selected, in spite of the fact that they present slower ethanol metabolism, because they readily consume nicotine in the concentration used in the present study. During exposure (45th postnatal day: PN45), our results indicated that ethanol was anxiolytic in adolescent mice and that nicotine reverted this effect. Short-term drug withdrawal (PN50) elicited sex-dependent effects: exposure to nicotine and/or ethanol was anxiogenic only for females. Although neither nicotine nor ethanol effects persisted up to 1 month postexposure (PN75), the coadministration elicited an anxiogenic response. In spite of the fact that generalizations based on the results from a single strain of mice are prone to shortcomings, our results suggest that the deficient response to the anxiolytic effects of ethanol in adolescents co-exposed to nicotine may drive higher ethanol consumption. Additionally, increased anxiety during long-term smoking and drinking withdrawal may facilitate relapse to drug use.

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Section: Introductionmentioning

confidence: 99%

“…Thus, social play is considered the most characteristic expression of social activity in adolescent animals (Panksepp et al, 1984;Vanderschuren et al, 1997;Pellis and Pellis., 1998). Social play is rewarding for adolescent rats (Calcagnetti and Schechter, 1992;Humphreys and Einon, 1981;Normansell and Panksepp, 1990;van den Berg et al, 1999b) and it is modulated by neural systems involved in reward and motivation, such as the opioid and dopaminergic systems (Vanderschuren et al, 1997;Siviy, 1998). Thus, treatment with morphine enhances (Niesink and Van Ree, 1989;Panksepp et al, 1985;Vanderschuren et al, 1995a) and treatment with opioid antagonists decreases social play behavior (Beatty and Costello, 1982;Panksepp et al, 1985;Siegel and Jensen, 1986;Siegel et al, 1985;Vanderschuren et al, 1995c).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, treatment with morphine enhances (Niesink and Van Ree, 1989;Panksepp et al, 1985;Vanderschuren et al, 1995a) and treatment with opioid antagonists decreases social play behavior (Beatty and Costello, 1982;Panksepp et al, 1985;Siegel and Jensen, 1986;Siegel et al, 1985;Vanderschuren et al, 1995c). The role of dopaminergic neurotransmission in the modulation of social play is less clear, as both increases and decreases in social play behavior have been reported after treatment with dopamine receptor agonists (Niesink and Van Ree, 1989;Siviy et al, 1996;Vanderschuren et al, 1997Vanderschuren et al, , -2008Siviy, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

Trezza¹,

Vanderschuren²

2008

European Neuropsychopharmacology

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We have recently shown that the pharmacological mechanisms through which cannabinoid and opioid drugs influence social play behavior in adolescent rats can be partially dissociated. Here, we characterize the effects of the direct cannabinoid agonist WIN55,212-2, the indirect cannabinoid agonist URB597 and the opioid agonist morphine on social play at the behavioral level. By treating either one or both partners of the test dyad, we show that these drugs differentially affect play solicitation and play responsiveness. By testing these drugs in animals which were either familiar or unfamiliar to the test cage, we show that environmental factors differentially modulate the effects of cannabinoid and opioid drugs on social play. These results support and extend our previous findings suggesting that, although cannabinoid and opioid systems interact in the modulation of social play behavior in adolescent rats, they do so through partially dissociable behavioral and pharmacological mechanisms.

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The neurobiology of social play behavior in rats

Cited by 514 publications

References 234 publications

Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats

Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats

Combined Exposure to Nicotine and Ethanol in Adolescent Mice Differentially Affects Anxiety Levels during Exposure, Short-Term, and Long-Term Withdrawal

Cannabinoid and opioid modulation of social play behavior in adolescent rats: Differential behavioral mechanisms

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