Abstract:Targeted muscle reinnervation (TMR) is a peripheral nerve procedure that can prevent and treat postamputation pain. The nerve transfer allows for organized nerve regeneration and repair after amputation surgery. The procedure can successfully prevent neuromas despite large size mismatches between the donor and recipient nerves. Here, we discuss the fundamentals of peripheral nerve injury and regeneration as it pertains to TMR. We propose axonal pruning to explain axon behavior when there are large size mismatc… Show more
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