The neurochemical consequences of methamphetamine self-administration in male and female rats

Johansen, Andrew; McFadden, Lisa M.

doi:10.1016/j.drugalcdep.2017.04.011

Cited by 23 publications

(13 citation statements)

References 31 publications

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“…Here, we used a METH SA protocol in which rats were given access to the drug for 6 h over 14 consecutive days. We do not report sex differences in drug intake, which is consistent with other studies using similar protocols (Johansen and McFadden, 2017; Venniro et al, 2017). However, female rats appear to take more drug on the first day of SA.…”

Section: Discussionsupporting

confidence: 92%

Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex

Pena-Bravo

Penrod

Reichel

et al. 2019

eNeuro

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Preclinical and clinical research has shown that females are more vulnerable to the rewarding effects of stimulants, and it has been proposed that estrogens may play a role in this enhanced sensitivity; however sex differences in methamphetamine (METH)-induced neuroplasticity have not been explored. To address this gap in knowledge, we recorded from the prelimbic area of the prefrontal cortex (PL-PFC) of male and female rats following long access METH self-administration (SA) and investigated the resulting long-term synaptic neuroadaptations. Males and females took similar amounts of METH during SA; however, female rats exhibit significant synaptic baseline differences when compared to males. Furthermore, females exhibited a significant increase in evoked excitatory currents. This increase in evoked glutamate was correlated with increases in NMDA currents and was not affected by application of a GluN2B selective blocker. We propose that METH SA selectively upregulates GluN2B-lacking NMDA receptors (NMDAR) in the PFC of female rats. Our results may provide a mechanistic explanation for the sex differences reported for METH addiction in females.

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Section: Discussionsupporting

confidence: 92%

Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex

Pena-Bravo

Penrod

Reichel

et al. 2019

eNeuro

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“…No sex differences were observed in METH intake [Behavioral No Extinction: F(1,72)=0.79, ns; Behavioral Extinction: F(1,72)=0.03, ns] nor did sex interact with day [Behavioral No Extinction: F(6,72)=0.26, ns; Behavioral Extinction: F(6,72)=0.16, ns]. Self-administration for the autoradiography findings has been previously published (see Figure 1 of Johansen et al, 2017 ) but followed a similar pattern.…”

Section: Resultsmentioning

confidence: 80%

“…Food training, self-administration, and extinction training occurred in an operant chamber (Coulbourn Instruments) as described previously ( Johansen et al, 2017 ). Prior to catheter surgery rats received 4 (14 h/night) food training sessions during which pressing the active lever resulted in a 45-mg food pellet.…”

Section: Methodsmentioning

confidence: 99%

Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration

McFadden

Cordie

Livermont

et al. 2018

International Journal of Neuropsychopharmacology

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BackgroundMethamphetamine use is associated with a variety of negative health outcomes, including psychosis. The frontal cortex serotonin receptors are thought to contribute to psychosis-like behaviors. This study investigated changes in serotonergic markers in the frontal cortex following methamphetamine self-administration and hallucinogenic drug-induced behavior.MethodsConsistent with previously published studies, freely cycling male and female rats were allowed to self-administer methamphetamine (males: 0.12 mg/infusion; females: 0.09 mg/infusion) or saline (10 µL) for 7 days. On the day following self-administration or following 10 days of extinction training, animals were given the serotonin 2A/2C agonist, 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (2 mg/kg, i.p.), and head twitches were analyzed. Autoradiography was also used to assess serotonin receptors and transporters in the frontal cortex following self-administration.ResultsMethamphetamine self-administration led to an increase in DOI-induced head-twitch behavior compared to saline only on the day following self-administration. Increases in serotonin receptors in the orbitofrontal cortex and decreases in serotonin transporters in the orbitofrontal cortex and infralimbic cortex were observed following methamphetamine self-administration as assessed by autoradiography.ConclusionsMethamphetamine self-administration was associated with serotonergic alterations in the frontal cortex, which may underlie behavioral changes related to methamphetamine-associated psychosis.

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“…In addition, a previous study reported that female rats displayed greater and longer‐lasting locomotor activity and more stereotypic behaviors in amphetamine and METH exposed rats 82 . However, other study has showed that male and female rats had similar METH intake using self‐administration 83 . Future studies are needed to confirm the sex differences in 3‐FMA abuse.…”

Section: Discussionmentioning

confidence: 88%

“…82 However, other study has showed that male and female rats had similar METH intake using selfadministration. 83 Future studies are needed to confirm the sex differences in 3-FMA abuse.…”

Section: Primed Reinstatement Of 3-fma Reinforcementmentioning

confidence: 99%

The potent psychomotor, rewarding and reinforcing properties of 3‐fluoromethamphetamine in rodents

et al. 2019

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3-fluoromethamphetamine (3-FMA), a derivative of methamphetamine (METH), produces behavioral impairment and deficits in dopaminergic transmission in the striatum of mice. The abuse potential of 3-FMA has not been fully characterized. The aim of this study was to evaluate the effects of 3-FMA on locomotor activity as well as its rewarding and reinforcing properties in the conditioned place preference (CPP) and self-administration procedures. Intravenous (i.v.) administration of 3-FMA (0.5 and 1.0 mg/kg) significantly increased locomotor activity in a dose-dependent manner in rats. In the CPP procedure, intraperitoneal administration of 3-FMA (10 and 30 mg/kg) produced a significant alteration in place preference in mice. In the selfadministration paradigms, 3-FMA showed drug-taking behavior at the dose of 0.1 mg/kg/infusion (i.v.) during 2 hr sessions under fixed ratio schedules and high breakpoints at the dose of 0.3 and 1.0 mg/kg/infusion (i.v.) during 6 hr sessions under progressive ratio schedule of reinforcement in rats. A priming injection of 3-FMA (0.4 mg/kg, i.v.), METH (0.2 mg/kg, i.v.), or cocaine (2.0 mg/kg, i.v.) reinstated 3-FMAseeking behavior after an extinction period in 3-FMA-trained rats during 2 hr session. Taken together, these findings demonstrate robust psychomotor, rewarding and reinforcing properties of 3-FMA, which may underlie its potential for compulsive use in humans.

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The neurochemical consequences of methamphetamine self-administration in male and female rats

Cited by 23 publications

References 31 publications

Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex

Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex

Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration

The potent psychomotor, rewarding and reinforcing properties of 3‐fluoromethamphetamine in rodents

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