The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared

Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study

“…7 Compared with the results of postmortem studies, the reduction of cortical k 3 values in the present AD patients was relatively small, probably because most of our AD patients were in the early stage of the disease. In 4 advanced AD patients in our study, the mean reduction of cortical k 3 values was 37%, which is comparable to the reduction of cortical AChE activity in postmortem studies.…”

Functional Vitamin E Deficiency in <i>ApoE4</i> Patients with Alzheimer’s Disease

“…Moreover both Fe and ascorbate, which together may enhance oxidant production and lipid peroxidation, are found in large quantities in brain tissue. This high oxidative insult is further enhanced in the presence of neurodegenerative disorders, especially AD [1][2][3][4][5] . The presence of amyloid…”

Advanced Oxidation Protein Products in Aged with Dementia

“…Dementia is an imbalance in the radical production and the antioxidative defense leading to oxidative stress. These are considered to have a major role in the process of age-related neurodegeneration [3,4] . AGEs, which are formed by a nonenzymatic glycation and oxidation of proteins and lipids, are potentially toxic to cells and are present in brain plaques in AD [8] .…”

“…A candidate class of secondary toxins, the reactive carbonyls, are products of oxidative damage to lipids, sugars, and amino acids that can irreversibly alkylate and crosslink proteins [2] . Since oxidative stress is characterised by an imbalance in radical production and antioxidative defence, both are considered to have a major role in the process of age-related neurodegeneration [3,4] . Oxidative stress results from a distruption of the natural balance between pro-and -anti-oxidant system in favor of the former [5] .…”