The neurocognitive effects of alcohol on adolescents and college students

Zeigler, Donald; Wang, Claire C.; Yoast, R; Dickinson, Barry D.; McCaffree, Mary Anne; Robinowitz, Carolyn B.; Sterling, Melvyn L.

doi:10.1016/j.ypmed.2004.04.044

Cited by 347 publications

(297 citation statements)

References 60 publications

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“…Alcohol is the most commonly used substance by adolescents and a high percentage of consumption during this period occurs in bingeing or uncontrolled use (Witt, 2010). Importantly, an increasing number of studies have revealed that the adolescent brain is particularly vulnerable to alcohol-induced functional changes (Crews et al, 2007;Guerri and Pascual 2010;Monti et al, 2005;Philpot et al, 2009;Schindler et al, 2014;Squeglia et al, 2012;Zeigler et al, 2005). Moreover, adolescent alcohol use increases the likelihood of developing an alcohol use disorder (AUD) in adulthood (Blomeyer et al, 2013;Dawson et al, 2008;Hingson et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Alcohol, similar to virtually all abused substances, increases dopamine transmission within the ventral striatum (Cheer et al, 2007;Di Chiara and Imperato 1986;. Importantly, the mesolimbic dopamine system continues to mature during the adolescent period (Chambers et al, 2003), suggesting that adolescent alcohol use may alter its function, resulting in abnormal reward-related learning processes that impact decision making (Alaux-Cantin et al, 2013;Casey and Jones 2010;Goudriaan et al, 2007;Johnson et al, 2008;McClory and Spear 2014;Nasrallah et al, 2011;Philpot et al, 2009;Toalston et al, 2014;Zeigler et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Spoelder

Tsutsui

Lesscher

et al. 2015

Neuropsychopharmacol

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Adolescent alcohol use remains a major public health concern due in part to well-established findings implicating the age of onset in alcohol use in the development of alcohol use disorders and persistent decision-making deficits in adults. We have previously demonstrated that moderate adolescent alcohol consumption in rats promotes suboptimal decision making and an associated perturbation in mesolimbic dopamine transmission in adulthood. Dopamine-dependent incentive learning processes are an integral component of value-based decision making and a fundamental element to many theoretical accounts of addiction. Thus we tested the hypothesis that adolescent alcohol use selectively alters incentive learning processes through perturbation of mesolimbic dopamine systems. To assess incentive learning, behavioral and neurochemical measurements were made during the acquisition, maintenance, extinction, and reacquisition of a Pavlovian conditioned approach procedure in adult rats with a history of adolescent alcohol consumption. We show that moderate adolescent alcohol consumption potentiates stimulus-evoked phasic dopamine transmission, measured in vivo by fast-scan cyclic voltammetry, in adulthood and biases individuals toward a dopamine-dependent incentive learning strategy. Moreover, we demonstrate that animals exposed to alcohol in adolescence are more sensitive to an unexpected variation in reward outcomes. This pattern of phasic dopamine signaling and the associated bias in learning may provide a mechanism for the well-documented vulnerability of individuals with early-life alcohol use for alcohol use disorders in adulthood.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Spoelder

Tsutsui

Lesscher

et al. 2015

Neuropsychopharmacol

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“…In Portugal, the studies conducted in the last decade, in 2003,2007 and 2011 respectively, with samples of adolescents and young people with ages between 13 and 18 revealed that the alcohol consumption tends to increase linearly with age, and is larger among males 3 . Although many times those experiences of consumption are socially accepted and culturally justified, studies indicate that alcohol should not be consumed before the age of 18, because the liver is not prepared to metabolize alcohol and the brain is still developing/in maturation 4,5 . Alcohol-related harms resulting from episodes of drunkenness and excessive consumption are known: unprotected sex, violence, driving under the influence of alcohol and school absenteeism, among others.…”

Section: Introductionmentioning

confidence: 99%

Literacia em saude mental de adolescentes e jovens portugueses sobre abuso de alcool

et al. 2013

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Characterize the mental health literacy of adolescents and young people about alcohol abuse, in the various components of the concept. Exploratory descriptive study, through the application of the instrument QuALiSMental to a representative sample of 4938 adolescents and young adults aged between 14 and 24 years, attending schools in the 3rd cycle of basic and secondary education of the central region of Portugal.The recognition of the vignette of alcohol abuse by the participants is high (72.4%), although it is also identified as alcoholism (70.3%), which indicates the perception of the problem as serious. Participants have modest levels of literacy in the remaining components, preferring informal sources of help.Therefore, we conclude that there is a need to implement school programs that promote mental health literacy, to promote the adoption of healthy behaviors in young people, which transfer them into adulthood. RESUMENObjetivo: Caracterizar la instrucción en salud mental de adolescente y jóvenes con respecto al abuso del alcohol, en los diversos componentes del concepto de instrucción. Métodos: Estudio exploratorio-descriptivo, con aplicación del instrumento QuALiSMental a partir de la muestra representativa de 4938 adolescentes y jóvenes adultos, con edades entre 14 y 24 años, que frecuentan escuelas del tercer ciclo de enseñanza básica y de educación secundaria en la región central de Portugal. Resultados: El reconocimiento de la viñeta del abuso de alcohol por los participantes es alto (72,4%), aunque se identifica también como alcoholismo (70,3%), que sin embargo, indica la percepción del problema como siendo grave. Los participantes tienen modestos niveles de instrucción en los componentes restantes, prefiriendo las fuentes informales de ayuda. Conclusión: Se concluye, así, que la necesidad de implementar en las escuelas programas que promueven la instrucción en salud mental para la adopción de conductas saludables en los jóvenes, que los transfieren hacia la edad adulta.Salud mental; Educación en Salud; Alcoholismo; Adolescente.

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“…Although some studies have investigated the role of the Pre-frontal Cortex (PFC) in the vulnerability to experimentation with alcohol, and the acquisition of alcohol disorders in adolescents, most of these studies have focused on the role of the "cold" cognitive aspects of executive functions (EF) in alcohol use, which have been linked to the dorsolateral sector of the prefrontal cortex (DLPC) (Finn, Mazas, Justus, & Steinmetz, 2002;Hartley, Elsabagh, & File, 2004;Sher, 2006;Thush & Wiers, 2007;Zeigler et al, 2005;Zetteler, Stollery, Weinstein, & Lingford-Hughes, 2006). Relatively few studies have addressed the "hot" cognitive aspects of EF in alcohol and other substance use, which have been more linked to the orbital/ventromedial sector of the prefrontal cortex (OFC/VMPC) .…”

Section: Introductionmentioning

confidence: 99%

Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers

et al. 2008

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The primary aim of this study was to test the hypothesis that adolescent binge drinkers, but not lighter drinkers, would show signs of impairment on tasks of affective decision-making as measured by the Iowa Gambling Test (IGT), when compared to adolescents who never drank.We tested 207 10th grade adolescents in Chengdu City, China, using two versions of the IGT, the original and a variant, in which the reward/punishment contingencies were reversed. This enables one to distinguish among different possibilities of impaired decision-making, such as insensitivity to long-term consequences, or hypersensitivity to reward. Furthermore, we tested working memory capacity using the Self-ordered Pointing Test (SOPT). Paper and pencil questionnaires were used to assess drinking behaviors and school academic performance.Results indicated that relative to never-drinkers, adolescent binge drinkers, but not other (ever, past 30-day) drinkers, showed significantly lower net scores on the original version of the IGT especially in the latter trials. Furthermore, the profiles of behavioral performance from the original and variant versions of the IGT were consistent with a decision-making impairment attributed to hypersensitivity to reward. In addition, working memory and school academic performance revealed no differences between drinkers (at all levels) and never-drinkers. Logistic regression analysis showed that after controlling for demographic variables, working memory, and school academic performance, the IGT significantly predicted binge-drinking.These findings suggest that a "myopia" for future consequences linked to hypersensitivity to reward is a key characteristic of adolescents with binge-drinking behavior, and that underlying neural mechanisms for this "myopia" for future consequences may serve as a predisposing factor that renders some adolescents more susceptible to future addictive behaviors.

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The neurocognitive effects of alcohol on adolescents and college students

Cited by 347 publications

References 60 publications

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling

Literacia em saude mental de adolescentes e jovens portugueses sobre abuso de alcool

Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers

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