The neurodevelopmental role of dopaminergic signaling in neurological disorders

Cai, Yunyun; Xing, Lingyan; Yang, Tuo; Chai, Rui; Wang, Jiaqi; Bao, Jingyin; Shen, Weisen; Ding, Sujun; Chen, Gang

doi:10.1016/j.neulet.2020.135540

Cited by 46 publications

(32 citation statements)

References 54 publications

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“…Studies relating behavioural outcomes to dopamine receptor expression found that increased cortical D1 receptor expression increases impulsivity behaviour (Sonntag et al 2014). However, no changes were observed in expression of the dopamine transporter (DAT) in the current study, which is also key for alteration in dopaminergic pathways related to attention and activity (Cai et al 2021).…”

Section: Discussioncontrasting

confidence: 67%

Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood

Wyrwoll

Papini

Chivers

et al. 2021

The Journal of Physiology

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Atmospheric carbon dioxide (CO2) levels are currently at 418 parts per million (ppm), and by 2100 may exceed 900 ppm. The biological effects of lifetime exposure to CO2 at these levels is unknown. Previously we have shown that mouse lung function is altered by long‐term exposure to 890 ppm CO2. Here, we assess the broader systemic physiological responses to this exposure. Mice were exposed to either 460 or 890 ppm from preconception to 3 months of age, and assessed for effects on developmental, renal and osteological parameters. Locomotor, memory, learning and anxiety‐like behaviours of the mice were also assessed. Exposure to 890 ppm CO2 increased birthweight, decreased female body weight after weaning, and, as young adults, resulted in reduced engagement in memory/learning tasks, and hyperactivity in both sexes in comparison to controls. There were no clear anxiety, learning or memory changes. Renal and osteological parameters were minimally affected. Overall, this study shows that exposure of mice to 890 ppm CO2 from preconception to young adulthood alters growth and some behaviours, with limited evidence of compensatory changes in acid–base balance. These findings highlight the potential for a direct effect of increased atmospheric CO2 on mammalian health outcomes. Key points Long‐term exposure to elevated levels of atmospheric CO2 is an uncontrolled experiment already underway. This is the first known study to assess non‐respiratory physiological impacts of long‐term (conception to young adulthood) exposure of mice to CO2 at levels that may arise in the atmosphere due to global emissions. Exposure to elevated CO2, in comparison to control mice, altered growth patterns in early life and resulted in hyperactive behaviours in young adulthood. Renal and bone parameters, which are important to balance acid–base levels to compensate for increased CO2 exposure, remained relatively unaffected. This work adds to the body of evidence regarding the effects of carbon emissions on mammalian health and highlights a potential future burden of disease.

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Section: Discussioncontrasting

confidence: 67%

Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood

Wyrwoll

Papini

Chivers

et al. 2021

The Journal of Physiology

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“…Hyperactivity and inattention may be related to the insu cient function of the catecholamine (i.e., DOPA and NE) system in the brain. According to Cai et al, (2021), ADHD symptoms are associated with decreased synaptic DOPA and NE concentrations. In addition, there is a dysfunction of information transmission between inhibitory synapses and excitatory synapses (Xi, Wu et al, 2021), where occurs an atypical balance of neural excitation and inhibition (E/I) being GABA and glutamate as contributing (Mamiya et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation

Macedo

Antunes

Alvarenga

et al. 2021

Preprint

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Background: Curcumin has protective actions in neuropsychiatric disorders. Its mechanism of action is associated with the restoration of catecholaminergic balance, reduction of oxidative/nitrosative stress, protection against inflammation, and neuroprotection. Objective: In a first approach, the study presents an empty review of the potential effect of curcumin on cognitive performance in attention deficit hyperactivity disorder (ADHD).Methods: On a second moment, seeing the scarcity of studies and knowing that ADHD is related to hyperactive and anxious behavior, 20 spontaneously hypertensive Wistar rats (SHR) were divided into groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field test), anxiety and impulsivity (Elevated Plus Maze, and Social Interaction), and memory (Y Maze and Object Recognition Test) were performed. Results: Animals treated with curcumin showed less anxious and hyperactive behavior. Related to the memory, the results can be related to hyperactivity. Conclusion: Thus, the data suggest that the treatments used here can beneficially modulate the anxious and hyperactive behavior of SHR.

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“…Dopamine (DA), a key neurotransmitter in the central and peripheral nervous systems, is involved in several biological functions and regulates cognitive activities like decision making, attention, memory, motivation, reward, locomotor activity, neuroendocrine regulation, and ingestion of water and food.Dopaminergic signaling dysfunction can result in a variety of mental health issues [13][14][15] . The major neurotransmitter the mesocorticolimbic circuit is DA and this circuit is influenced by changes in the makeup of gut microbes [16] .…”

Section: Dopamine and Gut Microbesmentioning

confidence: 99%

Assistance of Gut Microbiota in Depression

Reji

Krishna²,

Kumar³

2021

J. Drug Delivery Ther.

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The association between gut microbiota and mental health is a relatively new research topic that has gained traction in recent years. Depression is a serious mental illness and a leading cause of disability, morbidity, and mortality worldwide. Based on the WHO reports, there are approximately 350 million people affected by depression globally. Currently available treatments can temporarily alleviate the symptoms of depressive illness, but these management plans are unable to completely reverse the multifactorial pathology of depression, and the antidepressant medications may produce side effects and adverse drug reactions which may turn down the quality of life of patients. Research has shown that the gut microflora interacts with the brain through various mechanisms, and this leads to the recognition of the microbiome in managing mental health. By unveiling the complexities involved in this area can help to develop novel strategies to treat the depressed patients and to prevent the public from falling to depressive disorder. Keywords: Gut microbiome, depression, neurotransmitters

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The neurodevelopmental role of dopaminergic signaling in neurological disorders

Cited by 46 publications

References 54 publications

Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood

Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood

Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation

Assistance of Gut Microbiota in Depression

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The neurodevelopmental role of dopaminergic signaling in neurological disorders

Cited by 46 publications

References 54 publications

Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthood

Long‐term exposure of mice to 890 ppm atmospheric CO2 alters growth trajectories and elicits hyperactive behaviours in young adulthood

Curcumin for Attention Deficit Hyperactivity Disorder: a Behavioral Preliminary Investigation

Assistance of Gut Microbiota in Depression

Contact Info

Product

Resources

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Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood

Long‐term exposure of mice to 890 ppm atmospheric CO₂ alters growth trajectories and elicits hyperactive behaviours in young adulthood