The neuroimaging magnitude of pediatric brain atrophy in northern Tanzania

Sungura, R; Spitsbergen, John M.; Mpolya, Emmanuel; Sauli, Elingarami; Vianney, John-Mary

doi:10.11604/pamj.2020.36.25.22515

Cited by 6 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study was very important and relevant in the planning and designing of brain atrophy mitigation plans in Tanzania and adjacent nations whose incidence in the northern regions currently stands at 14.06 percent [18]. The outcomes of this study are crucial for course-specific brain atrophy intervention approaches.…”

Section: Introductionmentioning

confidence: 95%

A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background The brain volume loss also known as brain atrophy is increasingly observed among children in the course of performing neuroimaging using CT scan and MRI brains. While severe forms of brain volume loss are frequently associated with neurocognitive changes due to effects on thought processing speed, reasoning and memory of children that eventually alter their general personality, most clinicians embark themselves in managing the neurological manifestations of brain atrophy in childhood and less is known regarding the offending factors responsible for developing pre-senile brain atrophy. It was therefore the goal of this study to explore the factors that drive the occurrence of childhood brain volume under the guidance of brain CT scan quantitative evaluation. Methods This study was a case-control study involving 168 subjects with brain atrophy who were compared with 168 age and gender matched control subjects with normal brains on CT scan under the age of 18 years. All the children with brain CT scan were subjected to an intense review of their birth and medical history including laboratory investigation reports. Results Results showed significant and influential risk factors for brain atrophy in varying trends among children including age between 14-17(OR = 1.1), male gender (OR = 1.9), birth outside facility (OR = 0.99), immaturity (OR = 1.04), malnutrition (OR = 0.97), head trauma (OR = 1.02), maternal alcoholism (OR = 1.0), antiepileptic drugs & convulsive disorders (OR = 1.0), radiation injury (OR = 1.06), space occupying lesions and ICP (OR = 1.01) and birth injury/asphyxia (OR = 1.02). Conclusions Pathological reduction of brain volume in childhood exhibits a steady trend with the increase in pediatric age, with space occupying lesions & intracranial pressure being the most profound causes of brain atrophy.

show abstract

Section: Introductionmentioning

confidence: 95%

A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy

Sungura

Mpolya

et al. 2020

European Journal of Radiology Open

View full text Add to dashboard Cite

The focused quantitative EEG bio-marker in studying childhood atrophic encephalopathy

Richard

Gabriel

John

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Although it is a normal involution process in advanced age, brain atrophy—also termed atrophic encephalopathy—can also occur prematurely in childhood as a consequential effect of brain tissues injury through trauma or central nervous system infection, though in both normal and premature occurrences this condition always presents with loss of volume relative to the skull. A common tool for the functional study of brain activities is an electroencephalogram, but analyses of this have reportedly identified mismatches between qualitative and quantitative forms, particularly in the use of Delta-alpha ratio (DAR) indices, meaning that the values may be case dependent. The current study thus examines the value of Focused Occipital Beta-Alpha Ratio (FOBAR) as a modified biomarker for evaluating brain functional changes resulting from brain atrophy. This cross-sectional design study involves 260 patients under 18 years of age. Specifically, 207 patients with brain atrophy are compared with 53 control subjects with CT scan-proven normal brain volume. All the children underwent digital electroencephalography with brain mapping. Results show that alpha posterior dominant rhythm was present in 88 atrophic children and 44 controls. Beta as posterior dominant rhythm was present in an overwhelming 91.5% of atrophic subjects, with 0.009 p-values. The focused occipital Beta-alpha ratio correlated significantly with brain volume loss presented in diagonal brain fraction. The FOBAR and DAR values of the QEEG showed no significant correlation. This work concludes that QEEG cerebral dysfunctional studies may be etiologically and case dependent from the nature of the brain injury. Also, the focused Beta-alpha ratio of the QEEG is a prospective and potential biomarker of consideration in studying childhood atrophic encephalopathy.

show abstract

The neuroimaging magnitude of pediatric brain atrophy in northern Tanzania

Cited by 6 publications

References 49 publications

A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore

A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore

Novel multi-linear quantitative brain volume formula for manual radiological evaluation of brain atrophy

The focused quantitative EEG bio-marker in studying childhood atrophic encephalopathy

Contact Info

Product

Resources

About