The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis

Bowerman, Mélissa; Vincent, Thierry; Scamps, Frédérique; WilliamCamu,; Raoul, Cédric

doi:10.5772/56489

Current Advances in Amyotrophic Lateral Sclerosis 2013

DOI: 10.5772/56489

|View full text |Cite

The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis

Mélissa Bowerman¹,

Thierry Vincent²,

Frédérique Scamps³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 240 publications

(245 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis

Dey,

Kumar,

Patel

2024

View full text Add to dashboard Cite

Amyotrophic Lateral Sclerosis (ALS) is the most common, adult-onset, progressive motor neurodegenerative disorder that results in death within 3 years of the clinical diagnosis. Due to the clinicopathological heterogeneity, any reliable biomarkers for diagnosis or prognosis of ALS have not been identified till date. Moreover, the only three clinically approved treatments are not uniformly effective in slowing the disease progression. Over the last 15 years, there has been a rapid advancement in research on the complex pathomechanistic landscape of ALS that has opened up new avenues for successful clinical translation of targeted therapeutics. Multiple studies suggest that the age-dependent interaction of risk-associated genes with environmental factors and endogenous modifiers is critical to the multi-step process of ALS pathogenesis. In this review, we provide an updated discussion on the dysregulated cross-talk between intracellular homeostasis processes, the unique molecular networks across selectively vulnerable cell types, and the multisystemic nature of ALS pathomechanisms. Importantly, this work highlights the alteration in epigenetic and epitranscriptomic landscape due to gene-environment interactions, which have been largely overlooked in the context of ALS pathology. Finally, we suggest that precision medicine research in ALS will be largely benefitted from the stratification of patient groups based on the clinical phenotype, onset and progression, genome, exposome, and metabolic identities.

show abstract

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis

Dey,

Kumar,

Patel

2024

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The Neuroinflammation in the Physiopathology of Amyotrophic Lateral Sclerosis

Cited by 1 publication

References 240 publications

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis

Contact Info

Product

Resources

About