The neurologic basis of Cheyne-Stokes respiration

Brown, Harold; Plum, Fred

doi:10.1016/0002-9343(61)90173-5

Cited by 139 publications

(41 citation statements)

References 18 publications

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“…b) The absence of significant arterial oxygen unsaturation (except in Cases 5, 8, and 9) is in agreement with other reports (3,5,7). None of the patients appeared cyanotic during any portion of the respiratory cycle, nor was clubbing found.…”

Section: Discussionsupporting

confidence: 91%

The Mechanism of Cheyne-Stokes Respiration*

Lange¹,

Hecht²

1962

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 91%

The Mechanism of Cheyne-Stokes Respiration*

Lange¹,

Hecht²

1962

J. Clin. Invest.

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“…This observation indicates that acute brain stem ischemic lesions may result in respiratory rate and pattern abnormalities without the presence of concomitant systemic diseases, as observed by others in patients with CSR. 6 Other investigators 28 have suggested that specific respiratory rate and pattern abnormalities may be correlated with the location of the central nervous system lesions. In this study, however, the types of respiratory rate and pattern abnormalities in acute brain stem infarction were not specifically related to the level of the lesions but rather to the extent and bilaterality of the lesions.…”

Section: Discussionmentioning

confidence: 98%

Respiratory rate and pattern disturbances in acute brain stem infarction.

Lee¹,

Klassen²,

Heaney³

et al. 1976

Stroke

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SUMMARY Respiratory rates and patterns were studied in 23 patients with acute brain stem infarction using impedance pneumography. Autopsy was obtained in six of eight fatal cases. Pontine lesions were present in all patients, with coexistent infarction of midbrain in four and of medulla in nine. Respiratory rate and pattern abnormalities observed included Cheyne-Stokes respiration, CheyneStokes variant pattern and tachypnea. Abnormalities of respiratory rate and pattern of varying duration were observed at some time in all patients. All patients in whom prominent Cheyne-Stokes respiration or tachypnea were observed had extensive bilateral pontine lesions involving both basal and tegmental portions. However, not all patients with large pontine infarcts had Cheyne-Stokes respiration or tachypnea. Cheyne-Stokes respiration was prominent in four patients (two fatal, two nonfatal). Cheyne-Stokes variant pattern was present frequently in four patients (one fatal, three nonfatal). Sustained tachypnea developed in five patients, four of whom died. In ten patients (one fatal, nine nonfatal), normal respiratory rate and pattern predominated with only rare or occasional appearance of Cheyne-Stokes respiration or Cheyne-Stokes variant pattern, especially during sleep. The types of respiratory rate and pattern abnormalities in acute brain stem infarction were not specifically related to the level of lesions, but rather to the size and bilaterality of the lesions. Respiratory alkalosis was present in varying degrees in most patients with either tachypnea or prominent CSR.

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“…Since PB at high altitude was first reported, its cause and mechanism have been investigated in order to explain the pathogenesis of Cheyne-Stokes respiration found in patients with congestive heart failure (PRYOR, 1951) or central nervous system disorder (BROWN and PLUM, 1961). PB has been induced experimentally (CHERNIACK et al, 1979;LAHIRI et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Periodic breathing at high altitude and ventilatory responses to O2 and CO2.

et al. 1989

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To determine the relationship between periodic breathing (PB) during sleep at high altitude and ventilatory chemosensitivities, we studied nine Japanese climbers who participated in the expedition to the Kunlun Mountains (7,167m) in China in 1986. At sea level, ventilatory response to hypoxia (HVR) by isocapnic progressive hypoxia test and to hypercapnia (HCVR) by Read's method were examined. At altitude 5,360 m, respiratory movements of the chest and abdominal wall, Saoz, ECG, and HR were monitored. Seven climbers manifested PB during sleep. There was a significant correlation between PB during sleep and HVR and HCVR (p <0.05). All the climbers showed severe desaturation during sleep. There was a significant negative correlation between degree of desaturation during sleep and HVR (p <0.05). A negative correlation was also detected between PB and the degree of desaturation during sleep. We concluded that ventilatory chemosensitivities play an important role in eliciting PB and that climbers with high HVR can maintain their arterial oxygenation during sleep, due to hyperventilation induced by PB, which is considered an advantageous adaptation for lowland sojourners.

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The neurologic basis of Cheyne-Stokes respiration

Cited by 139 publications

References 18 publications

The Mechanism of Cheyne-Stokes Respiration*

The Mechanism of Cheyne-Stokes Respiration*

Respiratory rate and pattern disturbances in acute brain stem infarction.

Periodic breathing at high altitude and ventilatory responses to O2 and CO2.

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