The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract

Dockray, Graham J.; Vaillant, Camille; Walsh, John H.

doi:10.1016/0306-4522(79)90019-8

Cited by 311 publications

(89 citation statements)

References 7 publications

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“…This relationship suggests the presence of bombesin-or GRPimmunoreactive cells in the caiman stomach. However, bombesin immunoreactivities were not observed in cells of the fundic glands and were found only in the intramural nerve fibers as reported in the mammalian stomach (DoCKRAY et al, 1979). This results suggests that the caiman stomach may more closely resemble the stomach of mammals than that of other reptiles and birds.…”

Section: Discussionsupporting

confidence: 58%

An immunohistochemical study of the endocrine cells in the gastrointestinal mucosa of the Caiman latirostris.

Yamada

Campos

Kitamura

et al. 1987

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary.Twelve endocrine cell types immunoreactive for either 5-hydroxytryptamine Moderate numbers of neurotensin-immunoreactive cells and a few 5-HT-immunoreactive cells were found also in the cloaca. Cells immunoreactive for gastrin releasing polypeptide, bombesin and gastric inhibitory peptide were not observed in the caiman gastrointestinal epithelium. The differences in endocrine cell types between the caiman and alligator are discussed in terms of their topographic distribution.

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Section: Discussionsupporting

confidence: 58%

An immunohistochemical study of the endocrine cells in the gastrointestinal mucosa of the Caiman latirostris.

Yamada

Campos

Kitamura

et al. 1987

Arch. Histol. Jap., Arch. Histol. Jpn

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“…In fact, the rat gastric submucosal and myenteric neurons express CaR (9). GRP neuropetidesecreting intramural neurons project to the antral mucosa and stimulate gastrin secretion through G-cell GRPR-1 [bombesin subtype 1 receptor (BB1R)] receptors (45,46). Pharmacologic studies using the BB1R subtype selective antagonist, [Leu 13 -ψ(CH 2 NH)−Leu 14 ] bombesin, indicate that gastric GRP neurons in rat antral mucosal segments and isolated whole rat stomach (37, 47) mediate peptone-stimulated gastrin release.…”

Section: G-cell Cars Are the Predominant Chemosensors Mediating Gastrinmentioning

confidence: 99%

Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

Feng

Petersen²,

Coy³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

123

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The calcium-sensing receptor (CaR) is the major sensor and regulator of extracellular Ca 2+ , whose activity is allosterically regulated by amino acids and pH. Recently, CaR has been identified in the stomach and intestinal tract, where it has been proposed to function in a non-Ca 2+ homeostatic capacity. Luminal nutrients, such as Ca 2+ and amino acids, have been recognized for decades as potent stimulants for gastrin and acid secretion, although the molecular basis for their recognition remains unknown. The expression of CaR on gastrin-secreting G cells in the stomach and their shared activation by Ca 2+ , amino acids, and elevated pH suggest that CaR may function as the elusive physiologic sensor regulating gastrin and acid secretion. The genetic and pharmacologic studies presented here comparing CaR-null mice and wild-type littermates support this hypothesis. Gavage of Ca 2+ , peptone, phenylalanine, Hepes buffer (pH 7.4), and CaR-specific calcimimetic, cinacalcet, stimulated gastrin and acid secretion, whereas the calcilytic, NPS 2143, inhibited secretion only in the wild-type mouse. Consistent with known growth and developmental functions of CaR, G-cell number was progressively reduced between 30 and 90 d of age by more than 65% in CaR-null mice. These studies of nutrient-regulated G-cell gastrin secretion and growth provide definitive evidence that CaR functions as a physiologically relevant multimodal sensor. Medicinals targeting diseases of Ca 2+ homeostasis should be reviewed for effects outside traditional Ca 2+ -regulating tissues in view of the broader distribution and function of CaR.

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“…Vagal nerve has stimulatory and inhibitory actions on acid secretion [15,16] and it contains and releases several neurotransmitters such as acetylcholine [17] , gastrin-releaseing peptide (GRP) [18] , substance P [19] . Calcitonin gene-related peptide [19] and pituitary adenylate cyclase activating peptide (PACAP) [20] .…”

Section: Ghrelin and Histamine Releasementioning

confidence: 99%

Ghrelin and gastric acid secretion

Yakabi¹,

Kawashima²,

Kato³

2008

WJG

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The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract

Cited by 311 publications

References 7 publications

An immunohistochemical study of the endocrine cells in the gastrointestinal mucosa of the Caiman latirostris.

An immunohistochemical study of the endocrine cells in the gastrointestinal mucosa of the Caiman latirostris.

Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

Ghrelin and gastric acid secretion

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