The neuropathology of stillbirth — Correlation with apolipoprotein genotype in a Scottish population based study

Bell, Jeanne E.; Becher, Julie-Clare; Keeling, Jean W.; McIntosh, Neil

doi:10.1016/j.earlhumdev.2014.12.008

Cited by 3 publications

(2 citation statements)

References 61 publications

(102 reference statements)

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“…At a more speculative level, we retain that the possible early life effects associated with APOE polymorphism could primarily act on the cholesterol metabolism during the development of the brain and other organs and apparatuses (vascular system, liver, lungs, kidneys, etc.). Theoretically, APOE could also manifest a protective or detrimental effect on the brain development or its functions through indirect pathways [126,127]. Pivotal MRI-imaging studies focusing on morphometric aspects of gray matter (GM) in very preterm infants seem to predict some future aspects of neurodevelopmental outcomes [128].…”

Section: Apoe Polymorphism In Normal and Pathologic Conditions Of Thementioning

confidence: 99%

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Iacono

Feltis

2019

Aging

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The central nervous system (CNS) is the cellular substrate for the integration of complex, dynamic, constant, and simultaneous interactions among endogenous and exogenous stimuli across the entire human lifespan. Numerous studies on aging-related brain diseases show that some genes identified as risk factors for some of the most common neurodegenerative diseases - such as the allele 4 of APOE gene (APOE4) for Alzheimer’s disease (AD) - have a much earlier neuro-anatomical and neuro-physiological impact. The impact of APOE polymorphism appears in fact to start as early as youth and early-adult life. Intriguingly, though, those same genes associated with aging-related brain diseases seem to influence different aspects of the brain functioning much earlier actually, that is, even from the neonatal periods and earlier. The APOE4, an allele classically associated with later-life neurodegenerative disorders as AD, seems in fact to exert a series of very early effects on phenomena of neuroplasticity and synaptogenesis that begin from the earliest periods of life such as the fetal ones.We reviewed some of the findings supporting the hypothesis that APOE polymorphism is an early modifier of various neurobiological aspects across the entire human lifespan - from the in-utero to the centenarian life - during both normal and pathological conditions of the brain.

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Section: Apoe Polymorphism In Normal and Pathologic Conditions Of Thementioning

confidence: 99%

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Iacono

Feltis

2019

Aging

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“…5,6 Her participation in a collaborative study of Scotland-wide perinatal brain pathology continued for several years into her retirement from practice. 7…”

Section: Research and Expertisementioning

confidence: 99%

Jean W Keeling

Khong

Malcomson

2019

Pediatr Dev Pathol

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Silver Nanoparticles in The Fetal Brain: New Perspectives in Understanding The Pathogenesis of Unexplained Stillbirths

Gatti¹,

Montanari²,

Ferrero

et al. 2021

Nanomedicine (Lond.)

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We report, for the first time, the surprising presence of toxic nanoparticles, especially silver, in the brain of a fetus, who died unexpectedly at the end of a regular pregnancy. After an accurate autopsy, including the examination of the fetal annexes, an in-depth anatomopathological study of the nervous system and a search by scanning electron microscopy of nanoparticles in the brain, we highlighted the sequence of events that may have led to this fetal death, triggered primarily by the transition of nanosized xenobiotics from the mother to the fetal bloodstream. From this report emerges the importance of considering the search of nanosubstances in the brain during routine investigations following unexpected and unexplained fetal and infant deaths.

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The neuropathology of stillbirth — Correlation with apolipoprotein genotype in a Scottish population based study

Cited by 3 publications

References 61 publications

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Jean W Keeling

Silver Nanoparticles in The Fetal Brain: New Perspectives in Understanding The Pathogenesis of Unexplained Stillbirths

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