The Neuropathy of Multiple Myeloma

The relation between chronic polyneuropathy and osteosclerotic myeloma.

“…The histology of the osteosclerosis is described briefly by Victor et al (1958), Aguayo et al (1964), Rushton (1965), and in our case 1. There was dense new bone formation in the intertrabecular spaces accompanied by increased reticulin surrounding the myeloma and loss of bone within the lesion.…”

“…In two recent descriptions the writers comment on the unusual osteosclerotic myeloma in their cases (Small, Moxon, and Woolf, 1961;Aguayo, Thompson, and Humphrey, 1964), and ask whether this is more than a chance association. Aguayo et al (1964) Brain (1965) Murphy and Little (1966) This report (case 4) Osteolytic radiologicalfeatures Kurnick and Yolahem (1948) case 2 Victor et al (1958) case 3 Williams et al (1959) case R. S. Furtado (1959) Ojea et al (1961) No radiological abnormality Berlin (1946) Estes and Millikan (1954) Clarke (1956) Victor et al (1958) case 4 The relation between chronic polyneuropathy and osteosclerotic myeloma Radiographs of the pelvis revealed an osteolytic area in the right acetabulum ( Fig. 4) (Fig.…”

“…Amyloid and myelomatous infiltration are not present. These changes are accepted as being identical to those of carcinomatous mixed sensory-motor neuropathy (Victor et al, 1958;Small et al, 1961;Simpson, 1962;Rushton, 1965).…”

“…These numbers do not include certain other reports (Kurnick and Yolahem, 1948, cases 1 and 3; Madonick and Solomon, 1953;Victor, Banker, and Adams, 1958, case 5; Williams, Diamond, Craver, and Parsons, 1959, case J. G.; Barron, Rowland, and Zimmerman, 1960;and Bibliography-1'2), some of which do not describe the cases; in some the clinical picture was complicated by myelomatous compression or infiltration, or amyloid deposition, and in some the neuropathy was not a chronic symmetrical polyradiculoneuropathy. In two recent descriptions the writers comment on the unusual osteosclerotic myeloma in their cases (Small, Moxon, and Woolf, 1961;Aguayo, Thompson, and Humphrey, 1964), and ask whether this is more than a chance association.…”

Cerebral involvement in multiple myeloma: case report.

“…Involvement of the nervous system, one of the more common complications ofmultiple myeloma (Clarke, 1954), usually takes the form of 'myelomatous paraplegia' due either to compression of the spinal cord by extradural deposits of myeloma or, more rarely, to a collapsed vertebra (Victor et al, 1958 …”