The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish

Anneser, Lukas; Gemmer, Anja; Eilers, Tim; Alcantara, Ivan C.; Loos, Anett-Yvonn; Ryu, Soojin; Schuman, Erin M.

doi:10.1016/j.isci.2022.103868

Cited by 12 publications

(4 citation statements)

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“…This might suggest the dorsal thalamus as a possible multisensory area integrating sensory signals of conspecifics. Recently, a loss-offunction mutation in the gene pth2 lowered shoal cohesion in adults (Anneser et al, 2022), suggesting a role of this hormone in regulating downstream signals important for shoaling.…”

Section: Neural Circuits For Quantities In Zebrafish: Social Behavior...mentioning

confidence: 99%

Quantity as a Fish Views It: Behavior and Neurobiology

et al. 2022

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An ability to estimate quantities, such as the number of conspecifics or the size of a predator, has been reported in vertebrates. Fish, in particular zebrafish, may be instrumental in advancing the understanding of magnitude cognition. We review here the behavioral studies that have described the ecological relevance of quantity estimation in fish and the current status of the research aimed at investigating the neurobiological bases of these abilities. By combining behavioral methods with molecular genetics and calcium imaging, the involvement of the retina and the optic tectum has been documented for the estimation of continuous quantities in the larval and adult zebrafish brain, and the contributions of the thalamus and the dorsal-central pallium for discrete magnitude estimation in the adult zebrafish brain. Evidence for basic circuitry can now be complemented and extended to research that make use of transgenic lines to deepen our understanding of quantity cognition at genetic and molecular levels.

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Section: Neural Circuits For Quantities In Zebrafish: Social Behavior...mentioning

confidence: 99%

Quantity as a Fish Views It: Behavior and Neurobiology

et al. 2022

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“…Activation of PTH2R increases intracellular cAMP levels and can modulate neuroendocrine activity in the hypothalamic–pituitary–adrenal (HPA) axis ( Dimitrov and Usdin, 2010 ). PTH2–PTH2R signaling influences several behaviors, including maternal care ( Cservenák et al, 2013 ), pain sensitivity ( Dimitrov et al, 2010 ; Dimitrov et al, 2013 ; LaBuda and Usdin, 2004 ), and anxiety-like responses ( Anneser et al, 2022 ; Coutellier and Usdin, 2011 ; LaBuda et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

“…Recent work suggests that Pth2 signaling promotes social interactions between conspecifics. In zebrafish, pth2 mutants exhibit decreased preference for conspecifics ( Anneser et al, 2022 ), while chemogenetic activation of the Pth2-positive region of the rodent brain promotes social contact ( Keller et al, 2022 preprint). Consistent with this, expression of pth2 itself positively scales with the quantity of social interactions with conspecifics ( Anneser et al, 2020 ; Anneser et al, 2022 ; Keller et al, 2022 preprint).…”

Section: Introductionmentioning

confidence: 99%

“…In zebrafish, pth2 mutants exhibit decreased preference for conspecifics ( Anneser et al, 2022 ), while chemogenetic activation of the Pth2-positive region of the rodent brain promotes social contact ( Keller et al, 2022 preprint). Consistent with this, expression of pth2 itself positively scales with the quantity of social interactions with conspecifics ( Anneser et al, 2020 ; Anneser et al, 2022 ; Keller et al, 2022 preprint). In rodents, physical touch from conspecifics activates Pth2 expression ( Cservenák et al, 2013 ; Keller et al, 2022 preprint).…”

Section: Introductionmentioning

confidence: 99%

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Alone in a crowd: effect of a nonfunctional lateral line on expression of the social hormone parathyroid hormone 2

et al. 2022

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Parathyroid hormone 2 (Pth2) is a vertebrate-specific neuropeptide whose thalamic expression is upregulated by social contact with conspecifics. However, social interactions fail to stimulate pth2 expression in isolated zebrafish whose lateral line hair cells have been chemically ablated. These results suggest that modulation of pth2 by social context is acutely dependent on mechanosensory information from the lateral line. However, it is unclear how a congenital loss of lateral line function influences the ability of zebrafish to interpret their social environment. In this study, we measure pth2 levels in zebrafish mutants lacking hair cell function in either the lateral line only, or in both the inner ear and lateral line. Socially-raised lateral line mutants express lower levels of pth2 relative to wild type siblings, but there is no further reduction when all sensory hair cells are nonfunctional. However, social isolation of hair cell mutants causes a further reduction in pth2 expression, pointing to additional unidentified sensory cues that influence pth2 production. Lastly, we report that social context modulates fluorescent transgenes driven by the pth2 promoter. Altogether, these data suggest that lateral line mutants experience a form of isolation, even when raised in a social environment.

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