The Neuroprotective Effect of Carvedilol on Diabetic Neuropathy: An In Vitro Study

Magadmi, Rania; Alsulaimani, Mujahid A; Alrafiah, Aziza; Esmat, Ahmed

doi:10.1155/2021/6927025

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…Consideration is mainly due to the fact that carvedilol is a nonselective β -blocker that selectively blocks the receptors along with the full range of B receptors [ 29 ]. At the same time, carvedilol is able to increase insulin sensitivity and improve lipid and glucose metabolism in general, which is related to the receptor blocker effect of carvedilol as well as elevating lipid oxidase activity and regulating disordered lipid and glucose metabolism [ 30 ]. Thus, carvedilol is effective in lowering blood pressure while having effects that are not found in other β -blockers, which improve insulin sensitivity [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension

Zhang

Deng

et al. 2022

Computational and Mathematical Methods in Medicine

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Refractory hypertension seriously affects the life safety of patients. To investigate the effect of carvedilol combined with conventional antihypertensive therapy on blood pressure, blood sugar, blood lipids, and cardiovascular and cerebrovascular complications in elderly patients with refractory hypertension, a total of 80 elderly patients with refractory hypertension who were admitted from June 2019 to September 2021 were selected as the retrospective research objects and divided into the observation group and the control group according to the random number table method, 40 cases in each group, and the control group received conventional antihypertensive therapy. On this basis, the observation group was treated with carvedilol, and the effects of blood pressure, blood sugar, blood lipids, and cardiovascular and cerebrovascular complications were analyzed in the two groups. After treatment, the systolic blood pressure, diastolic blood pressure, adrenal medulla (AM), and endothelin (ET) of the observation group were significantly lower than those of the control group, but the heart rate and NO of the observation group were significantly higher than those of the control group. After treatment, the fasting blood glucose, insulin, triacylglycerol (TG), cholesterol (CHO), and low-density lipoprotein (LDL-C) of the observation group were significantly higher than those of the control group, but the ISI and HDL-C of the observation group were significantly lower than those of the control group. After treatment, the levels of IL-1β, IL-6, TNF-α, UAER, BUN, and SCr in the observation group were significantly lower than those in the control group. The TC of the observation group was lower than that of the control group. Combination therapy has a remarkably stable, sustained, and safe antihypertensive effect on patients with refractory hypertension.

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Section: Discussionmentioning

confidence: 99%

Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension

Zhang

Deng

et al. 2022

Computational and Mathematical Methods in Medicine

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“…It has been shown to exhibit antioxidant activity (Pereira et al, 2011;Arab and El-Sawalhi, 2013;Yasar et al, 2013;Diogo et al, 2017) and prevent reduction of nerve conduction velocity (Cotter and Cameron, 1995). Most recently, carvedilol has been revealed by Magadmi et al (Magadmi et al, 2021) to display a neuroprotective effect in vitro in high glucose-induced neuronal damage on cultured dorsal root ganglia. Hence, this work has been extended to investigate in vivo the potential neuroprotective effect of carvedilol on STZ-induced DN in rat model.…”

Section: Discussionmentioning

confidence: 99%

Carvedilol Exerts Neuroprotective Effect on Rat Model of Diabetic Neuropathy

et al. 2021

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Diabetic neuropathy (DN) commonly occurs in diabetics, affecting approximately 50% of both type 1 and 2 diabetic patients. It is a leading cause of non-traumatic amputations. Oxidative stress could play a key role in the pathophysiology of DN. This study aimed to investigate the potential neuroprotective effect of carvedilol on STZ-induced DN in rats. Thirty male Sprague Dawley rats (weighing 200–250 g) were randomly divided into five groups (six/group), where group 1 (negative control) received only the vehicle (0.5% of carboxymethyl cellulose orally 1 ml/kg). DN was induced by a single injection of remaining rats with streptozotocin (STZ; 50 mg/kg, i.p.). After diabetes induction, group 2 served as the diabetic untreated animals; while groups 3 and 4 were treated with carvedilol (1 and 10 mg/kg/d, orally, respectively). Group 5 received a-lipoic acid as a reference neuroprotective (100 mg/kg/d, orally). All treatments were continued for 45 days after diabetes induction, followed by behavioural tests. After sacrificing the animals, dorsal root ganglia, and sciatic nerves were collected for histopathological examination and biochemical assessments. Briefly, STZ administration caused cold allodynia, induced oxidative stress, and increased nerve growth factor (NGF) concentration. Nevertheless, carvedilol improved the behavioural tests, ameliorated the oxidative imbalance as manifested by reducing malondialdehyde, restoring glutathione content, and superoxide dismutase activity. Carvedilol also decreased NGF concentration in DRG homogenate. In conclusion, this study demonstrates the neuroprotective effect of carvedilol in an experimentally induced DN rat model through–at least partly–its antioxidant effect and reduced NGF concentration in DRG.

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“…Diabetic peripheral neuropathy is presented as spontaneous pain and hyperalgesia due to hyperglycemia-induced sensory neuronal dysfunction [15,16]. A large and growing body of literature has indicated that hyperglycemia-induced oxidative stress and inflammation are key pathways in developing diabetic neuropathy [4].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Red Sea Marine Sponge Xestospongia testudinaria Extract Using In Vitro and In Vivo Diabetic Peripheral Neuropathy Models

et al. 2022

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Diabetic peripheral neuropathy (DPN) is a common complication of diabetes. Oxidative stress plays an important role in the pathophysiology of DPN. Red Sea marine sponge Xestospongia testudinaria extract has a promising neuroprotective effect, presumably owing to its antioxidant and anti-inflammatory properties. Thus, this study aimed to investigate the neuroprotective effect of the sponge X. testudinaria extract on in vitro and in vivo models of DPN. Mice dorsal root ganglia (DRG) were cultured with high glucose (HG) media and used as an in vitro model of DPN. Some of the DRGs were pre-treated with 2 mg/mL of X. testudinaria. The X. testudinaria extract significantly improved the HG-induced decreased neuronal viability and the neurite length. It improved the oxidative stress biomarkers in DRG cultures. The DPN model was induced in vivo by an injection of streptozotocin at a dose of 150 mg/kg in mice. After 35 days, 0.75 mg/kg of the X. testudinaria extract improved the hot hyperalgesia and the DRG histology. Although the sponge extract did not reduce hyperglycemia, it ameliorated the oxidative stress markers and pro-inflammatory markers in the DRG. In conclusion, the current study demonstrates the neuroprotective effect of Red Sea sponge X. testudinaria extract against experimentally induced DPN through its antioxidant and anti-inflammatory mechanisms.

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The Neuroprotective Effect of Carvedilol on Diabetic Neuropathy: An In Vitro Study

Cited by 8 publications

References 39 publications

Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension

Effects of Carvedilol on Blood Pressure, Blood Sugar, and Blood Lipids in Elderly Patients with Refractory Hypertension

Carvedilol Exerts Neuroprotective Effect on Rat Model of Diabetic Neuropathy

Neuroprotective Effect of Red Sea Marine Sponge Xestospongia testudinaria Extract Using In Vitro and In Vivo Diabetic Peripheral Neuropathy Models

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