The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway

Namgyal, Dhondup; Ali, Sher; Mehta, Rachna; Sarwat, Maryam

doi:10.1016/j.tox.2020.152542

Cited by 46 publications

(31 citation statements)

References 43 publications

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“…The earlier findings 29 More recently, the promotion effect of curcumin treatment on neurogenesis and memory was found to be via activation of adenosine monophosphate-activated protein kinase (AMPK)/c-Jun N-terminal kinase (JNK) signaling, which mediated both mammalian target of rapamycin (mTOR) inhibition and B-cell lymphoma-2 (Bcl-2) upregulation and in turn respectively enhanced autophagy and suppressed apoptosis in hippocampus. 30,31…”

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Chronic Pain and Improves Cognitive Impairment via Enhancing Hippocampal Neurogenesis in Sciatic Nerve Constriction Rats

Du¹,

Deng²,

Qiu³

et al. 2021

JPR

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Cognitive impairment is a complication that most frequently happens in patients with chronic neuropathic pain and has limited effective therapy. The aim of this study was to explore the effects of curcumin on the cognitive deficit in rats with peripheral nerve injury induced-neuropathic pain. Methods: The neuropathic pain rat model was constructed using chronic constriction injury (CCI). The curcumin (60 mg/kg) or vehicle was intraperitoneally administered once a day, beginning at 14th day after surgery and continued for 14 consecutive days. The nociceptive threshold tests were measured by paw mechanical withdraw threshold (PMWT) and paw thermal withdrawal latency (PTWL), while the spatial memory abilities were evaluated by the Morris water maze test. The mean counts of bromodeoxyuridine (Brdu)/neuronal nuclei (NeuN) as well as Brdu/doublecortin (DCX) co-labeled cells were used to evaluate neurogenesis in the dentate gyrus of hippocampus. The ultrastructure of the synapse in hippocampal region was visualized using transmission electron microscopy (TEM). Results: Increased PMWT and PTWL, as well as relieved memory deficits, were found in CCI rats under curcumin administration. Moreover, curcumin treatment increased the number of newly born immature (BrdU/NeuN) and newly generated mature neurons (BrdU/ DCX). The TEM examination revealed increased PSD thickness and shorter active zone length as well as narrowed synaptic cleft width in the hippocampal region of CCI rats after curcumin injection. Conclusion: Curcumin can alleviate CCI induced nociceptive behaviors and memory deficit. This effect might be associated with hippocampal neurogenesis and synaptic plasticity improvements, which indicated curcumin as a potential strategy for the cognitive impairment restoration under prolonged neuropathic pain condition.

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Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Chronic Pain and Improves Cognitive Impairment via Enhancing Hippocampal Neurogenesis in Sciatic Nerve Constriction Rats

Du¹,

Deng²,

Qiu³

et al. 2021

JPR

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“…However, the administration of curcumin (150mg/kg) had effectively restored some of the anxiety-like behaviors including the percentage freezing time and frequency of grooming in mice. Corroborating this finding, in our previous study, we observed that the administration of curcumin in the Cd-induced neurotoxic mice model and normal light/dark-exposed mice revealed increased locomotor activity, reduced stress and anxiety-like behavior, and improved spatial learning and retention memory through the promotion of hippocampal neurogenesis [ 21 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 61%

Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms

Namgyal

Chandan

Ali

et al. 2021

Animals

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In the modern research field, laboratory animals are constantly kept under artificial lighting conditions. However, recent studies have shown the effect of artificial light on animal behavior and metabolism. In the present study on mice, following three weeks of housing in dim light at night (dLAN; 5lux) and complete darkness (DD; 0lux), we monitored the effect on body weight, daily food intake, anxiety-like behavior by employing the open field test, and expression of the period (PER1) gene. We also studied the effect of oral administration of different concentrations of curcumin (50, 100, and 150 mg/kg) for three weeks in the same mice and monitored these parameters. The exposure to dLAN had significantly increased the anxiety-like behavior and body weight possibly through the altered metabolism in mice, whereas exposure to DD caused increased anxiety but no significant difference in weight gain. Moreover, the expression of the PER1 gene involved in sleep was also found to be decreased in the aberrant light conditions (dLAN and DD). Although the treatment of curcumin had no effect on body weight, it ameliorated the anxiety-like behavior possibly by modulating the expression of the PER1 gene. Thus, alteration in the light/dark cycle had a negative effect on laboratory animals on the body weight and emotions of animals. The present study identifies the risk factors associated with artificial lighting systems on the behavior of laboratory animals and the ameliorative effects of curcumin, with a focus on anxiety-like behavior.

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“…In an in vitro experimental model of neurodegenerative disease, Armagan and Naziroglu [11] reported the neuroprotective action of curcumin by modulating oxidative stress. In addition, this polyphenol is capable to decrease neurotoxicity, which is proven by other models of neurological disorders in vitro [11][12][13][14][15] and in vivo studies [16,17].…”

Section: Introductionmentioning

confidence: 88%

Impact of Free Curcumin and Curcumin Nanocapsules on Viability and Oxidative Status of Neural Cell Lines

Bissacotti

Copetti

Gündel

et al. 2021

Preprint

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Curcumin is an active polyphenol substance found in the highest concentrations in the roots of Curcuma longa. Its health benefits have led to recent increases in the consumption of curcumin. It has anti-inflammatory and antioxidant activities and is a potent neuroprotective against diseases of the brain. Nevertheless, its low bioavailability and its relative difficulty crossing the blood-brain barrier limit curcumin’s use for these purposes. Curcumin-loaded nanoparticles may be an effective treatment for several diseases although there is a paucity of studies reporting its safety in the central nervous system (CNS). Therefore, this study aimed to identify non-neurotoxic concentrations of free curcumin and two nanoformulations of curcumin. Cell lines BV-2 and SH-SY5Y, both originating from the CNS, were evaluated after 24, 48, and 72 h of treatment with free curcumin and nanocapsules We measured viability, proliferation and dsDNA levels. We measured levels of reactive oxygen species and nitric oxide as proxies for oxidative stress in culture supernatants. We found that free curcumin was toxic at 10 and 20 µM, principally at 72 h. Nanoformulations were more neurotoxic than the free form. Safe concentrations of free curcumin are between 1-5 µM, and these concentrations were lower for nanoformulations. We determined the ideal concentrations of free curcumin and nanocapsules serving as a basis for studies of injuries that affect the CNS.

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The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway

Cited by 46 publications

References 43 publications

Curcumin Alleviates Chronic Pain and Improves Cognitive Impairment via Enhancing Hippocampal Neurogenesis in Sciatic Nerve Constriction Rats

Curcumin Alleviates Chronic Pain and Improves Cognitive Impairment via Enhancing Hippocampal Neurogenesis in Sciatic Nerve Constriction Rats

Aberrant Lighting Causes Anxiety-like Behavior in Mice but Curcumin Ameliorates the Symptoms

Impact of Free Curcumin and Curcumin Nanocapsules on Viability and Oxidative Status of Neural Cell Lines

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