The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer’s disease

Mataram, Made bagus Auriva; Hening, Puspa; Harjanti, Fitria N.; Karnati, Srikanth; Wasityastuti, Widya; Nugrahaningsih, Dwi Aris Agung; Kusindarta, Dwi Liliek; Wihadmadyatami, Hevi

doi:10.1016/j.jchemneu.2020.101885

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…In the current research, we preferred to have a pretreatment, preventive, and neuroprotective strategy and not a post-treatment and restorative design and accordingly we administered kolaviron before okadaic acid microinjection. Such design for Alzheimer's-like phenotype and under neurotoxic conditions is according to literature [ [68] , [69] , [70] , [71] ]. However, as a limitation, it is recommended to evaluate the beneficial and restorative effect of kolaviron post-treatment in OA model of AD like phenotype in future studies.…”

Section: Discussionmentioning

confidence: 99%

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment

Nazari-Serenjeh,

Baluchnejadmojarad,

Hatami-Morassa

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment

Nazari-Serenjeh,

Baluchnejadmojarad,

Hatami-Morassa

et al. 2024

Heliyon

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“…Another study showed that the administration of NPE was able to prevent the deficits in the number of pyramidal cells in the cornu ammonis 1 (CA1) region of the hippocampus and cerebral cortex of TMT-exposed mice. Previous studies have reported that the administration of TMT at a dose of 8 mg/kg BW caused widespread damage to the neurons in the hippocampal area, as demonstrated by significant decreases in the number of neurons in the stratum pyramidal of CA1, CA3, and dentate gyrus (DG) in a rat model of AD (21). The increase in reactive oxygen species associated with oxidative stress plays an important role in mediating TMT-inducing neurotoxic damage.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of water lily (Nymphaea pubescens Willd) seed ethanolic extract against trimethyltin-induced cognitive impairment and neurodegeneration in mice

Belahusna,

Santoso,

Rahayu

2023

J Herbmed Pharmacol

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Introduction: Cognitive impairments are profound outcomes of neurodegenerative disease, a global health issue. Water lily (Nymphaea pubescens, Nymphaeaceae) extracts have been reported to counteract oxidative stress. However, their protective effects against neurodegenerative disease remain to be fully investigated. The current study aimed to determine the neuroprotective effect of water lily seed ethanolic extract on trimethyltin (TMT)-induced cognitive impairment and neurodegeneration in a mouse model. Methods: A single dose of TMT (0.6 mg/kg BW) was intraperitoneally injected to young adult male mice followed by daily oral treatments with different doses of water lily seed extract (0, 100, 200, and 400 mg/kg BW) for 28 days. Thereafter, cognitive behaviors were assessed, malondialdehyde (MDA) levels and catalase (CAT) activities were determined, followed by histopathological examination of the brain. Results: The results revealed that, compared to the non-treated group, the water lily extract at doses of 100–400 mg/kg BW was effective in counteracting the decline in memory and spatial cognition of TMT-induced impairment (P<0.05). Moreover, the extract, particularly at doses of 200 and 400 mg/kg BW, substantially lowered the MDA level while elevating the CAT activity level (P<0.05). Water lily seed extract also significantly reduced TMT-induced pyramidal cell degeneration in the hippocampus and cerebral cortex (P<0.05). Conclusion: Our findings demonstrated that ethanolic extract from water lily seeds could effectively reduce TMT-induced cognitive impairment and MDA levels and enhance CAT activity thereby precluding neurodegeneration in the hippocampus and cerebral cortex. Thus, water lily seed extract is a potent candidate for a natural anti-neurodegenerative supplement.

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“…Ayurveda and Siddha traditions have historically used various components of the plant to treat a variety of illnesses, including infections, skin problems, and hepatic abnormalities, and as an antidote for snake and scorpion stings. This plant’s leaves have long been utilized for their anti-inflammatory, gastroprotective, and hepatoprotective effects ( Kamyab and Eshraghian, 2013 ), anti-plasmodial, neuroprotective, and chemo-preventive properties ( Bhattacharyya and Bishayee, 2013 ; Rajendran et al, 2014 ; Mataram et al, 2021 ). The plant is also effective against human pancreatic cancer, stress-induced anxiety, stress-induced oxidative and central monoaminergic changes, typhoid fever, and cerebral ischemia/reperfusion ( Ahmad et al, 2012a ; Ahmad et al, 2012b ; Mandal et al, 2012 ; Shimizu et al, 2013 ; Singh et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (Ocimum sanctum Linn) against galactosamine-induced hepatotoxicity in rats

Kamel,

Karim,

Bafail

et al. 2023

Front. Pharmacol.

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Ocimum sanctum L. (Tulsi; Family: libiaceae), also known as “The Queen of herbs” or “Holy Basil,” is an omnipresent, multipurpose plant that has been used in folk medicine of many countries as a remedy against several pathological conditions, including anticancer, antidiabetic, cardio-protective, antispasmodic, diaphoretic, and adaptogenic actions. This study aims to assess O. sanctum L.’s hepatoprotective potential against galactosamine-induced toxicity, as well as investigate bioactive compounds in each extract and identify serum metabolites. The extraction of O. sanctum L as per Ayurveda was simultaneously standardized and quantified for biochemical markers: rutin, ellagic acid, kaempferol, caffeic acid, quercetin, and epicatechin by HPTLC. Hepatotoxicity was induced albino adult rats by intra-peritoneal injection of galactosamine (400 mg/kg). The quantified hydroalcoholic and alcoholic extract of O. sanctum L (100 and 200 mg/kg body weight/day) were compared for evaluation of hepatoprotective potential, which were assessed in terms of reduction in histological damage, change in serum enzymes such as AST, ALT, ALP and increase TBARS. Twenty chemical constituents of serum metabolites of O. sanctum were identified and characterized based on matching recorded mass spectra by GC-MS with those obtained from the library-Wiley/NIST. We evaluated the hepatoprotective activity of various fractions of hydroalcoholic extracts based on the polarity and investigated the activity at each phase (hexane, chloroform, and ethyl acetate) in vitro to determine how they affected the toxicity of CCL4 (40 mM) toward Chang liver cells. The ethyl acetate fraction of the selected plants had a higher hepatoprotective activity than the other fractions, so it was used in vacuum liquid chromatography (VLC). The ethyl acetate fraction contains high amounts of rutin (0.34% w/w), ellagic acid (2.32% w/w), kaempferol (0.017% w/w), caffeic acid (0.005% w/w), quercetin (0.038% w/w), and epicatechin (0.057% w/w) which are responsible for hepatoprotection. In comparison to standard silymarin, isolated bioactive molecules displayed the most significant hepatoprotective activity in Chang liver cells treated to CCl4 toxicity. The significant high hepatoprotection provided by standard silymarin ranged from 77.6% at 100 μg/ml to 83.95% at 200 μg/ml, purified ellagic acid ranged from 70% at 100 μg/ml to 81.33% at 200 μg/ml, purified rutin ranged from 63.4% at 100 μg/ml to 76.34% at 200 μg/ml purified quercetin ranged from 54.33% at 100 μg/ml to 60.64% at 200 μg/ml, purified epicatechin ranged from 53.22% at 100 μg/ml to 65.6% at 200 μg/ml, and purified kaempferol ranged from 52.17% at 100 μg/ml to 60.34% at 200 μg/ml. These findings suggest that the bioactive compounds in O. sanctum L. have significant protective effects against galactosamine-induced hepatotoxicity.

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The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory on the rat model of Alzheimer’s disease

Cited by 16 publications

References 39 publications

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment

Kolaviron neuroprotective effect against okadaic acid-provoked cognitive impairment

Neuroprotective effect of water lily (Nymphaea pubescens Willd) seed ethanolic extract against trimethyltin-induced cognitive impairment and neurodegeneration in mice

Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (Ocimum sanctum Linn) against galactosamine-induced hepatotoxicity in rats

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