The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice

Gong, Xiaokang; Ru, Qin; Xiong, Qi; Chen, Lin; Si, Yuanren; Xiao, Haipeng; Li, Chaoying

doi:10.1007/s12640-019-00069-z

Cited by 11 publications

(5 citation statements)

References 62 publications

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“… 74 Decreased Bcl-2 expression level and increased cleaved caspase-3 expression level in PFC as well as increased hyperpolarization-activated cyclic-nucleotide-gated non-selective cation 1 (HCN1) channel, as the key regulators of memory function in the hippocampus are other mechanisms involved in NOR impairment induced by MA. 40 …”

Section: Discussionmentioning

confidence: 99%

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

Seyedhosseini Tamijani,

Beirami,

Ghazvini

et al. 2023

Addict Health

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Background: Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be responsible for MA-induced NOR alterations. Methods: A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the past 10 years. Findings: The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of monoaminergic systems. Conclusion: NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new therapeutic agents in MA-addicted individuals.

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Section: Discussionmentioning

confidence: 99%

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

Seyedhosseini Tamijani,

Beirami,

Ghazvini

et al. 2023

Addict Health

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“…There are five types of dopamine receptors grouped into two major subclasses: DRD1-like, including DRD1 and D1RD5, and DRD2-like, including DRD2, DRD3, and DRD4, which often interact to regulate neurotransmission . Repeated METH exposure could increase the protein expression of DRD2 in the hippocampus area and reduce the protein expression of DAT (Zhou et al, 2019), and pretreatment with DRD2 antagonist sulpiride attenuated the effects of METH on egocentric and spatial learning and memory (Gutierrez et al, 2019). DAT-KO rats demonstrated deficits in sensorimotor gating and working memory tests (Leo et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway

Xiang

Xiong

et al. 2021

Front. Pharmacol.

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Methamphetamine (METH) abuse exerts severe harmful effects in multiple organs, especially the brain, and can induce cognitive dysfunction and memory deficits in humans. Krill oil is rich in polyunsaturated fatty acids, while its effect on METH-induced cognitive impairment and mental disorders, and the underlying mechanism remain unknown. The aim of the present study was to investigate the protective effect of krill oil on METH-induced memory deficits and to explore the molecular mechanisms by using an integrated strategy of bioinformatics analysis and experimental verification. METH-exposed mice were treated with or without krill oil. Learning and memory functions were evaluated by the Morris water maze. The drug–component–target network was constructed in combination with network pharmacology. The predicted hub genes and pathways were validated by the Western blot technique. With krill oil treatment, memory impairment induced by METH was significantly improved. 210 predicted targets constituted the drug–compound–target network by network pharmacology analysis. 20 hub genes such as DRD2, MAPK3, CREB, BDNF, and caspase-3 were filtered out as the underlying mechanisms of krill oil on improving memory deficits induced by METH. The KEGG pathway and GO enrichment analyses showed that the MAPK signaling pathway, cAMP signaling pathway, and dopaminergic synapse pathway were involved in the neuroprotective effects of krill oil. In the hippocampus, DRD2, cleaved caspase-3, and γ-H2AX expression levels were significantly increased in the METH group but decreased in the krill oil–treated group. Meanwhile, krill oil enhanced the expressions of p-PKA, p-ERK1/2, and p-CREB. Our findings suggested that krill oil improved METH-induced memory deficits, and this effect may occur via the MAPK signaling pathway and dopaminergic synapse pathways. The combination of network pharmacology approaches with experimental validation may offer a useful tool to characterize the molecular mechanism of multicomponent complexes.

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“…A recent study proved that l -SPD alleviates memory deficits in Alzheimer’s disease rats by affecting dopaminergic pathways and synaptic plasticity ( Hao et al, 2015 ). Our previous study also demonstrated that l -SPD pre-treatment rescues METH-induced memory deficits by suppressing upregulated HCN1 channels and the dopaminergic pathway ( Zhou et al, 2019 ).…”

Section: Introductionmentioning

confidence: 90%

The Role of Chinese Herbal Therapy in Methamphetamine Abuse and its Induced Psychiatric Symptoms

Chen

Xiong

et al. 2021

Front. Pharmacol.

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Repeated intake of methamphetamine (METH) leads to drug addiction, the inability to control intake, and strong drug cravings. It is also likely to cause psychiatric impairments, such as cognitive impairment, depression, and anxiety. Because the specific neurobiological mechanisms involved are complex and have not been fully and systematically elucidated, there is no established pharmacotherapy for METH abuse. Studies have found that a variety of Chinese herbal medicines have significant therapeutic effects on neuropsychiatric symptoms and have the advantage of multitarget comprehensive treatment. We conducted a systematic review, from neurobiological mechanisms to candidate Chinese herbal medicines, hoping to provide new perspectives and ideas for the prevention and treatment of METH abuse.

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The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice

Cited by 11 publications

References 62 publications

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

Krill Oil Alleviated Methamphetamine-Induced Memory Impairment via the MAPK Signaling Pathway and Dopaminergic Synapse Pathway

The Role of Chinese Herbal Therapy in Methamphetamine Abuse and its Induced Psychiatric Symptoms

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