The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors

Yang, Le; Li, Xubo; Yang, Qi; Zhang, Kun; Zhang, Nan; Guo, Yanyan; Feng, Bin; Zhao, Ming; Wu, Yumei

doi:10.1016/j.tiv.2013.01.001

Cited by 32 publications

(29 citation statements)

References 31 publications

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“…Phytochemical and pharmacological studies showed that angular-type pyranocoumarins are the major constituents of this plant [3][4][5][6][7][8][9], and these compounds have various beneficial effects such as anti-inflammatory [10][11][12], antiasthma [13], chemopreventive [14], smooth muscle relaxant [15], neuroprotective [16], and anti-osteoclastogenic properties [17].…”

Section: Introductionmentioning

confidence: 99%

“…As a part of the ongoing projects for the discovery of new anticancer drugs from traditional herbal medicines, chromatographic separation of a 70% ethanol (EtOH) extract of the roots of P. praeruptorum led to the isolation of a new angular-type pyranocoumarin (1), along with 15 compounds: 12 pyranocoumarins (2-13), two furanocoumarins (14,15), and a polyacetylene (16). The structures of the isolates were determined spectroscopically using one-dimensional (1D)-and two-dimensional (2D)-nuclear magnetic resonance (NMR) analysis.…”

Section: Introductionmentioning

confidence: 99%

“…The structures of the isolates were determined spectroscopically using one-dimensional (1D)-and two-dimensional (2D)-nuclear magnetic resonance (NMR) analysis. All the compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) were evaluated for multidrug resistance (MDR) reversal and anti-inflammatory activity against multidrug resistant MES-SA/Dx5 cancer and lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Here, we 1 Hz, H-4′′′), 1.81 (3H, m, H-5′′′)] were observed from the 1 H-NMR spectrum.…”

Section: Introductionmentioning

confidence: 99%

“…The 15 known compounds were identified as (+)-praeruptorin A (2) [20,21], (+)-praeruptorin B (3) [20,21], (+)-praeruptorin E (4) [20][21][22], selinidin (5) [23], cis-3′,4′-diisovalerylkhellactone (6) [19,24], pteryxin (7) [6], suksdorfin (8) [25,26], Pd-Ib (9) [27,28], qianhucoumarin D (10) [20,21], (+)-samidin (11) [25,[29][30][31], laserpitin (12) [32], (9R,10R)-9-acetoxy-8,8-dimethyl-9,10-dihydro-2H,8H-benzo [1,2-b:3,4-b′]dipyran-2-one-10-yl-ester (13) [33], bergapten (14) [34,35], xanthotoxin (15) [36], and falcalindiol (16) [37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

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Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

Lee

Kim

et al. 2015

Molecules

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Abstract:In the search for novel herbal-based anticancer agents, we isolated a new angular-type pyranocoumarin, (+)-cis-(3 1 S,4 1 S)-3 1 -angeloyl-4 1 -tigloylkhellactone (1) along with 12 pyranocoumarins (2-13), two furanocoumarins (14, 15), and a polyacetylene (16) were isolated from the roots of Peucedanum praeruptorum using chromatographic separation methods. The structures of the compounds were determined using spectroscopic analysis with nuclear magnetic resonance (NMR) and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). The multidrug-resistance (MDR) reversal and anti-inflammatory effects of all the isolated compounds were evaluated in human sarcoma MES-SA/Dx5 and lipopolysaccharide (LPS)-induced RAW 264.7 cells. Among the 16 tested compounds, two (2 and 16) downregulated nitric oxide (NO) production and five (1, 7, 8, 11, and 13) inhibited the efflux of drugs by MDR protein, indicating the reversal of MDR. Therefore, these compounds may be potential candidates for the development of effective agents against MDR forms of cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

Lee

Kim

et al. 2015

Molecules

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“…Neuronal cell viability was determined by MTT assay as previously described [21] with some modifications. Briefly, neurons were used on day 7 (DIV 7).…”

Section: Cell Viability Analysismentioning

confidence: 99%

Neuroprotection of Sesamin against Cerebral Ischemia In-Vivo and N-Methyl-D-Aspartate-Induced Apoptosis In-Vitro

Tian¹,

Tian²

2015

Biochem Pharmacol (Los Angel)

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Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

Zhu

Jiang

2018

Molecular Nutrition Food Res

126

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Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities, including antitumor, anti-inflammation, antiviral, and antibacterial effects. In this paper, the current development of coumarin-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literature published in the past 20 years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring has remarkable antioxidant and antitumor activities. Coumarins with aryl groups at the C-4 position have good activities in anti-HIV, antitumor, anti-inflammation, and analgesia. C-3 phenylcoumarins have strong anti-HIV and antioxidant effects. Tetracycline pyranocoumarins can significantly inhibit HIV; osthol structural analogues have antimicrobial activity. Praeruptorin C and its derivatives play an important role in lowering blood pressure and dilating coronary arteries, and khellactone derivatives have significant inhibitory effects on AIDS, cancer, and cardiovascular diseases. It is concluded that the specific site on the core structure of coumarin exhibits one or more activities due to the electronic or steric effects of the substituents. This review is intended to be conducive to rational design and development of more active and less toxic agents with a coumarin scaffold.

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The neuroprotective effect of praeruptorin C against NMDA-induced apoptosis through down-regulating of GluN2B-containing NMDA receptors

Cited by 32 publications

References 31 publications

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

Neuroprotection of Sesamin against Cerebral Ischemia In-Vivo and N-Methyl-D-Aspartate-Induced Apoptosis In-Vitro

Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure–Activity Relationships

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