The Neuroprotective Effect of Thiopental on the Postoperative Neurological Complications in Patients Undergoing Surgical Clipping of Unruptured Intracranial Aneurysm: A Retrospective Analysis

Kim, Byung Gun; Jeon, Young Tae; Han, Jiwon; Bae, Yu Kyung; Lee, Si Un; Ryu, Jin Suk; Koo, Chang Hoon

doi:10.3390/jcm10061197

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Induction of the general anesthesia related to the endovascular stroke condition has been reported in the area of anesthetic component application for controlling the neuroprotective functions of the drug components. Thiopental is related to the area of the lower rate of the neuroprotective functionality among the rat brain [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Thiopental on Ischemic Stroke in Rat Brain in Spontaneously Hypertensive Rats

You

Zhao

Yan

et al. 2022

Applied Bionics and Biomechanics

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Motivation and Problem Statement. Thiopental is an anesthetic drug related to the condition of controlling the area of neurological contexts. This study is related to the analysis of effectiveness for the condition of thiopental application on spontaneously hypertensive rats. Methodology. We have evaluated the thiopental induction as the anesthetic agent. The hypertensive rats were selected to administer thiopental in the form of anesthesia. The selection and application of hypertensive strokes are related to the derivation of an inducible model to assess the efficacy for analyzing the ischemic stroke parameters which relate to the human body. We used middle cerebral artery occlusion (MCAO) models related to spontaneous hypertension with the area of examining the complications in ischemic stroke. Results and Conclusion. The study focused on the experimental analysis based on the selection of spontaneously hypertensive rats associated with the incidence of ischemic stroke. Application of thiopental has reported the weak functionality and mechanism on the relaxation of neuronal activity in the case of rat brain. The considered population of the spontaneously hypertensive rats is evaluated based on the condition of effectiveness as well as the duration of the medication effects within the rat brain. Involvement of thiopental in the case of ischemic stroke has provided the area of risk development for high rate of death incidences after occurrence of acute ischemic stroke. A complication in the area of defining neuroprotective actions provides difficulty in drawing an appropriate conclusion of the study.

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Section: Discussionmentioning

confidence: 99%

Effect of Thiopental on Ischemic Stroke in Rat Brain in Spontaneously Hypertensive Rats

You

Zhao

Yan

et al. 2022

Applied Bionics and Biomechanics

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“…[28][29][30][31][32][33] Pharmacological burst-suppression during TC placement, a seemingly sensible maneuver to improve tolerance to focal ischemia by reducing CMRO2, is one such measure that has since been adopted into clinical practice in many institutions despite the absence of any strong clinical evidence supporting its routine use. 29,30,[34][35][36][37] While 2 studies-a post hoc analysis of the Intraoperative Hypothermia for Aneurysm Surgery Trial by Hindman et al 38 and a retrospective review with propensity score matching analysis by Kim et al 39 -explored the effects of pharmacological neuroprotection during TC placement, neither performed a logistic regression analysis with the intraoperative EEG end point as a variable of interest, and thus no inference can be drawn on whether pharmacological burst-suppression was beneficial during TC placement.…”

Section: Cerebral Protection In Cerebral Aneurysm Surgerymentioning

confidence: 99%

Electroencephalographic Burst-Suppression, Perioperative Neuroprotection, Postoperative Cognitive Function, and Mortality: A Focused Narrative Review of the Literature

Ma¹,

Bebawy

2021

Anesthesia &Amp; Analgesia

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Burst-suppression is an electroencephalographic pattern that results from a diverse array of pathophysiological causes and/or metabolic neuronal suppression secondary to the administration of anesthetic medications. The purpose of this review is to provide an overview of the physiological mechanisms that underlie the burst-suppression pattern and to present in a comprehensive way the available evidence both supporting and in opposition to the clinical use of this electroencephalographic pattern as a therapeutic measure in various perioperative settings. (Anesth Analg 2022;135:79-90) GLOSSARY ACNS = American Clinical Neurophysiology Society; ADAPT-2 = Anesthetic Depth and Postoperative Delirium Trial-2; ATP = adenosine triphosphate; [ATP] I = intracellular ATP concentration; BIS = bispectral index; BSR = burst-suppression ratio; CBF = cerebral blood flow; CEA = carotid endarterectomy; CI = confidence interval; CMRO2 = cerebral metabolic rate of oxygen consumption; CPB = cardiopulmonary bypass; CV = cardiovascular; EEG = electroencephalogram; ENGAGES = Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes; ET = end-tidal; GABA = gamma-aminobutyric acid; GOS = Glasgow Outcome Scale; HR = hazard ratio; IAR = intraoperative aneurysm rupture; ICP = intracranial pressure; ICU = intensive care unit; K ATP = ATPgated potassium channels; MAC = minimum alveolar concentration; MAP = mean arterial pressure; OR = odds ratio; PACU = postanesthetic care unit; PD = postoperative delirium; pEEG = processed EEG; POD = postoperative day; RCT = randomized controlled trial; TC = temporary clip Basic, Clinical and Systems Neuroscience

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Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

Ferdous,

Bhuia,

Chowdhury

et al. 2024

ChemistrySelect

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The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k−1g, i.p.) and diazepam (DZP) (2 mg k−1g, i.p.) were administered to the experimental animals either single or combined. TS (20 mg k−1g, i.p.) was administered to induce sleep, and latency with sleeping duration was observed for 3 h. The in silico investigation was conducted to predict the role of ABR in the gamma‐aminobutyric acid A (GABAA) receptor in the sleeping process and to evaluate pharmacokinetics and toxicity. Results showed that ABR (10 mg k−1g) significantly (p < 0.05) decreased the latency period (8.20 ± 1.85 min) and enhanced sleep duration (187.8 ± 8.87 min) in comparison with the control group. Additionally, the co‐treatments of ABR and DZP remarkably reduced the latency period (4.40 ± 0.24 min) and increased the sleeping duration (201.40 ± 5.89 min) compared to the single therapy. The molecular docking indicated that ABR has a binding affinity of −7.4 kcal/mol for the GABAA receptor. In conclusion, ABR provides strong sedative and synergistic efficacy on TS‐induced sleeping mice via the GABAergic system.

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The Neuroprotective Effect of Thiopental on the Postoperative Neurological Complications in Patients Undergoing Surgical Clipping of Unruptured Intracranial Aneurysm: A Retrospective Analysis

Cited by 6 publications

References 41 publications

Effect of Thiopental on Ischemic Stroke in Rat Brain in Spontaneously Hypertensive Rats

Effect of Thiopental on Ischemic Stroke in Rat Brain in Spontaneously Hypertensive Rats

Electroencephalographic Burst-Suppression, Perioperative Neuroprotection, Postoperative Cognitive Function, and Mortality: A Focused Narrative Review of the Literature

Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

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