The neuroprotective effect of Xylopia parviflora against aluminum chloride-induced neurotoxicity in rats

Dibacto, Ruth Edwige Kemadjou; Ambamba, Bruno Dupon Akamba; Ella, Fils Armand; Nyangono, Christine Fernande Biyegue; Nanhah, Jules Vidal Kamga; Fonkoua, Martin; Minka, Réné Samuel; Ngondi, Judith Laure

doi:10.1016/j.heliyon.2022.e09896

Cited by 6 publications

(1 citation statement)

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“…In addition, besides epidemiological studies, the articles on dementia from FS-SSA also report the therapeutic potential of various medicinal plants in vivo, in vitro, and in silico models of AD. In vivo studies were mainly in: (i) Beta-amyloid rat models of AD obtained either by injection of Aβ 1-40 in the CA1 layer of the hippocampus or by intraventricular injection of amyloid-β1-42 (Aβ 1-42 ) [152,153]; (ii) Rat, mouse, and zebra sh memory impairment models induced by intraperitoneal injection with cholinergic receptor blocker scopolamine [154][155][156]; and (iii) Rat cognitive de cits induced by chronic exposure to aluminum chloride [157] and D-galactose [158]. Models used in in vitro studies were: (i) AD-like neuroin ammatory conditions mimicked by exposure of mouse microglia cell lines to lipopolysaccharide (LPS) [159]; and (ii) Increased oxidative stress, in ammation, and cholinesterase activity in neuronal cell cultures exposed to stressors [152,160].…”

Section: Research On Dementia and Cognitive Impairment In French-spea...mentioning

confidence: 99%

Dementia and cognitive impairment in French-speaking Sub-Saharan Africa: a comprehensive review on moving out of the shadows of neglect

Nkouonlack¹,

Njamnshi²,

Angwafor³

et al. 2023

Preprint

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Dementia is a global public health problem with increasing prevalence and incidence worldwide. The African continent is expected to bear the biggest brunt of the burden of dementia by 2050 because of the rapid demographic changes, including rapid population growth, an increase in life expectancy, and ageing. However, French-speaking Sub-Saharan African (FS-SSA) countries are underrepresented in research on dementia in Africa. While the reasons are diverse and complex, linguistic and cultural barriers to research, disproportionately affect these countries and may be significant factors. Any efforts, therefore, to redress the burden of dementia in Africa must consider the specific demographic, cultural, and linguistic characteristics of FS-SSA countries. This scoping review explores the current state of knowledge in dementia and cognitive impairment in Sub-Saharan Africa, highlighting research gaps and specific patterns unique to FS-SSA Africa. We identify pathways for research to bridge the knowledge gaps on dementia in FS-SSA as part of the global endeavor to tackle dementia worldwide.

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