The neuroprotective effects of caffeine in neurodegenerative diseases

Kolahdouzan, Mahshad; Hamadeh, Mazen J.

doi:10.1111/cns.12684

Cited by 230 publications

(193 citation statements)

References 102 publications

(319 reference statements)

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“…Caffeine is thought to act as an adenosine receptor antagonist, and to reduce inflammation and lipid-mediated oxidative stress (Farooqui and Farooqui, 2011; Kolahdouzan and Hamadeh, 2017). …”

Section: Other Nutritional/environmental Factors and Dna Methylationmentioning

confidence: 99%

Implications of DNA Methylation in Parkinson’s Disease

Miranda-Morales

Meier

Sandoval-Carrillo

et al. 2017

Front. Mol. Neurosci.

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It has been 200 years since Parkinson’s disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation may be altered in response to some of these factors; therefore, it is proposed that epigenetic mechanisms, particularly DNA methylation, can have a fundamental role in gene–environment interactions that are related with PD. Epigenetic changes in PD-associated genes are now widely studied in different populations, to discover the mechanisms that contribute to disease development and identify novel biomarkers for early diagnosis and future pharmacological treatment. While initial studies sought to find associations between promoter DNA methylation and the regulation of associated genes in PD brain tissue, more recent studies have described concordant DNA methylation patterns between blood and brain tissue DNA. These data justify the use of peripheral blood samples instead of brain tissue for epigenetic studies. Here, we summarize the current data about DNA methylation changes in PD and discuss the potential of DNA methylation as a potential biomarker for PD. Additionally, we discuss environmental and nutritional factors that have been implicated in DNA methylation. Although the search for significant DNA methylation changes and gene expression analyses of PD-associated genes have yielded inconsistent and contradictory results, epigenetic modifications remain under investigation for their potential to reveal the link between environmental risk factors and the development of PD.

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Section: Other Nutritional/environmental Factors and Dna Methylationmentioning

confidence: 99%

Implications of DNA Methylation in Parkinson’s Disease

Miranda-Morales

Meier

Sandoval-Carrillo

et al. 2017

Front. Mol. Neurosci.

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“…Many reports show beneficial association coffee drinking with human health. For instance it prevent symptomatic gallstone disease in women [60], lower 23-50% risk of type II Diabetes, which is a various health disturbance, recently affiliate about approximately 300 million people in the globe [32,61], 20% lower risk of death in men and 26% death of women, Alzheimer 's disease, and Dementia that mainly occur in peoples whose ages are 65 and more [62][63][64]. Some of the health benefits are described in Table 3 below.…”

Section: Health Benefit and Risk Of Coffee Consumptionmentioning

confidence: 99%

“…The neurodegenerative disease most common in old people over 65 years of age and above [64,89,[91][92][93] [32, 61,[94][95][96][97][98][99][100][101] Coffee consumption can lower about 26% probability of colorectal cancer, especially distal colon cancer. It is known as a healthy beverage for the prevention of colorectal cancer.…”

Section: Health Benefit Of Coffee Consumption Description Of Action Smentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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Coffee is the world's beloved drink that is the most regularly consumed caffeine-containing beverage next to water and tea. It contains a multipart combination of chemicals constituents, which associated with health benefits, most consumers, begin their day with a minimum a cup of coffee after eating food, and end their workday with coffee. It is considered as a significant part of modern daily life because it has an alerting outcome on the human brain. Opposing this, various groups report experiencing uneven health risks thus hesitant to drink coffee, this suggests individual disparity to coffee intolerance. The aim of this review was to in brief summarize health benefits and risks coffee consumption. Most of the informative reports suggested that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among these it is used to boosts our physical performance, burn fat, reduces risk of stroke, liver, prostate and colorectal cancer by 20%, risk of Parkinson's disease by 25%, lower risk of Type II diabetes, reduces risk of dementia and protects our mind, brightens our mood, helps us to fight depression and minimize risk of suicide by 50%. In addition, coffee consumers have less risk of heart disease, with strongly integrated DNA. Also reports that coffee drinking has also naturally extended sleep latency, minimizes total sleep time and its effectiveness, and worsened supposed sleep feature.However, from positive health prospect of coffee consumption, a recent study finds coffee consumption does not always provide protective benefits because overdrinking is associated with negative impact or risk on our health. Some negative impact of coffee consumption on our health; it reduces appetite levels for food, impact on pregnant women, on people with cholesterol, cause insomnia and restlessness, breast tissue cysts in women, incontinence digestive disorders, and risk of headaches. In addition, decrease fertility probability in female and male, cause allergies and miscarriage, forceful heart contractions, anxiety, depression and the need for anxiety medication, inhibits collagen production in the skin of human being, less hearing loss improvement, does not help with extended sleep deprivation interferes with ossification and could also lead to greater risk of bone fracture. Finally, the most recent studies reported that coffee consumption is beneficial for our health when it is optimum range approximately four cups on average. The supplementary research will be crucial to make clear that both the health benefits and risk of coffee consumption.

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“…In recent years, evidence of health benefits associated with consumption of caffeine and other methylxanthines has been accumulating (Monteiro, Alves, Oliveira, & Silva, 2016, Furman et al, 2017, Franco, Oñatibia-Astibia, & Martínez-Pinilla, 2013. These benefits range from lowering of inflammation to the prevention of neurodegenerative disease (Chrysant, 2017;Kolahdouzan & Hamadeh, 2017). The effects of methylxanthines are primarily thought to be due to their binding to adenosine receptors (Monteiro et al, 2016, Salomone, Galvano, & Li, 2017.…”

Section: Introductionmentioning

confidence: 99%

Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase

Shanahan¹,

O'Sullivan

Tipton

et al. 2018

J Food Biochem

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Methylxanthines are among the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years. Primary Amine Oxidase (PrAO) has been recognized as a therapeutic target for the amelioration of inflammatory, vascular, and neurodegenerative diseases. Previous work in our laboratories showed that caffeine inhibited Bovine PrAO with a Ki of 1.0 mM using benzylamine as substrate. This study aimed to extend our previous work and explore the possibility that related methylxanthines might influence PrAO activity. While paraxanthine, theophylline, and 7‐methylxanthine had little effect on PrAO, theobromine was a noncompetitive inhibitor with a Ki of 276 ± 44 µM. The specific structural elements of methylxanthines that are required for inhibition allow us to suggest that their binding site on PrAO may be a target for therapeutics. The health benefits associated with dietary methylxanthine consumption could involve PrAO inhibition. Practical applications Inhibition of PrAO by methylxanthines may be significant in conferring health benefits. The design of PrAO inhibitors based on the structural motifs identified in this study (N‐methylation at specific locations) is indicated. Existing therapeutics based on a core xanthine structure can be evaluated for their effects on PrAO. PrAO inhibition must be considered as a potential mediator of the beneficial health effects of some methylxanthines. If inhibition in human tissues is comparable to, or greater than, that found in these studies it points to an important role for these compounds in human health.

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The neuroprotective effects of caffeine in neurodegenerative diseases

Cited by 230 publications

References 102 publications

Implications of DNA Methylation in Parkinson’s Disease

Implications of DNA Methylation in Parkinson’s Disease

Review on Health Benefit and Risk of Coffee Consumption

Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase

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