2024
DOI: 10.3389/fphar.2023.1330098
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The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Gulam Mustafa Hasan,
Saleha Anwar,
Anas Shamsi
et al.

Abstract: Traumatic brain injury (TBI) leads to brain damage, comprising both immediate primary damage and a subsequent cascade of secondary injury mechanisms. The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins. TBI disrupts molecular signaling, cell structures… Show more

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Cited by 4 publications
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“…Typically, these diseases result in a slow deterioration of cognitive abilities, motor functions, and other neurological processes [ 1 ]. Various factors contribute to the onset of these conditions, encompassing genetic susceptibility, the accumulation of misfolded proteins, neuroinflammation, and oxidative damages [ 2 , 3 ]. In spite of progress in therapeutics and target identification, “Alzheimer's disease” (AD) remains a prevalent disorder marked by neurons degeneration [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…Typically, these diseases result in a slow deterioration of cognitive abilities, motor functions, and other neurological processes [ 1 ]. Various factors contribute to the onset of these conditions, encompassing genetic susceptibility, the accumulation of misfolded proteins, neuroinflammation, and oxidative damages [ 2 , 3 ]. In spite of progress in therapeutics and target identification, “Alzheimer's disease” (AD) remains a prevalent disorder marked by neurons degeneration [ 4 ].…”
Section: Introductionmentioning
confidence: 99%