The Neuropsychology of Autobiographical Memory

Greenberg, Daniel; Rubin, David C.

doi:10.1016/s0010-9452(08)70860-8

Cited by 254 publications

(172 citation statements)

References 254 publications

(118 reference statements)

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“…is better able to retrieve memories from after his illness, though his anterograde memory is clearly not normal. This finding is also consistent with similar cases, all of whom showed moderate AA (Brown and Chobor, 1995;Hunkin et al, 1995;O'Connor et al, 1992;Ogden, 1993; for further discussion of these cases, see Conway & Fthenaki, 2000;Greenberg and Rubin, 2003;Wheeler and McMillan, 2001). While we cannot fully explain the relative preservation of M.S.…”

Section: Discussionsupporting

confidence: 89%

Visual memory loss and autobiographical amnesia: a case study

et al. 2005

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Amnesia typically results from trauma to the medial temporal regions that coordinate activation among the disparate areas of cortex that represent the information that make up autobiographical memories. We proposed that amnesia should also result from damage to these regions, particularly regions that subserve long-term visual memory [Rubin, D. C., & Greenberg, D. L. (1998). Visual memory-deficit amnesia: A distinct amnesic presentation and etiology. Proceedings of the National Academy of Sciences of the USA, 95, 5413-5416]. We previously found 11 such cases in the literature, and all 11 had amnesia. We now present a detailed investigation of one of these patients. M.S. suffers from long-term visual memory loss along with some semantic deficits; he also manifests a severe retrograde amnesia and moderate anterograde amnesia. The presentation of his amnesia differs from that of the typical medial-temporal or lateral-temporal amnesic; we suggest that his visual deficits may be contributing to his autobiographical amnesia.

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Section: Discussionsupporting

confidence: 89%

Visual memory loss and autobiographical amnesia: a case study

et al. 2005

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“…The posterior cingulate, the adjacent precuneus, and the bilateral parahippocampal gyrus showed increased activation in our patients (likely associated with visual imagery processes; Greenberg & Rubin, 2003). Regarding the bilateral parahippocampal gyrus, it also plays a pivotal role in the recruitment of the posterior brain regions (Botzung et al, 2008;Viard et al, 2011) to further generate a coherent and detailed mental simulation.…”

Section: Discussionmentioning

confidence: 60%

Neural correlates of episodic future thinking impairment in multiple sclerosis patients

Ernst

Noblet

Gounot

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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Background. Recent clinical investigations showed impaired episodic future thinking (EFT) abilities in multiple sclerosis (MS) patients. On these bases, the aim of the current study was to explore the structural and functional correlates of EFT impairment in nondepressed MS patients. Method. Twenty-one nondepressed MS patients and 20 matched healthy controls were assessed with the adapted Autobiographical Interview (AI), and patients were selected on the bases of an EFT impaired score criterion. The 41 participants underwent a functional magnetic resonance imaging (fMRI) session, distinguishing the construction and elaboration phases of the experimental EFT, and the categorical control tests. Structural images were also acquired. Results. During the EFT fMRI task, increased cerebral activations were observed in patients (relative to healthy controls) within the EFT core network. These neural changes were particularly important during the construction phase of future events and involved mostly the prefrontal region. This was accompanied by an increased neural response mostly in anterior, and also posterior, cerebral regions, in association with the amount of detail produced by patients. In parallel, structural measures corroborated a main positive association between the prefrontal regions' volume and EFT performance. However, no association between the hippocampus and EFT performance was observed in patients, at both structural and functional levels. Conclusion. We have documented significant overlaps between the structural and functional underpinnings of EFT impairment, with a main role of the prefrontal region in its clinical expression in MS patients.

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“…The posterior brain regions, and particularly those of the cortical midline and its adjacent structures (i.e., the posterior cingulate gyrus and the precuneus), are generally associated with mental visual imagery process (Greenberg and Rubin 2003;Szupnar et al 2007;Summerfield et al 2009) and contribute to the generation of details retrieved/imagined and to the subjective sense of remembering/imagining. The anterior portion of the cortical midline, including the anterior cingulate gyrus and the medial frontal gyrus, are involved in selfreferential processes (Northoff et al 2006).…”

Section: Fig 4 Significant Brain Activations For the Group X Task Inmentioning

confidence: 99%

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

Ernst

Noblet

Denkova

et al. 2015

Brain Imaging and Behavior

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Mental time travel (MTT) entails the ability to mentally travel into autobiographical memory (AM) and episodic future thinking (EFT). While AM and EFT share common phenomenological and cerebral functional properties, distinctive characteristics have been documented in healthy and clinical populations. No report, to our knowledge, has informed on the functional underpinnings of MTT impairment in multiple sclerosis (MS) patients, hence the aim of this work. We studied 22 relapsing-remitting MS patients and 22 matched controls. Participants underwent an AM/EFT assessment using the Autobiographical Interview (Levine et al. 2002), followed by a functional MRI session. The latter consisted in AM and EFT tasks, distinguishing the construction and elaboration phases of events. The results showed impaired performance for AM and EFT in patients, accompanied by increased cerebral activations mostly located in the frontal regions, which extended to the parietal, lateral temporal and posterior regions during AM/EFT tasks, relative to healthy controls. Enhanced brain activations in MS patients were particularly evident during the EFT task and involved the hippocampus, frontal, external temporal, and cingulate regions. The construction phase required greater fronto-parieto-temporal activations in MS patients relative to both healthy controls, and the elaboration phase. Taking together, our results suggested the occurrence of cerebral activation changes in the context of MTT in MS patients, expressed by distinct and common mechanisms for AM and EFT. This study may provide new insights in terms of cerebral activation changes in brain lesion and their application to clinical settings, considering AM/EFT's central role in everyday life.

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The Neuropsychology of Autobiographical Memory

Cited by 254 publications

References 254 publications

Visual memory loss and autobiographical amnesia: a case study

Visual memory loss and autobiographical amnesia: a case study

Neural correlates of episodic future thinking impairment in multiple sclerosis patients

Distinct and common cerebral activation changes during mental time travel in relapsing-remitting multiple sclerosis patients

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